Risk Factors and Prognosis of Adverse Cardiovascular and Kidney Events After Coronary Intervention

NCT04407936 | Completed DMC

• 1 other identifier: GDREC2019555H
• Study Type: observational
• Target: 88,938
• Locations: 1 country
• Sites: 1

Brief Summary

As a single center, retrospective observation study in Guangdong Institute of Cardiovascular Diseases, this study included the main study population of patients who underwent coronary angiography and / or coronary intervention from January 2007 to Decemeber 2018. The hospitalization information was collected in the form of direct derivation of the case, and cardiac and renal adverse events were collected through outpatient recorder system. All-cause death information was obtained from the Public Security and matched to the electronic Clinical Management System of the Guangdong Provincial People's Hospital records.

Conditions

Cardio-Renal Syndrome; Coronary Angiography; Coronary Artery Disease; Kidney Diseases; Metabolic Syndrome

Keywords

contrast-induced acute kidney injury; contrast medium; creatinine clearance; coronary angiography; chronic kidney disease; Adverse Cardiovascular and Kidney Events

Outcome Measures

Primary Outcomes (1)

• All-cause mortality

  Admission Patients Died for all-cause mortality within 13 years.

  From hospital admission to 13 years follow-up

Secondary Outcomes (6)

• Contrast-Induced Acute Kidney Injury (CI-AKI 0.3)

  48 hours

• Cystatin C based CI-AKI (CI-AKI cyc)

  24-48 hours

• The change of eGFR, calculate based on CrCl and serum cystatin C

  48-72 hours

• Contrast-induced Persistent kidney injury (CI-PKI)

  3 months

• Incidence of major adverse cardiovascular events

  3-12months

Study Arms (1)

coronary angiography

The investigators recruit all consecutive patients who were undergoing coronary angiography or percutaneous coronary intervention

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

The investigators reviewed all consecutive patients who were undergoing coronary angiography

You may qualify if:

• \. Patients referred to CAG or PCI;

Sponsors & Collaborators

• Guangdong Provincial People's Hospital: lead

Study Sites (1)

Guangdong Provincial People's Hospital

Guangzhou, Guangdong, 510080, China

Location

Related Publications (10)

• Chen S, Huang Z, Liang Y, Zhao X, Aobuliksimu X, Wang B, He Y, Kang Y, Huang H, Li Q, Yao Y, Lu X, Qian X, Xie X, Liu J, Liu Y. Five-year mortality of heart failure with preserved, mildly reduced, and reduced ejection fraction in a 4880 Chinese cohort. ESC Heart Fail. 2022 Aug;9(4):2336-2347. doi: 10.1002/ehf2.13921. Epub 2022 Apr 18.

  PMID: 35437939 DERIVED

• Lai W, Zhao X, Yu S, Mai Z, Zhou Y, Huang Z, Li Q, Huang H, Li H, Wei H, Guo D, Xie Y, Li S, Lu H, Liu J, Chen S, Liu Y. Chronic Kidney Disease Increases Risk of Incident HFrEF Following Percutaneous Coronary Intervention. Front Cardiovasc Med. 2022 Apr 1;9:856602. doi: 10.3389/fcvm.2022.856602. eCollection 2022.

  PMID: 35433884 DERIVED

• Huang H, Liu J, Bao K, Huang X, Huang D, Wei H, Remutula N, Tuersun T, Lai W, Li Q, Wang B, He Y, Yang H, Chen S, Chen J, Chen K, Tan N, Wang X, Chen L, Liu Y. Prevalence and Mortality of Moderate or Severe Mitral Regurgitation Among Patients Undergoing Percutaneous Coronary Intervention With or Without Heart Failure: Results From CIN Study With 28,358 Patients. Front Cardiovasc Med. 2022 Mar 3;9:796447. doi: 10.3389/fcvm.2022.796447. eCollection 2022.

  PMID: 35310981 DERIVED

• Chen L, Huang Z, Zhao X, Liang J, Lu X, He Y, Kang Y, Xie Y, Liu J, Liu Y, Yang J, Yu W, Deng W, Pan Y, Lu J, Yang Y, Xie X, Qian X, Xu Q, Chen L, Chen K, Chen S. Predictors and Mortality for Worsening Left Ventricular Ejection Fraction in Patients With HFpEF. Front Cardiovasc Med. 2022 Feb 24;9:820178. doi: 10.3389/fcvm.2022.820178. eCollection 2022.

  PMID: 35282383 DERIVED

• Liu J, Huang Z, Huang H, He Y, Yu Y, Chen G, Liu L, Wang B, Li Q, Lai W, Xu D, Lu J, Yang Y, Chen L, Chen K, Tan N, Chen J, Chen S, Liu Y. Malnutrition in patients with coronary artery disease: Prevalence and mortality in a 46,485 Chinese cohort study. Nutr Metab Cardiovasc Dis. 2022 May;32(5):1186-1194. doi: 10.1016/j.numecd.2021.12.023. Epub 2022 Jan 6.

  PMID: 35260308 DERIVED

• Chen S, Huang Z, Chen L, Zhao X, Kang Y, Lai W, Lu X, Zhou Y, He Y, Huang H, Li Q, Liu J, Liang Y, Dong S, Tan N, Liu Y, Chen J. Does Diabetes Mellitus Increase the Short- and Long-Term Mortality in Patients With Critical Acute Myocardial Infarction? Results From American MIMIC-III and Chinese CIN Cohorts. Front Endocrinol (Lausanne). 2021 Dec 14;12:797049. doi: 10.3389/fendo.2021.797049. eCollection 2021.

  PMID: 34970227 DERIVED

• Huang Z, Yang Y, Lu J, Liang J, He Y, Yu Y, Huang H, Li Q, Wang B, Li S, Yan Z, Xu D, Liu Y, Chen K, Huang Z, Ni J, Liu J, Chen L, Chen S. Association of Lipoprotein(a)-Associated Mortality and the Estimated Glomerular Filtration Rate Level in Patients Undergoing Coronary Angiography: A 51,500 Cohort Study. Front Cardiovasc Med. 2021 Nov 17;8:747120. doi: 10.3389/fcvm.2021.747120. eCollection 2021.

  PMID: 34869651 DERIVED

• Wang B, Guo Z, Liu J, Li H, Mai Z, Lin F, Ying M, Yu Y, Chen S, Li Q, Huang H, Wei W, Yang Y, Dong S, Zhou Y, Chen J, Tan N, Liu Y. Mild Malnutrition Contributes the Greatest to the Poor Prognosis in Coronary Artery Disease With Well-Controlled Low-Density Lipoprotein Cholesterol Levels: A 4,863 Chinese Cohort Study. Front Nutr. 2021 Sep 29;8:725537. doi: 10.3389/fnut.2021.725537. eCollection 2021.

  PMID: 34660661 DERIVED

• Mai Z, Huang Z, Lai W, Li H, Wang B, Huang S, Shi Y, Yu S, Hu Q, Liu J, Zhang L, Liu Y, Chen J, Liang Y, Zhong S, Chen S. Association of Malnutrition, Left Ventricular Ejection Fraction Category, and Mortality in Patients Undergoing Coronary Angiography: A Cohort With 45,826 Patients. Front Nutr. 2021 Sep 16;8:740746. doi: 10.3389/fnut.2021.740746. eCollection 2021.

  PMID: 34604285 DERIVED

• Liu J, Li Q, Lai D, Chen G, Wang B, Liu L, Huang H, Lun Z, Ying M, Chen G, Huang Z, Xu D, Meng L, Yan X, Qiu W, Tan N, Chen J, Liu Y, Chen S. Trends in incidence and long-term prognosis of acute kidney injury following coronary angiography in Chinese cohort with 11,943 patients from 2013 to 2017: an observational study. BMC Nephrol. 2021 Jun 25;22(1):235. doi: 10.1186/s12882-021-02427-6.

  PMID: 34172005 DERIVED

MeSH Terms

Conditions

Cardio-Renal Syndrome; Coronary Artery Disease; Kidney Diseases; Metabolic Syndrome; Renal Insufficiency, Chronic

Condition Hierarchy (Ancestors)

Renal Insufficiency; Urologic Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Male Urogenital Diseases; Heart Failure; Heart Diseases; Cardiovascular Diseases; Coronary Disease; Myocardial Ischemia; Arteriosclerosis; Arterial Occlusive Diseases; Vascular Diseases; Insulin Resistance; Hyperinsulinism; Glucose Metabolism Disorders; Metabolic Diseases; Nutritional and Metabolic Diseases; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Liu Yong, MD,PhD

  Guangdong Cardiovascular Institute,Guangdong Provincial People's Hospital

  STUDY DIRECTOR

• Shiqun Chen, MS

  Guangdong Cardiovascular Institute,Guangdong Provincial People's Hospital

  STUDY DIRECTOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Director

Study Record Dates

• First Submitted: April 14, 2020
• First Posted: May 29, 2020
• Study Start: June 1, 2007
• Primary Completion: December 31, 2018
• Study Completion: March 10, 2020
• Last Updated: September 14, 2021

Record last verified: 2021-09

Locations

CN (1)