Single Bout Exercise on Learning in PD

NCT04189887 | Completed

• 1 other identifier: 20190901RINC
• Study Type: observational
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

Parkinson's disease (PD) is a neurodegenerative disorder associated with a loss of dopamine in the basal ganglia and is characterized by several cardinal motor signs. In addition to the commonly recognized motor symptoms, cognitive impairments are also often observed in people with PD. Unlike motor deficits, cognitive impairments are not always responsive to dopaminergic treatment. While medication may ameliorate some cognitive dysfunctions (e.g., executive function), it may exacerbate others (e.g., motor learning). Therefore, it is crucial for clinicians to look for treatment approaches, other than medication, to enhance cognitive function. In this proposed study, the investigators are especially interested in determining a method to enhance motor learning ability in people with PD. Motor learning deficits in people with PD have been well established through different tasks including motor adaptation task such as maintain balance on a stabilometer or motor sequence task such as performing a serial reaction time task (SRTT). Motor sequence learning is important in acquiring real-life motor skill such as tying shoes laces. Based on the past evidences, people with PD have impairments in motor sequence learning, particularly in implicit sequence learning. Since implicit motor sequence learning constitutes a critical part of everyday activities such as typing and changing clothes, establishing an approach to enhance implicit sequence learning is important. In the literature conducted with non-disable adults, one of the most effective method to enhance motor learning is aerobic exercise. Only one study, to the best of knowledge, has investigated the effect of aerobic exercise on learning to maintain balance on a stabilometer in people with PD. To date, no study has investigated whether a single bout of aerobic exercise could improve implicit sequence learning in PD. Therefore, the goal of this proposed study is to investigate the effect of a single bout of aerobic exercise on implicit sequence learning and the associated neurophysiological changes in people with PD.

Conditions

Parkinson Disease

Outcome Measures

Primary Outcomes (1)

• Performance of the sequence learning task

  A serial reaction time task (SRTT) will be used to determine the sequence learning ability. At the beginning of the SRTT, only one circle will be filled with color while others remain hollow. Once the participants hit the correct button, the next target will appear. Unknown to the participants, an 12-element sequence is embedded within the random sequences. The response time of the key presses of the embedded sequence will be recorded. The change score will be calculated between the 1st and 2nd sessions, and between the 1st and 7th sessions.

  30 minutes

Secondary Outcomes (1)

• Corticomotor excitability

  50 minutes

Other Outcomes (5)

• Montreal Cognitive Assessment

  10 minutes

• Stroop test

  5 minutes

• The Trail Making test

  5 minutes

Study Arms (4)

PD+AEX

The group of people with PD which will perform aerobic exercise after motor skill acquisition

Behavioral: aerobic exercise (cycling); Behavioral: Implicit sequence learning

PD-AEX

The group of people with PD which will not perform aerobic exercise after motor skill acquisition

Behavioral: Implicit sequence learning

CON+AEX

The group of control participants which will perform aerobic exercise after motor skill acquisition

Behavioral: aerobic exercise (cycling); Behavioral: Implicit sequence learning

CON-AEX

The group of control participants which will not perform aerobic exercise after motor skill acquisition

Behavioral: Implicit sequence learning

Interventions

aerobic exercise (cycling) BEHAVIORAL

People who perform aerobic exercise will ride on a stationary bike for 20 minutes after motor skill learning

CON+AEX; PD+AEX

Implicit sequence learning BEHAVIORAL

All participants will practice the serial reaction time task (SRTT) on the first day, and retention performance will be assessed immediately, on the 2nd day, and on the 7th day of study.

Also known as: serial reaction time task (SRTT)

CON+AEX; CON-AEX; PD+AEX; PD-AEX

Eligibility Criteria

• Age: 20 Years - 90 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Participants diagnosed of idiopathic PD and non-disabled age-matched controls will be recruited.

You may qualify if:

• \) able to follow instructions to perform the tasks
• \) without other neurological disorders in addition to PD
• \) no surgery or injury of the upper extremities in recent 6 months

You may not qualify if:

• \) deep brain stimulation or pacemaker implanted
• \) a self-history of seizure
• \) unstable medical conditions
• \) a blood-relative with a history of epilepsy

Sponsors & Collaborators

• National Taiwan University Hospital: lead

Study Sites (1)

National Taiwan University Hospital

Taipei, Zhongcheng, 100, Taiwan

Location

Related Publications (1)

• Chan ST, Tai CH, Wang LY, Luh JJ, Lee YY. Influences of Aerobic Exercise on Motor Sequence Learning and Corticomotor Excitability in People With Parkinson's Disease. Neurorehabil Neural Repair. 2023 Jan;37(1):37-45. doi: 10.1177/15459683221147006. Epub 2023 Jan 12.

  PMID: 36636767 DERIVED

MeSH Terms

Conditions

Parkinson Disease

Interventions

Exercise

Condition Hierarchy (Ancestors)

Parkinsonian Disorders; Basal Ganglia Diseases; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Movement Disorders; Synucleinopathies; Neurodegenerative Diseases

Intervention Hierarchy (Ancestors)

Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Officials

• Ya-Yun Lee

  National Taiwan University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: CROSS SECTIONAL
• Target Duration: 7 Days
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: November 27, 2019
• First Posted: December 6, 2019
• Study Start: November 27, 2019
• Primary Completion: September 26, 2020
• Study Completion: December 31, 2022
• Last Updated: March 28, 2023

Record last verified: 2022-07

Data Sharing

• IPD Sharing: Will not share

Locations

TW (1)