Investigation of Genetic Disease Marker Associated With Korean Glaucoma Patients

NCT01025024 | Completed DMC

• 2 other identifiers: CNUH81510-886A080587
• Study Type: observational
• Target: 1,224
• Locations: 1 country
• Sites: 1

Brief Summary

A single-nucleotide polymorphism (SNP) analysis of DNA obtained from peripheral blood of the glaucoma patients and the normal control will be performed to find genetic marker for primary open angle glaucoma.

Conditions

Single-nucleotide Polymorphism (SNP) for Glaucoma

Keywords

SNP; single-nucleotide polymorphism; glaucoma; primary open angle glaucoma

Outcome Measures

Primary Outcomes (1)

• genotyping for the SNP associated with primary open angle glaucoma

  one year

Secondary Outcomes (1)

• genotyping for rs7961953 and additional SNPs in TMTC2 from other linkage disequilibrium patterns

  one year

Study Arms (2)

POAG group

Elevated intraocular pressure normal open angle glaucomatous optic nerve head abnormality glaucomatous visual field defect

Genetic: SNP analysis of the DNA

Normal control

Normal intraocular pressure No optic disc abnormality No visual field defect No significant ocular and systemic disease

Genetic: SNP analysis of the DNA

Interventions

SNP analysis of the DNA GENETIC

SNP analysis of the DNA obtained from peripheral blood sample

Normal control; POAG group

Eligibility Criteria

• Age: 30 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

patients with open angle glaucoma who visited glaocoma clinic of departemtn of Ophtalmology, Chungnam National University Hospital, Daejeon, south Korea

You may qualify if:

• Clinical diagnosis of primary open angle glaucoma

You may not qualify if:

• Primary open angle glaucoma combined with congenital ocular disease
• Primary open angel glaucoma combined with other ocular disease
• Significant systemic disease other than systemic hypertension and diabetes

Sponsors & Collaborators

• Chungnam National University: lead
• Korea Healthcare Technology R&D Project: collaborator
• Korea Advanced Institute of Science and Technology: collaborator

Study Sites (1)

Chungnam National University Hospital

Daejeon, 301-721, South Korea

Location

Biospecimen

Retention: SAMPLES WITH DNA

Peripheral blood sample

MeSH Terms

Conditions

Glaucoma; Glaucoma, Open-Angle

Condition Hierarchy (Ancestors)

Ocular Hypertension; Eye Diseases

Study Officials

• Chang-sik Kim, professor

  Department of Ophthalmology, Chungnam National University Hospital

  PRINCIPAL INVESTIGATOR

• Changwon Kang, professor

  Korea Advanced Institute of Science and Technology

  STUDY CHAIR

• Kyunglan Kim

  Department of Biological Sciences, Korea Advanced Institute of Science and Technology

  STUDY DIRECTOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER

Study Record Dates

• First Submitted: December 2, 2009
• First Posted: December 3, 2009
• Study Start: January 1, 2007
• Primary Completion: October 1, 2009
• Study Completion: November 1, 2009
• Last Updated: December 3, 2009

Record last verified: 2009-12

Locations

KR (1)