Liver Status in Psychiatric Inpatients

NCT05213442 | Completed

• 1 other identifier: 2021-A02796-35
• Study Type: interventional
• Target: 450
• Locations: 1 country
• Sites: 1

Brief Summary

Adults hospitalized in psychiatry have an increased frequency of somatic disorders, in particular various liver diseases (viral hepatitis, non-alcohol related liver steatosis, alcohol related liver disease). The evaluation of these liver disorders in psychiatric inpatients remains very little explored in France, contributing to the poor overall medical status of psychiatric patients. The LIVERSPIN study aims to estimate the prevalence rates of liver pathologies in psychiatric inpatients and to explore the factors associated with the existence of a liver pathology

Conditions

Psychiatric Illness

Outcome Measures

Primary Outcomes (1)

• HCV diagnosis

  HCV diagnosis defined by positive HCV antibodies in blood

  At inclusion

Secondary Outcomes (4)

• HBV diagnosis

  At inclusion

• HIV diagnosis

  At inclusion

• Suspicion of NAFLD

  At inclusion

• Suspicion of alcoholic liver disease

  At inclusion

Study Arms (1)

All inpatients in Vinatier psychiatric Hospital

OTHER

All hospitalized patients can potentially be recruited. They will benefit from the usual clinical and paraclinical examinations as part of their hospitalization diagnostic work-up. For the determination of biological analyses, a blood sample will be taken following inclusion as well as a Fibroscan examination.

Diagnostic Test: To estimate the prevalence rates of liver disease in psychiatric inpatients and to explore factors associated with the existence of liver disease.

Interventions

To estimate the prevalence rates of liver disease in psychiatric inpatients and to explore factors associated with the existence of liver disease. DIAGNOSTIC_TEST

Patients will receive the usual clinical and paraclinical examinations as part of their hospitalization diagnostic workup. For the biological analyses, a blood sample will be taken following inclusion as well as a Fibroscan examination. Data will be collected from the patient, or if necessary from the health care team, using the medical record (interview and/or self-questionnaires).

All inpatients in Vinatier psychiatric Hospital

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Age \>18 years old
• Social insurance
• Current hospitalization in any psychiatric unit of the participating center
• Adult or legal representative who has given written and informed consent to participate in the study. By default, the oral consent of the adult will be obtained (as well as the written consent of the legal representative)
• Information given to the curator(for people under curatorship)

You may not qualify if:

• \- Clinical state of the patient which do not allow the collection of study data (according to the investigator)

Sponsors & Collaborators

• Hôpital le Vinatier: lead
• Hospices Civils de Lyon: collaborator

Study Sites (1)

Centre Hospitalier Le Vinatier

Bron, Auvergne-Rhône-Alpes, 69678 cedex, France

Location

MeSH Terms

Conditions

Mental Disorders

Study Officials

• Benjamin ROLLAND, MD, PhD

  CH LE VINATIER

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: DIAGNOSTIC
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Model Details: Monocentric, non randomized, non comparative cross-sectional study

Study Record Dates

• First Submitted: January 26, 2022
• First Posted: January 28, 2022
• Study Start: April 6, 2022
• Primary Completion: December 15, 2023
• Study Completion: December 15, 2023
• Last Updated: February 14, 2024

Record last verified: 2024-02

Data Sharing

• IPD Sharing: Will not share

Locations

FR (1)