The Role of Genetic Factors in the Development of Idiopathic Osteoarthritis of the Knee in the Kazakh Population

NCT05095142 | Completed

• 1 other identifier: 1191
• Study Type: observational
• Target: 500
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study is to identify genetic determinants of susceptibility to idiopathic osteoarthritis of the knee . It will assist in predicting individual risks of disease progression and would help to clarify pathophysiologic mechanisms of idiopathic osteoarthritis of the knee

Conditions

Idiopathic Osteoarthritis

Keywords

SNP

Outcome Measures

Primary Outcomes (1)

• enotyping for the SNP associated with liver cirrhosis

  Genotype frequency of SNP in the study genes of participants and control participants.

  1 year

Study Arms (2)

Experimental group:

patients with idiopathic osteoarthritis of the knee

Genetic: SNP analysis of the DNA

Control group

patients without idiopathic osteoarthritis of the knee

Genetic: SNP analysis of the DNA

Interventions

SNP analysis of the DNA GENETIC

SNP analysis of the DNA obtained from peripheral blood sample

Control group; Experimental group:

Eligibility Criteria

• Age: 18 Years - 68 Years
• Sex: all
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Persons of Kazakh nationality

You may qualify if:

• Patients with bilateral idiopathic gonarthrosis aged 18 to 65 years;
• Representatives of the Kazakh ethnic group up to the 3rd generation;
• Hereditary history of arthrosis;
• Persons who are able and willing to provide written informed consent;

You may not qualify if:

• Patients with bilateral idiopathic gonarthrosis under 18 years of age and over 65 years of age;
• Representatives of other ethnic groups;
• Representatives of the Kazakh ethnic group less than 3 generations;
• No family history of bilateral idiopathic gonarthrosis;
• Patients with an acute period of the inflammatory process (laboratory and clinical signs);
• Persons who, in the opinion of the researcher, are mentally or legally incapacitated, which prevents obtaining informed consent;
• Pregnant or lactating women;
• Tuberculosis of any localization in the active phase and in history;
• Severe and decompensated diseases of the liver and kidneys, cardiovascular system;
• Severe and decompensated course of endocrine diseases;
• Autoimmune diseases;
• Systemic diseases;
• Oncological diseases;

Sponsors & Collaborators

• Asfendiyarov Kazakh National Medical University: lead

Study Sites (1)

Scientific center of traumatology and orthopedics named after academician Batpenova ND

Almaty, Kazakhstan

Location

Biospecimen

Retention: SAMPLES WITH DNA

Blood

Study Officials

• Olzhas Bekarisov, PhD

  Scientific center of traumatology and orthopedics named after academician Batpenova ND

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Head of the Laboratory of Experimental Medicine

Study Record Dates

• First Submitted: October 21, 2021
• First Posted: October 27, 2021
• Study Start: March 30, 2022
• Primary Completion: January 20, 2023
• Study Completion: January 20, 2023
• Last Updated: March 14, 2023

Record last verified: 2023-03

Locations

KA (1)