The Effects of Watermelon Juice Supplementation on Postprandial Vascular Endothelial Function

NCT04092439 | Completed Results

• 1 other identifier: PBRC 2019-024
• Study Type: interventional
• Target: 18
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study is to test if watermelon juice supplementation improves vascular dysfunction experience during hyperglycemia.

Conditions

Endothelial Dysfunction

Outcome Measures

Primary Outcomes (1)

• Endothelial Function

  Flow mediated dilation

  Two weeks

Secondary Outcomes (1)

• Postprandial Blood Flow

  Two weeks

Study Arms (2)

Watermelon juice

EXPERIMENTAL

The study participants consumed 500 ml of 100% watermelon juice for two weeks

Dietary Supplement: Watermelon Juice

Placebo

PLACEBO COMPARATOR

The study participants consumed a watermelon flavored, fructose matched control

Dietary Supplement: Watermelon Juice

Interventions

Watermelon Juice DIETARY_SUPPLEMENT

100% Watermelon Juice

Placebo; Watermelon juice

Eligibility Criteria

• Age: 18 Years - 40 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may not qualify if:

• years of age
• BMI between 18-29.9 kg/m2
• Willing to allow researchers to draw blood and conduct imaging (DXA) for research purposes.
• Evidence or self-reported history of type 1 or 2 diabetes mellitus
• Self-reported family history of type 2 diabetes (first degree relative with type 2 diabetes)
• Evidence or self-report history of deep vein thrombosis, pulmonary embolism, cardiovascular, peripheral vascular, cerebral vascular, pulmonary, or renal disease
• Allergy to watermelon
• Use of medication known to influence study outcomes, such as:
• Insulin
• Anti-diabetics (metformin)
• Corticosteroids
• Beta-blockers
• Anti-coagulates
• Use of supplements known to influence study outcomes, such as;
• Beta-alanine

Sponsors & Collaborators

• Pennington Biomedical Research Center: lead

Study Sites (1)

Pennington Biomedical Research Center

Baton Rouge, Louisiana, 70808, United States

Location

Related Publications (13)

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  PMID: 20425069 BACKGROUND

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  PMID: 12791603 BACKGROUND

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  PMID: 8606266 BACKGROUND

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Results Point of Contact

• Title: Tim Allerton, Ph.D.
• Organization: Pennington Biomedical Research Center

timothy.allerton@pbrc.edu

225-763-2940

Study Officials

• Timothy D Allerton, PhD

  Pennington Biomedical Research Center

  PRINCIPAL INVESTIGATOR

Publication Agreements

• PI is Sponsor Employee: No
• Restrictive Agreement: No

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, INVESTIGATOR
• Purpose: TREATMENT
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Postdoctoral Fellow

Study Record Dates

• First Submitted: September 15, 2019
• First Posted: September 17, 2019
• Study Start: September 12, 2019
• Primary Completion: March 20, 2020
• Study Completion: March 20, 2020
• Last Updated: July 30, 2024
• Results First Posted: July 30, 2024

Record last verified: 2024-07

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)