Risk Factors and Prognosis of Adverse Cardiovascular and Kidney Events After Coronary Intervention II

NCT05050877 | Completed DMC

• 1 other identifier: 2019-555H-2
• Study Type: observational
• Target: 184,855
• Locations: 1 country
• Sites: 1

Brief Summary

As a multi-center, retrospective observation study in southern China, this study included the main study population of patients who underwent coronary angiography at 5 hospitals from Guangzhou, Shenzhen, Yangjiang, Maoming and Longyan from January 2000 to Decemeber 2020. The hospitalization information was collected in the form of direct derivation of the case, and cardiac and renal adverse events were collected through outpatient system. Data on all-cause death were obtained from the Guangdong Provincial Public Security and matched to the electronic Clinical Management System of the Guangdong Provincial People's Hospital records.

Conditions

Cardio-Renal Syndrome; Coronary Angiography; Coronary Artery Disease; Kidney Diseases; Metabolic Syndrome

Keywords

contrast-induced acute kidney injury; contrast medium; creatinine clearance; coronary angiography; chronic kidney disease; Adverse Cardiovascular and Kidney Events

Outcome Measures

Primary Outcomes (1)

• Contrast-Induced Acute Kidney Injury (CI-AKI 0.3)

  defined as a ≥ 0.3 mg/dL absolute increase in serum creatinine from baseline during the first 48 hours after the procedure

  48 hours

Secondary Outcomes (2)

• Cystatin C based CI-AKI (CI-AKI cyc)

  24-48 hours

• The change of eGFR, calculate based on CrCl and serum cystatin C

  48-72 hours

Other Outcomes (4)

• Contrast-induced Persistent kidney injury (CI-PKI)

  3 months

• Incidence of major adverse cardiovascular events

  3-12months

• Follow-up major adverse cardiovascular and clinical events

  3-12months

Study Arms (1)

coronary angiography

The investigators recruit all consecutive patients who were undergoing coronary angiography or percutaneous coronary intervention.

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

The investigators reviewed all consecutive patients who were undergoing coronary angiography.

You may qualify if:

• \. Patients referred to CAG or PCI;

Sponsors & Collaborators

• Guangdong Provincial People's Hospital: lead
• First Affiliated Hospital of Fujian Medical University: collaborator
• Maoming Hospital Affiliated to Southern Medical University: collaborator
• Shenzhen People's Hospital: collaborator
• Yangjiang People's Hospital: collaborator

Study Sites (1)

Guangdong Provincial People's Hospital

Guangzhou, Guangdong, 510080, China

Location

Related Publications (9)

• Deng L, Chen H, Xu Q, Han K, Liu J, Chen S, Deng J, Tian L, Li Z, Lu X, Liu Y, Liang Y. The High-Sensitivity C-Reactive Protein to High-Density Lipoprotein Cholesterol Ratio and the Risk of Contrast-Induced Acute Kidney Injury in Patients Undergoing Percutaneous Coronary Intervention. Rev Cardiovasc Med. 2024 Sep 23;25(9):338. doi: 10.31083/j.rcm2509338. eCollection 2024 Sep.

  PMID: 39355575 DERIVED

• Zhou Z, Qiao L, Ling Y, He Y, Chang T, Lu H, Yu S, Liu J, Guo W, Chen S, Liu Y, Chen J. Intermediate Hyperglycemia Increases the Risk of All-Cause Mortality in Premature Coronary Artery Disease Patients Undergoing Percutaneous Coronary Intervention. Rev Cardiovasc Med. 2023 Dec 13;24(12):352. doi: 10.31083/j.rcm2412352. eCollection 2023 Dec.

  PMID: 39077077 DERIVED

• Xie Y, Xu X, Wang D, Zhou Y, Kang Y, Lai W, Lu H, Liu J, Chen S, Xu J, Yan X, Huang X, Liu Y. Fibrinogen-to-Albumin Ratio and Long-Term Mortality in Coronary Artery Disease Patients with Different Glucose Metabolism Status. Rev Cardiovasc Med. 2023 Nov 16;24(11):317. doi: 10.31083/j.rcm2411317. eCollection 2023 Nov.

  PMID: 39076427 DERIVED

• Wu W, Jia C, Xu X, He Y, Xie Y, Zhou Y, Lu H, Liu J, Chen J, Liu Y. Impact of Platelet-to-HDL-Cholesterol Ratio on Long-Term Mortality in Coronary Artery Disease Patients with or Without Type 2 Diabetes: Insights from a Chinese Multicenter Cohort. J Inflamm Res. 2024 May 6;17:2731-2744. doi: 10.2147/JIR.S458950. eCollection 2024.

  PMID: 38737110 DERIVED

• Jia C, Wu W, Lu H, Liu J, Chen S, Liang G, Zhou Y, Yu S, Qiao L, Chen J, Tan N, Liu Y, Chen J. Fibrinogen to HDL-Cholesterol ratio as a predictor of mortality risk in patients with acute myocardial infarction. Lipids Health Dis. 2024 Mar 25;23(1):86. doi: 10.1186/s12944-024-02071-7.

  PMID: 38528580 DERIVED

• Lu J, He Y, Yang Y, Zhong X, Chen S, Wu B, Pan Y, Wang Y, Xiu J, Kang Y, Liu J, Liu Y, Chen S, Chen K, Chen L. Age-Related Effect of Uric Acid on Contrast-Induced Acute Kidney Injury of Patients Undergoing Coronary Angiography. Clin Interv Aging. 2023 Dec 7;18:2053-2061. doi: 10.2147/CIA.S419370. eCollection 2023.

  PMID: 38088947 DERIVED

• Liu J, Chen S, Zhou Y, Huang H, Li Q, Liang Y, Dong S, Huang X, Chen L, Zheng X, Meng R, Jia C, Chen J, Tan N, Liu Y. Proportion and number of incident cancer deaths in coronary artery disease. Cancer Med. 2023 Oct;12(19):20140-20149. doi: 10.1002/cam4.6595. Epub 2023 Sep 27.

  PMID: 37754571 DERIVED

• Liu J, Chen S, Zhou Y, Zheng X, Meng R, Tan N, Liu Y. Effect of cumulative radiation exposure from Coronary catheterization on lung cancer mortality. BMC Cancer. 2023 Aug 15;23(1):757. doi: 10.1186/s12885-023-11231-4.

  PMID: 37582730 DERIVED

• Gao F, Huang Z, Liang J, Kang Y, Ling Y, He Y, Chen J, Hong D, Zhang Z, Xu S, Wang A, Yan X, Liu J, Liu Y, Chen S, Chen J. Association of malnutrition with all-cause and cardiovascular mortality in patients with mild to severe chronic kidney disease undergoing coronary angiography: a large multicenter longitudinal study. Int Urol Nephrol. 2023 Dec;55(12):3225-3236. doi: 10.1007/s11255-023-03566-5. Epub 2023 Apr 27.

  PMID: 37103656 DERIVED

MeSH Terms

Conditions

Cardio-Renal Syndrome; Coronary Artery Disease; Kidney Diseases; Metabolic Syndrome; Renal Insufficiency, Chronic

Condition Hierarchy (Ancestors)

Renal Insufficiency; Urologic Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Male Urogenital Diseases; Heart Failure; Heart Diseases; Cardiovascular Diseases; Coronary Disease; Myocardial Ischemia; Arteriosclerosis; Arterial Occlusive Diseases; Vascular Diseases; Insulin Resistance; Hyperinsulinism; Glucose Metabolism Disorders; Metabolic Diseases; Nutritional and Metabolic Diseases; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Yong Liu, MD,PhD

  Guangdong Cardiovascular Institute,Guangdong Provincial People's Hospital

  STUDY DIRECTOR

• Shiqun Chen, MS

  Guangdong Cardiovascular Institute,Guangdong Provincial People's Hospital

  STUDY DIRECTOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Director

Study Record Dates

• First Submitted: September 9, 2021
• First Posted: September 21, 2021
• Study Start: June 1, 2000
• Primary Completion: December 31, 2020
• Study Completion: December 31, 2020
• Last Updated: September 21, 2021

Record last verified: 2021-09

Locations

CN (1)