Comparison of the Effects of Sevoflurane and Desflurane on Endothelial Glycocalyx

NCT05068336 | Completed DMC

• 1 other identifier: 514-192-32
• Study Type: observational
• Target: 50
• Locations: 1 country
• Sites: 1

Brief Summary

The glycocalyx is a dynamic and complex biochemical structure composed of proteoglycans, glycoproteins, and soluble proteins. The glycocalyx interacts with various proteins such as albumin and orosomucoid to form a thick surface layer on the vessel surface that is physiologically active. This is called the endothelial surface layer. This structure is constantly changing with the blood flowing in the vein. The glycocalyx regulates oncotic pressure and also prevents leukocyte and platelet adhesion to the endothelium. Endothelial cell dysfunction is a valuable marker of increased vascular permeability and impaired angiogenesis due to cardiovascular, thoracic, renal, and metabolic diseases.

Conditions

Endothelial Dysfunction

Outcome Measures

Primary Outcomes (1)

• glycocalyx components

  The primary aim of the study was to measure the levels of heparan sulfate and syndecan, which are markers of endothelial glycocalyx structure, after the use of desflurane or sevoflurane. High biomarker levels are associated with impaired glycocalyx structure

  the study will comlete in one month

Secondary Outcomes (1)

• haemodynamic changes

  studdy will complete in one month

Study Arms (2)

desflurane

Anesthesia maintenance of the first group will be provided with desflurane, one of the inhalation anesthetics we routinely use. Before and after the operation, blood will be taken from the patients, and the blood will be centrifuged to evaluate the heparan sulfate and syndecan levels.

Diagnostic Test: desflurane anesthesia

sevoflurane

Anesthesia maintenance of the first group will be provided with sevoflurane, one of the inhalation anesthetics we routinely use. Before and after the operation, blood will be taken from the patients, and the blood will be centrifuged to evaluate the heparan sulfate and syndecan levels.

Diagnostic Test: sevoflurane anesthesia

Interventions

desflurane anesthesia DIAGNOSTIC_TEST

Anesthesia maintenance of the first group will be provided with desflurane, one of the inhalation anesthetics we routinely use. Before and after the operation, blood will be taken from the patients, and the blood will be centrifuged to evaluate the heparan sulfate and syndecan levels.

desflurane

sevoflurane anesthesia DIAGNOSTIC_TEST

Anesthesia maintenance of the first group will be provided with sevoflurane, one of the inhalation anesthetics we routinely use. Before and after the operation, blood will be taken from the patients, and the blood will be centrifuged to evaluate the heparan sulfate and syndecan levels.

sevoflurane

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

healthy volunteers

You may qualify if:

• Be in the 18-65 age rang
• Being in the ASA 1-3 risk group
• patients receiving general anesthesia

You may not qualify if:

• refuse to participate in the study

Sponsors & Collaborators

• Kocaeli Derince Education and Research Hospital: lead

Study Sites (1)

Tahsin Şimşek

Istanbul, Kartal, 34000, Turkey (Türkiye)

Location

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: PROSPECTIVE
• Target Duration: 1 Day
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: medical doctor

Study Record Dates

• First Submitted: August 20, 2021
• First Posted: October 5, 2021
• Study Start: August 25, 2021
• Primary Completion: October 25, 2021
• Study Completion: November 4, 2021
• Last Updated: November 9, 2021

Record last verified: 2021-11

Locations

TU (1)