Study of the Prognostic Role of Gene Polymorphism in the Development of B-cell Leukemias and Lymphomas in Children of Kazakh Nationality

NCT05095155 | Completed

• 1 other identifier: 1190
• Study Type: observational
• Target: 400
• Locations: 1 country
• Sites: 1

Brief Summary

To search for a genetic marker of B-cell leukemias and lymphomas in children of Kazakh nationality, a single nucleotide polymorphism (SNP) analysis of DNA obtained from the peripheral blood of patients with B-cell leukemias and lymphomas in children of Kazakh nationality and normal control will be performed.

Conditions

B Cell Leukemia; Lymphoma

Keywords

SNP

Outcome Measures

Primary Outcomes (1)

• Associated with B-cell lymphoma and B-cell acute lymphoblastic leukemia

  Genotype frequency of SNP in the study genes of participants and control participants.

  1 year

Study Arms (2)

Experimental group:

children with B-cell leukemia and lymphoma of Kazakhstani nationality

Genetic: SNP analysis of the DNA

Control group

children without B-cell leukemia and lymphoma of Kazakhstani nationality

Genetic: SNP analysis of the DNA

Interventions

SNP analysis of the DNA GENETIC

SNP analysis of the DNA obtained from peripheral blood sample

Also known as: SNP analysis of the DNA obtained from peripheral blood sample

Control group; Experimental group:

Eligibility Criteria

• Age: 0 Years - 18 Years
• Sex: all
• Age Groups: Child (0-17), Adult (18-64)
• Sampling Method: Probability Sample

Study Population

Children of the Kazakh population

You may qualify if:

• ethnicity - Kazakhs in at least three generations
• active disease or a history of B-line ALL or B-NHL, established on the basis of morphological, cytochemical, immunophenotypic or immunohistochemical research methods with confirmation of the fact of the disease in medical documentation
• Signed voluntary informed consent of the legal representative to participate in the project

You may not qualify if:

• Children suffering from other types of malignant neoplasms
• Children with B-linear leukemia and lymphomas with concomitant specified genetic and chromosomal diseases
• Children of non-Kazakh nationality
• Absence of signed informed consent or informed refusal of the legal representative to participate in the study before starting therapy

Sponsors & Collaborators

• Asfendiyarov Kazakh National Medical University: lead

Study Sites (1)

Scientific Center of Pediatrics and Pediatric Surgery

Almaty, Kazakhstan

Location

Biospecimen

Retention: SAMPLES WITH DNA

Blood

MeSH Terms

Conditions

Leukemia, B-Cell; Lymphoma

Condition Hierarchy (Ancestors)

Leukemia, Lymphoid; Leukemia; Neoplasms by Histologic Type; Neoplasms; Hematologic Diseases; Hemic and Lymphatic Diseases; Lymphoproliferative Disorders; Lymphatic Diseases; Immunoproliferative Disorders; Immune System Diseases

Study Officials

• Riza Boranbayeva, PhD

  JSC "Scientific Center of Pediatrics and Pediatric Surgery"

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Head of the Laboratory of Experimental Medicine

Study Record Dates

• First Submitted: October 21, 2021
• First Posted: October 27, 2021
• Study Start: April 1, 2022
• Primary Completion: January 20, 2023
• Study Completion: January 20, 2023
• Last Updated: March 14, 2023

Record last verified: 2023-03

Locations

KA (1)