Peripheral Choroidal Layer Response

NCT05132140 | Unknown

• 1 other identifier: STUDY00003210
• Study Type: interventional
• Target: 40
• Locations: 0 countries
• Sites: N/A

Brief Summary

The study aims to examine how the vascular layer of the eyeball (choroidal layer) responds when part of the visual field is exposed to specially generated visual stimulus. The study goal will be accomplished by producing specific blur visual stimulus at a particular visual field position and measure any consistent thickness change pattern in the choroidal layer. We propose to test the hypothesis that regional changes in the choroidal thickness may be induced differently after short-term exposure to specific visual stimuli.

Conditions

Myopia

Outcome Measures

Primary Outcomes (1)

• choroidal thickness

  A commercially available optical coherence tomography system will be used to measure changes in choroidal layer thickness before and after manipulating the peripheral optics.

  up to 60 mins

Study Arms (1)

normal healthy group

EXPERIMENTAL

Adaptive optics system: this system controls the optical quality of the eye at the peripheral visual field temporarily.

Device: adaptive optics system

Interventions

adaptive optics system DEVICE

the system consists of a wavefront sensor and a deformable mirror that measure and correct (or modify) the eye's optical imperfections (aberrations).

normal healthy group

Eligibility Criteria

• Age: 18 Years - 40 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Is between the ages of 18 and 40 yrs old
• Has normal best corrected visual acuity being 20/20 or better
• Has spherical refractive error between +1.00D and -6.00D.
• Is capable of fixating on the target.
• Has no prior ocular surgery.
• Has no ocular pathology except keratoconus.
• Can tolerate dilating eye drops

You may not qualify if:

• A person will be excluded from the study if he/she:
• Does not fall within above mentioned age group.
• Has chronic or systemic eye disease that would interfere with pupil dilation via eye drops.
• Underwent ocular surgeries or history of ocular trauma
• Has shallow anterior chamber angle and/or glaucoma.
• Has clinically significant dry eye.
• Has signs of any choroidal or retinal pathology, and abnormalities in the visual pathway
• Has spherical refractive error that exceeds the limits outlined above.
• Has binocular anomalies (e.g. convergence insufficiency, strabismus, pseudo-myopia, amblyopia).
• Is an adult unable to consent
• Is an individual who is not yet adult (infants, children, teenagers)
• Is a pregnant woman
• Is a prisoner
• Is a student for whom you have direct access to/influence on grades
• Is an economically and/or educationally disadvantaged person

Sponsors & Collaborators

• University of Houston: lead

MeSH Terms

Conditions

Myopia

Condition Hierarchy (Ancestors)

Refractive Errors; Eye Diseases

Study Officials

• Geunyoung Yoon, PhD

  University of Houston

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Geunyoung Yoon, PhD

CONTACT

7137437860; gyoon2@central.uh.edu

Dibyendu Pusti, PhD

CONTACT

5854069837; dpusti@central.uh.edu

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: November 11, 2021
• First Posted: November 24, 2021
• Study Start: November 1, 2021
• Primary Completion: November 1, 2022
• Study Completion: May 1, 2023
• Last Updated: November 30, 2021

Record last verified: 2021-11

Data Sharing

• IPD Sharing: Will not share