Efficacy and Safety of Finerenone in Subjects With Type 2 Diabetes Mellitus and Diabetic Kidney Disease
FIDELIO-DKD
A Randomized, Double-blind, Placebo-controlled, Parallel-group, Multicenter, Event-driven Phase 3 Study to Investigate the Safety and Efficacy of Finerenone, in Addition to Standard of Care, on the Progression of Kidney Disease in Subjects With Type 2 Diabetes Mellitus and the Clinical Diagnosis of Diabetic Kidney Disease
2 other identifiers
interventional
5,734
47 countries
965
Brief Summary
The primary objective of this study was to demonstrate whether, in addition to standard of care, finerenone is superior to placebo in delaying the progression of kidney disease, as measured by the composite endpoint of time to first occurrence of kidney failure, a sustained decrease of estimated glomerular filtration rate (eGFR) ≥40% from baseline over at least 4 weeks, or renal death.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for phase_3
Started Sep 2015
Longer than P75 for phase_3
965 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
September 2, 2015
CompletedFirst Posted
Study publicly available on registry
September 4, 2015
CompletedStudy Start
First participant enrolled
September 17, 2015
CompletedPrimary Completion
Last participant's last visit for primary outcome
April 14, 2020
CompletedStudy Completion
Last participant's last visit for all outcomes
April 14, 2020
CompletedResults Posted
Study results publicly available
July 19, 2021
CompletedJuly 24, 2023
July 1, 2023
4.6 years
September 2, 2015
April 5, 2021
July 20, 2023
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
The First Occurrence of the Composite Endpoint of Onset of Kidney Failure, a Sustained Decrease of eGFR ≥40% From Baseline Over at Least 4 Weeks, or Renal Death
Count of participants and time from randomization to the first occurrence of the primary renal composite outcome, onset of kidney failure, a sustained decrease of eGFR ≥40% from baseline over at least 4 weeks, or renal death were evaluated. Number of participants with the outcome event is reported as descriptive result and hazard ratio is reported as statistical analysis.
From randomization up until the first occurrence of the primary renal composite endpoint, or censoring at the end of the study, with an average follow-up time of 32 months
Secondary Outcomes (5)
The First Occurrence of the Composite Endpoint of Cardiovascular Death, Non-fatal Myocardial Infarction, Non-fatal Stroke, or Hospitalization for Heart Failure
From randomization up until the first occurrence of the key secondary CV composite endpoint, or censoring at the end of the study, with an average of 32 months
All-cause Mortality
From randomization up until death due to any cause, or censoring at the end of the study visit, with an average of 32 months
All-cause Hospitalization
From randomization up until the first occurrence of the hospitalization due to any cause, or censoring at the end of study, with an average of 32 months
Change in Urinary Albumin-to-creatinine Ratio (UACR) From Baseline to Month 4
From baseline up until Month 4
The First Occurrence of the Composite Endpoint of Onset of Kidney Failure, a Sustained Decrease in eGFR of ≥57% From Baseline Over at Least 4 Weeks, or Renal Death
From randomization up until the first occurrence of the composite primary endpoint, or censoring at the end of the study, with an average of 32 months
Study Arms (2)
Finerenone (BAY94-8862)
EXPERIMENTALParticipants received finerenone 10 mg or 20 mg once daily in addition to standard of care therapy
Placebo
PLACEBO COMPARATORParticipants received matching placebo once daily in addition to standard of care therapy
Interventions
Oral tablet; starting dose at 10 mg for subjects with an eGFR between 25 to \< 60 mL/min/1.73m² at the Screening Visit; starting dose at 20 mg for subjects with an eGFR ≥ 60 mL/min/1.73m² at the Screening Visit; dose could be up-titrated from Month 1 onwards or down-titrated at any time during the study; once daily in the morning, until the trial was completed provided there were no safety grounds for discontinuing treatment
Matching placebo, oral tablet, once daily in the morning, until the trial was completed provided there were no safety grounds for discontinuing treatment
Eligibility Criteria
You may qualify if:
- Men or women ≥18 years of age
- Type 2 diabetes mellitus (T2D) as defined by the American Diabetes Association
- Diagnosis of chronic kidney disease (CKD) with at least one of the following criteria at run-in and screening visits:
- persistent high albuminuria (UACR ≥30 to \<300 mg/g in 2 out of 3 first morning void samples) and estimated glomerular filtration rate (eGFR) ≥25 but \<60 mL/min/1.73 m² (CKD EPI) and presence of diabetic retinopathy or
- persistent very high albuminuria (UACR ≥300 mg/g in 2 out of 3 first morning void samples) and eGFR ≥25 to \<75 mL/min/1.73 m² (CKD-EPI)
- Prior treatment with angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) as follows:
- For at least 4 weeks prior to the run-in visit, subjects should be treated with either an ACEI or ARB, or both
- Starting with the run-in visit, subjects should be treated with only an ACEI or ARB
- For at least 4 weeks prior to the screening visit, subjects should be treated with the maximum tolerated labeled dose (but not below the minimal labeled dose) of only an ACEI or an ARB (not both) preferably without any adjustments to dose or choice of agent or to any other antihypertensive or antiglycemic treatment
- Serum potassium ≤4.8 mmol/L at both the run-in and the screening visit
You may not qualify if:
- Known significant non-diabetic renal disease, including clinically relevant renal artery stenosis
- Uncontrolled arterial hypertension (ie, mean sitting systolic blood pressure (SBP) ≥170 mmHg, sitting diastolic blood pressure (DBP) ≥110 mmHg at run-in visit, or mean sitting SBP ≥160 mmHg, sitting DBP ≥100 mmHg at screening)
- Glycated hemoglobin (HbA1c) \>12%
- Mean SBP \< 90 mmHg at the run-in visit or at the screening visit
- Clinical diagnosis of chronic heart failure with reduced ejection fraction (HFrEF) and persistent symptoms (New York Heart Association \[NYHA\] class II - IV) at run-in visit (class 1A recommendation for mineralcorticoid receptor antagonists \[MRAs\])
- Stroke, transient ischemic cerebral attack, acute coronary syndrome, or hospitalization for worsening heart failure, in the last 30 days prior to the screening visit
- Dialysis for acute renal failure within 12 weeks of run-in visit
- Renal allograft in place or scheduled within next 12 months from the run-in visit
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Bayerlead
Study Sites (978)
Unknown Facility
Birmingham, Alabama, 35294, United States
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Fort Payne, Alabama, 35967, United States
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Huntsville, Alabama, 35801-4317, United States
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Mesa, Arizona, 85210, United States
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Phoenix, Arizona, 85016, United States
Unknown Facility
Phoenix, Arizona, 85032, United States
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Prescott, Arizona, 86301, United States
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Tucson, Arizona, 85723, United States
Unknown Facility
Tucson, Arizona, 85724, United States
Unknown Facility
Arvin, California, 93203, United States
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Chula Vista, California, 91910, United States
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Dublin, California, 94568, United States
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El Centro, California, 92243, United States
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Fresno, California, 93720, United States
Unknown Facility
Fresno, California, 93721, United States
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La Mesa, California, 91942, United States
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Loma Linda, California, 92357, United States
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Los Angeles, California, 90017, United States
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Los Angeles, California, 90022, United States
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Los Angeles, California, 90025, United States
Unknown Facility
Los Angeles, California, 90073, United States
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Northridge, California, 91325, United States
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Port Hueneme, California, 93041, United States
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Poway, California, 92064, United States
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Rancho Cucamonga, California, 91730, United States
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Rialto, California, 92377, United States
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Roseville, California, 95661, United States
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San Diego, California, 92117, United States
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San Francisco, California, 94110, United States
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Torrance, California, 90502, United States
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New Haven, Connecticut, 06520, United States
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Waterbury, Connecticut, 06708, United States
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Fleming Island, Florida, 32003, United States
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Fort Lauderdale, Florida, 33316-1958, United States
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Gainesville, Florida, 32610-0224, United States
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Hialeah, Florida, 33012, United States
Unknown Facility
Hialeah, Florida, 33016, United States
Unknown Facility
Hollywood, Florida, 33024, United States
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Jacksonville, Florida, 32204, United States
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Miami, Florida, 33032, United States
Unknown Facility
Miami, Florida, 33126, United States
Unknown Facility
Miami, Florida, 33130, United States
Unknown Facility
Miami, Florida, 33144, United States
Unknown Facility
Miami, Florida, 33145, United States
Unknown Facility
Miami, Florida, 33155, United States
Unknown Facility
Miami, Florida, 33156, United States
Unknown Facility
Miami, Florida, 33165, United States
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Miami, Florida, 33173, United States
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Miami, Florida, 33175, United States
Unknown Facility
Miami, Florida, 33180, United States
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Miami, Florida, 33186, United States
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Miami Beach, Florida, 33140, United States
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Miami Gardens, Florida, 33169, United States
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Miami Lakes, Florida, 33014, United States
Unknown Facility
Miami Lakes, Florida, 33016, United States
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New Port Richey, Florida, 34652, United States
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Ocala, Florida, 34471, United States
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Orlando, Florida, 32825, United States
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Palm Harbor, Florida, 34684, United States
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Sarasota, Florida, 34239, United States
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Tampa, Florida, 33614, United States
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Tampa, Florida, 33619, United States
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Winter Haven, Florida, 33880, United States
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Atlanta, Georgia, 30303, United States
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Atlanta, Georgia, 30318, United States
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Atlanta, Georgia, 30342, United States
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Augusta, Georgia, 30904, United States
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Duluth, Georgia, 30096, United States
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Lilburn, Georgia, 30047, United States
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Macon, Georgia, 31210, United States
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Honolulu, Hawaii, 96814, United States
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Chicago, Illinois, 60611, United States
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Chicago, Illinois, 60612, United States
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Elgin, Illinois, 60123, United States
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Indianapolis, Indiana, 46202, United States
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Iowa City, Iowa, 52242, United States
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Hutchinson, Kansas, 67502-1131, United States
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Topeka, Kansas, 66606, United States
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Wichita, Kansas, 67214, United States
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Metairie, Louisiana, 70006, United States
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Monroe, Louisiana, 71201, United States
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New Orleans, Louisiana, 70112, United States
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Shreveport, Louisiana, 71101, United States
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Takoma Park, Maryland, 20912, United States
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Boston, Massachusetts, 02215, United States
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Ann Arbor, Michigan, 48109, United States
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Flint, Michigan, 48504, United States
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Flint, Michigan, 48532, United States
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Minneapolis, Minnesota, 55455, United States
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Columbia, Missouri, 65201, United States
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Columbia, Missouri, 65212, United States
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Jefferson City, Missouri, 65109, United States
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Kansas City, Missouri, 64111, United States
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Kansas City, Missouri, 64128, United States
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St Louis, Missouri, 63106, United States
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St Louis, Missouri, 63136, United States
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Lincoln, Nebraska, 68510, United States
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Omaha, Nebraska, 68124, United States
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Omaha, Nebraska, 68131, United States
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Las Vegas, Nevada, 89086, United States
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Las Vegas, Nevada, 89102, United States
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Las Vegas, Nevada, 89113-2215, United States
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Las Vegas, Nevada, 89119, United States
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Las Vegas, Nevada, 89128, United States
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Reno, Nevada, 89511, United States
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Newark, New Jersey, 07103, United States
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Albuquerque, New Mexico, 87106, United States
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Albany, New York, 12206, United States
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Brooklyn, New York, 11203, United States
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Flushing, New York, 11355, United States
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Mineola, New York, 11501, United States
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New York, New York, 10021, United States
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New York, New York, 10029, United States
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New York, New York, 10032, United States
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Rosedale, New York, 11422, United States
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Smithtown, New York, 11787, United States
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Staten Island, New York, 10301, United States
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Asheboro, North Carolina, 27203, United States
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Chapel Hill, North Carolina, 27312, United States
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Charlotte, North Carolina, 28207, United States
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Greenville, North Carolina, 27834, United States
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New Bern, North Carolina, 28562, United States
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Winston-Salem, North Carolina, 27103, United States
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Winston-Salem, North Carolina, 27157, United States
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Canton, Ohio, 44718, United States
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Cleveland, Ohio, 44106, United States
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Columbus, Ohio, 43210, United States
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Beaver, Pennsylvania, 15009, United States
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Bethlehem, Pennsylvania, 18017, United States
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Hershey, Pennsylvania, 17033, United States
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Lansdale, Pennsylvania, 19446-2321, United States
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Anderson, South Carolina, 29625, United States
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Charleston, South Carolina, 29425, United States
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Greenville, South Carolina, 29605, United States
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Greer, South Carolina, 29651, United States
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Murrells Inlet, South Carolina, 29576, United States
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Orangeburg, South Carolina, 29118, United States
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Chattanooga, Tennessee, 37404, United States
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Memphis, Tennessee, 38120, United States
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Memphis, Tennessee, 38163, United States
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Nashville, Tennessee, 37205, United States
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Nashville, Tennessee, 37208, United States
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Nashville, Tennessee, 37232-1371, United States
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Arlington, Texas, 76014, United States
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Corpus Christi, Texas, 78414-4173, United States
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Dallas, Texas, 75216, United States
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Dallas, Texas, 75246, United States
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Dallas, Texas, 75251, United States
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El Paso, Texas, 79935, United States
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Houston, Texas, 77008, United States
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Houston, Texas, 77024, United States
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Houston, Texas, 77040, United States
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Houston, Texas, 77061, United States
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Houston, Texas, 77079, United States
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Houston, Texas, 77095, United States
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Kingwood, Texas, 77339, United States
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McAllen, Texas, 78503, United States
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McKinney, Texas, 75069-1780, United States
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Pearland, Texas, 77584, United States
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Pflugerville, Texas, 78660, United States
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San Antonio, Texas, 78212, United States
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San Antonio, Texas, 78215, United States
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San Antonio, Texas, 78229-3900, United States
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Sugar Land, Texas, 77478, United States
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Sugar Land, Texas, 77479, United States
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Waco, Texas, 76710, United States
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Salt Lake City, Utah, 84108, United States
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St. George, Utah, 84790, United States
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Burlington, Vermont, 05401, United States
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Alexandria, Virginia, 22304, United States
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Manassas, Virginia, 20110, United States
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Salem, Virginia, 24153, United States
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Virginia Beach, Virginia, 23462, United States
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Spokane Valley, Washington, 99216-3522, United States
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Tacoma, Washington, 98405, United States
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Milwaukee, Wisconsin, 53295, United States
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Junín, Buenos Aires, B6000GMA, Argentina
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Lanús, Buenos Aires, B1824KAJ, Argentina
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Mar del Plata, Buenos Aires, B7602CBM, Argentina
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Sarandí, Buenos Aires, 1872, Argentina
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Buenos Aires, Ciudad Auton. de Buenos Aires, C1056ABJ, Argentina
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Buenos Aires, Ciudad Auton. de Buenos Aires, C1426ABP, Argentina
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Buenos Aires, Ciudad Auton. de Buenos Aires, C1428ART, Argentina
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Buenos Aires, Ciudad Auton. de Buenos Aires, C1429BWN, Argentina
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CABA, Ciudad Auton. de Buenos Aires, C1018DES, Argentina
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Ciudad Autón. de Buenos Aires, Ciudad Auton. de Buenos Aires, C1425AGC, Argentina
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Córdoba, X5000AAW Córdoba, Argentina
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Córdoba, X5000JHQ, Argentina
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San Luis, D5702AAx, Argentina
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Garran, Australian Capital Territory, 2605, Australia
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Gosford, New South Wales, 2250, Australia
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Liverpool, New South Wales, 2170, Australia
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New Lambton, New South Wales, 2305, Australia
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Wollongong, New South Wales, 2500, Australia
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Adelaide, South Australia, 5000, Australia
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Fitzroy, Victoria, 3065, Australia
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Heidelberg, Victoria, 3081, Australia
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Reservoir, Victoria, 3073, Australia
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Richmond, Victoria, 3121, Australia
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St Albans, Victoria, 3021, Australia
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Box Hill, 3128, Australia
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Elizabeth Vale, 5112, Australia
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Graz, Styria, 8036, Austria
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Saint Stefan, Styria, 8511, Austria
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Linz, Upper Austria, 4020, Austria
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Linz, Upper Austria, 4021, Austria
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Feldkirch, Vorarlberg, 6807, Austria
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Innsbruck, 6020, Austria
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Salzburg, 5020, Austria
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Sankt Pölten, 3100, Austria
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Vienna, 1030, Austria
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Vienna, 1060, Austria
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Vienna, 1090, Austria
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Vienna, 1130, Austria
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Wels, 4600, Austria
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Antwerp, 2060, Belgium
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Bruxelles - Brussel, 1070, Belgium
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Edegem, 2650, Belgium
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Ghent, 9000, Belgium
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Ieper, 8900, Belgium
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Kortrijk, 8500, Belgium
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Leuven, 3000, Belgium
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Liège, 4000, Belgium
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Roeselare, 8800, Belgium
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Fortaleza, Ceará, 60115-282, Brazil
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Fortaleza, Ceará, 60430-140, Brazil
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Fortaleza, Ceará, Brazil
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Feira de Santana, Estado de Bahia, 44001-584, Brazil
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Salvador, Estado de Bahia, 40415-065, Brazil
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Brasília, Federal District, 70.200-730, Brazil
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Aparecida de Goiânia, Goiás, 74935-530, Brazil
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Goiânia, Goiás, 74605-020, Brazil
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Juiz de Fora, Minas Gerais, 36036-330, Brazil
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Curitiba, Paraná, 80030-110, Brazil
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Curitiba, Paraná, 80230-130, Brazil
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Curitiba, Paraná, 80440-020, Brazil
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Paraná, Paraná, 83430-000, Brazil
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Porto Alegre, Rio Grande do Sul, 90430-001, Brazil
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Porto Alegre, Rio Grande do Sul, 90610-000, Brazil
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Santo André, São Paulo, Brazil
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São José do Rio Preto, São Paulo, 15090-000, Brazil
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São José dos Campos, São Paulo, 12243-280, Brazil
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São Paulo, São Paulo, Brazil
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Minas Gerais, 38400-368, Brazil
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Rio de Janeiro, 20241-180, Brazil
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Rio de Janeiro, 21941-913, Brazil
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São Paulo, 01223-001, Brazil
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São Paulo, 01228-200, Brazil
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São Paulo, 04039-000, Brazil
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Blagoevgrad, 2700, Bulgaria
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Botevgrad, 2140, Bulgaria
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Dimitrovgrad, 6400, Bulgaria
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Gorna Oryahovitsa, 5100, Bulgaria
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Kazanlak, 6102, Bulgaria
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Kozloduy, 3320, Bulgaria
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Lukovit, 5770, Bulgaria
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Plovdiv, 4000, Bulgaria
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Plovdiv, 4002, Bulgaria
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Plovdiv, 4004, Bulgaria
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Razgrad, 7200, Bulgaria
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Sliven, 8800, Bulgaria
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Smolyan, 4700, Bulgaria
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Sofia, 1233, Bulgaria
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Sofia, 1407, Bulgaria
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Sofia, 1431, Bulgaria
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Sofia, 1680, Bulgaria
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Stara Zagora, 6000, Bulgaria
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Varna, 9000, Bulgaria
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Yambol, 8600, Bulgaria
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Burnaby, British Columbia, V3J 1N4, Canada
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Coquitlam, British Columbia, V3K 3P4, Canada
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New Westminster, British Columbia, V3L 0A6, Canada
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Mount Pearl, Newfoundland and Labrador, A1N 2C3, Canada
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St. John's, Newfoundland and Labrador, A1A 3R5, Canada
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Halifax, Nova Scotia, B3H 1V8, Canada
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Cambridge, Ontario, N1R 7L6, Canada
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Greater Sudbury, Ontario, P3A 1W8, Canada
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Hamilton, Ontario, L8M 1K7, Canada
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Hamilton, Ontario, L8N 4A6, Canada
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Kitchener, Ontario, N2G 4V5, Canada
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Newmarket, Ontario, L3Y 5G8, Canada
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Oshawa, Ontario, L1G 2B9, Canada
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Ottawa, Ontario, K1K 4L2, Canada
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Sarnia, Ontario, N7T 4X3, Canada
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Smith Falls, Ontario, K7A 4W8, Canada
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Thornhill, Ontario, L4J 1W3, Canada
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Toronto, Ontario, M4G 3E8, Canada
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Toronto, Ontario, M5C 2T2, Canada
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Waterloo, Ontario, N2J 1C4, Canada
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Greenfield Park, Quebec, J4V 2H1, Canada
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Laval, Quebec, H7T 2P5, Canada
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Mirabel, Quebec, J7J 2K8, Canada
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Montreal, Quebec, H1M 1B1, Canada
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Montreal, Quebec, H2K 1H2, Canada
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Montreal, Quebec, H3G 1A4, Canada
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Montreal, Quebec, H4A 3J1, Canada
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Montreal, Quebec, H4A 3T2, Canada
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Montreal, Quebec, QC H4J 1C5, Canada
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Québec, G1V 4W2, Canada
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Osorno, Los Lagos Region, 5311092, Chile
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Las Condes, Santiago Metropolitan, 7591047, Chile
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Providencia, Santiago Metropolitan, 7500520, Chile
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Providencia, Santiago Metropolitan, 7500710, Chile
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Providencia, Santiago Metropolitan, 7500922, Chile
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San Bernardo, Santiago Metropolitan, 8053095, Chile
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San Miguel, Santiago Metropolitan, 8910108, Chile
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Santiago, 8330008, Chile
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Santiago, 8331143, Chile
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Santiago, 8380456, Chile
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Fuzhou, Fujian, 350025, China
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Xiamen, Fujian, 361003, China
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Xiamen, Fujian, 361004, China
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Lanzhou, Gansu, 730030, China
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Guangzhou, Guangdong, 510080, China
Unknown Facility
Guangzhou, Guangdong, 510120, China
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Guangzhou, Guangdong, 510150, China
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Guangzhou, Guangdong, 510405, China
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Guangzhou, Guangdong, 510630, China
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Zhuhai, Guangdong, 519000, China
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Nanning, Guangxi, 530021, China
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Nanning, Guangxi, 530031, China
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Haikou, Hainan, 570102, China
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Haikou, Hainan, 570311, China
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Wuhan, Hubei, 430022, China
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Wuhan, Hubei, 430034, China
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Changsha, Hunan, 410000, China
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Changsha, Hunan, 410008, China
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Changsha, Hunan, 410011, China
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Changzhou, Jiangsu, 213004, China
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Huai'an, Jiangsu, 223300, China
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Lianyungang, Jiangsu, 222002, China
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Nanjing, Jiangsu, 210000, China
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Nanjing, Jiangsu, 210006, China
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Nanjing, Jiangsu, 210008, China
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Nanjing, Jiangsu, 210029, China
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Suzhou, Jiangsu, 215006, China
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Wuxi, Jiangsu, 214023, China
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Yancheng, Jiangsu, 224000, China
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Nanchang, Jiangxi, 330006, China
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Nanchang, Jiangxi, 330008, China
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Changchun, Jilin, 130000, China
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Shenyang, Liaoning, 110016, China
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Shenyang, Liaoning, 110022, China
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Yinchuan, Ningxia, 750004, China
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Xi'an, Shaanxi, 710061, China
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Qingdao, Shandong, 266000, China
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Qingdao, Shandong, 266071, China
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Taiyuan, Shanxi, 030001, China
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Chengdu, Sichuan, 610041, China
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Chengdu, Sichuan, 610072, China
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Hangzhou, Zhejiang, 310013, China
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Taizhou, Zhejiang, 317000, China
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Wenzhou, Zhejiang, 325000, China
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Beijing, 100010, China
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Beijing, 100730, China
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Chongqing, 400010, China
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Shanghai, 200025, China
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Shanghai, 200040, China
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Shanghai, 200072, China
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Shanghai, 200092, China
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Shanghai, 200240, China
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Shanghai, 200333, China
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Shanghai, 201199, China
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Tianjin, 300052, China
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Tianjin, 300121, China
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Tianjin, 300142, China
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Medellín, Antioquia, 050023, Colombia
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Medellín, Antioquia, 050034, Colombia
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Medellín, Antioquia, 0, Colombia
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Medellín, Antioquia, Colombia
Unknown Facility
Baranquilla, Atlántico, 080020, Colombia
Unknown Facility
Barranquilla, Atlántico, 080020, Colombia
Unknown Facility
Barranquilla, Atlántico, 0, Colombia
Unknown Facility
Bogotá, Bogota D.C., 0, Colombia
Unknown Facility
Cundinamarca, Bogota D.C., Colombia
Unknown Facility
Manizales, Caldas Department, Colombia
Unknown Facility
Zipaquirá, Cundinamarca, 250252, Colombia
Unknown Facility
Armenia, Quindío Department, 0, Colombia
Unknown Facility
Cali, Valle del Cauca Department, 760032, Colombia
Unknown Facility
Cali, Valle del Cauca Department, Colombia
Unknown Facility
Floridablanca, Colombia
Unknown Facility
Medellín, Colombia
Unknown Facility
Beroun, 266 01, Czechia
Unknown Facility
Brandýs nad Labem, 250 01, Czechia
Unknown Facility
Břeclav, 690 02, Czechia
Unknown Facility
Česká Lípa, 470 01, Czechia
Unknown Facility
Český Krumlov, 381 01, Czechia
Unknown Facility
Český Krumlov, 381 27, Czechia
Unknown Facility
Frýdek-Místek, 738 01, Czechia
Unknown Facility
Hodonín, 695 01, Czechia
Unknown Facility
Holešov, 769 01, Czechia
Unknown Facility
Hranice, 753 01, Czechia
Unknown Facility
Kopřivnice, 742 21, Czechia
Unknown Facility
Krnov, 794 01, Czechia
Unknown Facility
Mladá Boleslav, 29301, Czechia
Unknown Facility
Olomouc, 779 00, Czechia
Unknown Facility
Olomouc, 77900, Czechia
Unknown Facility
Ostrava, 702 00, Czechia
Unknown Facility
Pilsen, 301 66, Czechia
Unknown Facility
Prague, 12808, Czechia
Unknown Facility
Prague, 140 00, Czechia
Unknown Facility
Prague, 140 46, Czechia
Unknown Facility
Prague, 150 00, Czechia
Unknown Facility
Prague, 169 00, Czechia
Unknown Facility
Vlašim, 258 01, Czechia
Unknown Facility
Aalborg, 9000, Denmark
Unknown Facility
Aarhus N, 8200, Denmark
Unknown Facility
Esbjerg, 6700, Denmark
Unknown Facility
Hellerup, 2900, Denmark
Unknown Facility
Herlev, 2730, Denmark
Unknown Facility
Hillerød, 3400, Denmark
Unknown Facility
Holbæk, 4300, Denmark
Unknown Facility
Holstebro, DK-7500, Denmark
Unknown Facility
Hvidovre, 2650, Denmark
Unknown Facility
Kolding, 6000, Denmark
Unknown Facility
København NV, 2400, Denmark
Unknown Facility
Odense C, DK-5000, Denmark
Unknown Facility
Svendborg, 5700, Denmark
Unknown Facility
Viborg, 8800, Denmark
Unknown Facility
Jyväskylä, 40620, Finland
Unknown Facility
Kajaani, 87140, Finland
Unknown Facility
Kerava, 04200, Finland
Unknown Facility
Klaukkala, 01800, Finland
Unknown Facility
Kuopio, 70100, Finland
Unknown Facility
Nurmijärvi, 01900, Finland
Unknown Facility
Oulu, 90100, Finland
Unknown Facility
Rauma, 26100, Finland
Unknown Facility
Seinäjoki, 60100, Finland
Unknown Facility
Tampere, 33520, Finland
Unknown Facility
Turku, 20521, Finland
Unknown Facility
Vantaa, 01600, Finland
Unknown Facility
Bois-Guillaume, 76230, France
Unknown Facility
Bordeaux, 33000, France
Unknown Facility
Boulogne-sur-Mer, 62321, France
Unknown Facility
Brest, 29200, France
Unknown Facility
Colmar, 68024, France
Unknown Facility
Dijon, 21000, France
Unknown Facility
La Rochelle, 17019, France
Unknown Facility
La Tronche, 38700, France
Unknown Facility
Le Coudray, 28630, France
Unknown Facility
Le Creusot, 71200, France
Unknown Facility
Lyon, 69437, France
Unknown Facility
Mulhouse, 68051, France
Unknown Facility
Nîmes, 30029, France
Unknown Facility
Paris, 75018, France
Unknown Facility
Pessac, 33608, France
Unknown Facility
Saint-Herblain, 44093, France
Unknown Facility
Saint-Priest-en-Jarez, 42270, France
Unknown Facility
Tourcoing, 59280, France
Unknown Facility
Vandœuvre-lès-Nancy, 54500, France
Unknown Facility
Vénissieux, 69200, France
Unknown Facility
Heidelberg, Baden-Wurttemberg, 69115, Germany
Unknown Facility
Ludwigsburg, Baden-Wurttemberg, 71640, Germany
Unknown Facility
Schweinfurt, Bavaria, 97421, Germany
Unknown Facility
Würzburg, Bavaria, 97080, Germany
Unknown Facility
Elsterwerda, Brandenburg, 04910, Germany
Unknown Facility
Bad König, Hesse, 64732, Germany
Unknown Facility
Frankfurt am Main, Hesse, 60313, Germany
Unknown Facility
Frankfurt am Main, Hesse, 60596, Germany
Unknown Facility
Göttingen, Lower Saxony, 37075, Germany
Unknown Facility
Hanover, Lower Saxony, 30625, Germany
Unknown Facility
Aachen, North Rhine-Westphalia, 52074, Germany
Unknown Facility
Bad Oeynhausen, North Rhine-Westphalia, 32545, Germany
Unknown Facility
Bochum, North Rhine-Westphalia, 44787, Germany
Unknown Facility
Dortmund, North Rhine-Westphalia, 44137, Germany
Unknown Facility
Düsseldorf, North Rhine-Westphalia, 40210, Germany
Unknown Facility
Düsseldorf, North Rhine-Westphalia, 40225, Germany
Unknown Facility
Essen, North Rhine-Westphalia, 45136, Germany
Unknown Facility
Münster, North Rhine-Westphalia, 48145, Germany
Unknown Facility
Nettetal, North Rhine-Westphalia, 41334, Germany
Unknown Facility
Witten, North Rhine-Westphalia, 58455, Germany
Unknown Facility
Ludwigshafen am Rhein, Rhineland-Palatinate, 67059, Germany
Unknown Facility
Mainz, Rhineland-Palatinate, 55128, Germany
Unknown Facility
Dresden, Saxony, 01277, Germany
Unknown Facility
Dresden, Saxony, 01307, Germany
Unknown Facility
Hoyerswerda, Saxony, 02977, Germany
Unknown Facility
Leipzig, Saxony, 04103, Germany
Unknown Facility
Leipzig, Saxony, 04249, Germany
Unknown Facility
Jena, Thuringia, 07747, Germany
Unknown Facility
Berlin, 10437, Germany
Unknown Facility
Berlin, 12203, Germany
Unknown Facility
Berlin, 13187, Germany
Unknown Facility
Berlin, 13347, Germany
Unknown Facility
Hamburg, 22041, Germany
Unknown Facility
Alexandroupoli, 68100, Greece
Unknown Facility
Athens, 11527, Greece
Unknown Facility
Athens, 14455, Greece
Unknown Facility
Chaïdári, 12462, Greece
Unknown Facility
Larissa, 41100, Greece
Unknown Facility
Nea Ionia, 14233, Greece
Unknown Facility
Thessaloniki, 54642, Greece
Unknown Facility
Thessaloniki, 56403, Greece
Unknown Facility
Hong Kong, Hong Kong
Unknown Facility
Shatin, Hong Kong
Unknown Facility
Sheung Wan, Hong Kong
Unknown Facility
Wong Tai Sin, Hong Kong
Unknown Facility
Baja, 6500, Hungary
Unknown Facility
Balatonfüred, 8230, Hungary
Unknown Facility
Budapest, 1036, Hungary
Unknown Facility
Budapest, 1042, Hungary
Unknown Facility
Budapest, 1088, Hungary
Unknown Facility
Budapest, 1089, Hungary
Unknown Facility
Budapest, 1134, Hungary
Unknown Facility
Budapest, 1135, Hungary
Unknown Facility
Debrecen, 4031, Hungary
Unknown Facility
Eger, 3300, Hungary
Unknown Facility
Kistarcsa, 2143, Hungary
Unknown Facility
Nyíregyháza, 4400, Hungary
Unknown Facility
Nyíregyháza, 4405, Hungary
Unknown Facility
Pápa, 8500, Hungary
Unknown Facility
Siófok, 8600, Hungary
Unknown Facility
Szeged, Hungary
Unknown Facility
Szentes, 6600, Hungary
Unknown Facility
Székesfehérvár, 8000, Hungary
Unknown Facility
Szombathely, 9700, Hungary
Unknown Facility
Veszprém, 8200, Hungary
Unknown Facility
Cork, Ireland
Unknown Facility
Dublin, D07 R2WY, Ireland
Unknown Facility
Dublin, DUBLIN 4, Ireland
Unknown Facility
Galway, Ireland
Unknown Facility
Afula, 1834111, Israel
Unknown Facility
Ashkelon, 7830604, Israel
Unknown Facility
Beersheba, 8410101, Israel
Unknown Facility
Hadera, 3810101, Israel
Unknown Facility
Haifa, 3109601, Israel
Unknown Facility
Holon, 5822012, Israel
Unknown Facility
Jerusalem, 9112001, Israel
Unknown Facility
Kfar Saba, 4428164, Israel
Unknown Facility
Nahariya, 2210001, Israel
Unknown Facility
Nahariya, 22100, Israel
Unknown Facility
Nazareth, 16100, Israel
Unknown Facility
Ramat Gan, 5262000, Israel
Unknown Facility
Rehovot, 7610001, Israel
Unknown Facility
Safed, 1311001, Israel
Unknown Facility
Sakhnin, 3081000, Israel
Unknown Facility
Tel Aviv, 6203854, Israel
Unknown Facility
Tel Aviv, 6423906, Israel
Unknown Facility
Tel Aviv, 6905234, Israel
Unknown Facility
Tel Aviv, 6937947, Israel
Unknown Facility
Tiberias, 1528001, Israel
Unknown Facility
Ẕerifin, 7030000, Israel
Unknown Facility
Napoli, Campania, 80131, Italy
Unknown Facility
Bologna, Emilia-Romagna, 40138, Italy
Unknown Facility
Parma, Emilia-Romagna, 43126, Italy
Unknown Facility
Reggio Emilia, Emilia-Romagna, 42123, Italy
Unknown Facility
Genoa, Liguria, 16011, Italy
Unknown Facility
Genoa, Liguria, 16132, Italy
Unknown Facility
Bergamo, Lombardy, 24020, Italy
Unknown Facility
Bergamo, Lombardy, 24047, Italy
Unknown Facility
Bergamo, Lombardy, 24127, Italy
Unknown Facility
Milan, Lombardy, 20024, Italy
Unknown Facility
Milan, Lombardy, 20132, Italy
Unknown Facility
Milan, Lombardy, 20142, Italy
Unknown Facility
Milan, Lombardy, 20157, Italy
Unknown Facility
Monza Brianza, Lombardy, 20832, Italy
Unknown Facility
Turin, Piedmont, 10023, Italy
Unknown Facility
Turin, Piedmont, 10043, Italy
Unknown Facility
Cagliari, Sardinia, 09134, Italy
Unknown Facility
Sassari, Sardinia, 07026, Italy
Unknown Facility
Catania, Sicily, 95124, Italy
Unknown Facility
Messina, Sicily, 98125, Italy
Unknown Facility
Padua, Veneto, 35128, Italy
Unknown Facility
Verona, Veneto, 37126, Italy
Unknown Facility
Nagoya, Aichi-ken, 451-8511, Japan
Unknown Facility
Nagoya, Aichi-ken, 456-0058, Japan
Unknown Facility
Nagoya, Aichi-ken, 457-8510, Japan
Unknown Facility
Nagoya, Aichi-ken, 460-0001, Japan
Unknown Facility
Nagoya, Aichi-ken, 466-8650, Japan
Unknown Facility
Toyota, Aichi-ken, 471-8513, Japan
Unknown Facility
Funabashi, Chiba, 273-8588, Japan
Unknown Facility
Ichikawa, Chiba, 272-8516, Japan
Unknown Facility
Matsuyama, Ehime, 790-0024, Japan
Unknown Facility
Matsuyama, Ehime, 791-8026, Japan
Unknown Facility
Chikushino-shi, Fukuoka, 818-8502, Japan
Unknown Facility
Kasuga, Fukuoka, 816-0864, Japan
Unknown Facility
Kitakyushu, Fukuoka, 800-0296, Japan
Unknown Facility
Kitakyushu, Fukuoka, 802-8555, Japan
Unknown Facility
Kitakyushu, Fukuoka, 805-8508, Japan
Unknown Facility
Kitakyushu, Fukuoka, 807-0857, Japan
Unknown Facility
Shirakawa, Fukushima, 961-0005, Japan
Unknown Facility
Ōgaki, Gifu, 503-8502, Japan
Unknown Facility
Maebashi, Gunma, 371-0821, Japan
Unknown Facility
Higashihiroshima, Hiroshima, 739-0041, Japan
Unknown Facility
Asahikawa, Hokkaido, 078-8234, Japan
Unknown Facility
Hakodate, Hokkaido, 041-8680, Japan
Unknown Facility
Obihiro, Hokkaido, 080-0848, Japan
Unknown Facility
Sapporo, Hokkaido, 007-0841, Japan
Unknown Facility
Kobe, Hyōgo, 650-0047, Japan
Unknown Facility
Naka, Ibaraki, 311-0113, Japan
Unknown Facility
Ushiku, Ibaraki, 300-1207, Japan
Unknown Facility
Komatsu, Ishikawa-ken, 923-8560, Japan
Unknown Facility
Sanuki, Kagawa-ken, 769-2393, Japan
Unknown Facility
Takamatsu, Kagawa-ken, 760-0017, Japan
Unknown Facility
Takamatsu, Kagawa-ken, 760-0018, Japan
Unknown Facility
Atsugi, Kanagawa, 243-0035, Japan
Unknown Facility
Fujisawa, Kanagawa, 251-0041, Japan
Unknown Facility
Kamakura, Kanagawa, 247-8533, Japan
Unknown Facility
Yokohama, Kanagawa, 235-0045, Japan
Unknown Facility
Yokohama, Kanagawa, 245-8575, Japan
Unknown Facility
Yokohama, Kanagawa, 247-8581, Japan
Unknown Facility
Tamana, Kumamoto, 865-0016, Japan
Unknown Facility
Yatsushiro, Kumamoto, 866-0824, Japan
Unknown Facility
Sasebo, Nagasaki, 857-1195, Japan
Unknown Facility
Beppu, Oita Prefecture, 874-0011, Japan
Unknown Facility
Yufu, Oita Prefecture, 879-5593, Japan
Unknown Facility
Nakagami-gun, Okinawa, 901-2393, Japan
Unknown Facility
Shimajiri, Okinawa, 901-0493, Japan
Unknown Facility
Suita, Osaka, 565-0862, Japan
Unknown Facility
Kawaguchi, Saitama, 332-0012, Japan
Unknown Facility
Sayama, Saitama, 350-1305, Japan
Unknown Facility
Ōtsu, Shiga, 520-0804, Japan
Unknown Facility
Iwata, Shizuoka, 438-8550, Japan
Unknown Facility
Oyama, Tochigi, 323-0022, Japan
Unknown Facility
Minato, Tokyo, 108-0073, Japan
Unknown Facility
Musashino, Tokyo, 180-8610, Japan
Unknown Facility
Shibuya-ku, Tokyo, 150-0002, Japan
Unknown Facility
Fukui, 910-8526, Japan
Unknown Facility
Fukui, 918-8503, Japan
Unknown Facility
Fukuoka, 811-0213, Japan
Unknown Facility
Fukuoka, 814-0180, Japan
Unknown Facility
Fukuoka, 815-8555, Japan
Unknown Facility
Kagoshima, 890-8760, Japan
Unknown Facility
Kumamoto, 861-4193, Japan
Unknown Facility
Kumamoto, 861-8520, Japan
Unknown Facility
Kumamoto, 862-0976, Japan
Unknown Facility
Nagasaki, 852-8511, Japan
Unknown Facility
Osaka, 530-0001, Japan
Unknown Facility
Osaka, 530-8480, Japan
Unknown Facility
Osaka, 543-0035, Japan
Unknown Facility
Osaka, 553-0003, Japan
Unknown Facility
Osaka, 558-8558, Japan
Unknown Facility
Saitama, 331-8577, Japan
Unknown Facility
Kaunas, LT-45217, Lithuania
Unknown Facility
Kaunas, LT-48259, Lithuania
Unknown Facility
Kaunas, LT-49449, Lithuania
Unknown Facility
Klaipėda, LT-92304, Lithuania
Unknown Facility
Utena, LT-28142, Lithuania
Unknown Facility
Vilnius, LT-08661, Lithuania
Unknown Facility
Johor Bahru, 80100, Malaysia
Unknown Facility
Kelantan, 15200, Malaysia
Unknown Facility
Kelantan, Malaysia
Unknown Facility
Kuala Lumpur, 59100, Malaysia
Unknown Facility
Kuala Pahang, 25100, Malaysia
Unknown Facility
Kuala Selangor, 47000, Malaysia
Unknown Facility
Perak, 30450, Malaysia
Unknown Facility
Perak, 32040, Malaysia
Unknown Facility
Pulau Pinang, 10450, Malaysia
Unknown Facility
Putrajaya, 62250, Malaysia
Unknown Facility
Guadalajara, Jalisco, 44600, Mexico
Unknown Facility
Guadalajara, Jalisco, 44657, Mexico
Unknown Facility
Mexico City, Mexico City, 6700, Mexico
Unknown Facility
México D.F., Mexico City, 14080, Mexico
Unknown Facility
México, D. F., Mexico City, 11850, Mexico
Unknown Facility
México, D. F., Mexico City, 3100, Mexico
Unknown Facility
Cuernavaca, Morelos, 62250, Mexico
Unknown Facility
Querétaro City, Querétaro, 76000, Mexico
Unknown Facility
San Juan del Río, Querétaro, 76800, Mexico
Unknown Facility
Culiacán, Sinaloa, 80200, Mexico
Unknown Facility
Culiacán, Sinaloa, 80230, Mexico
Unknown Facility
Mazatlán, Sinaloa, 82110, Mexico
Unknown Facility
Puerto de Veracruz, Veracruz, 91900, Mexico
Unknown Facility
Xalapa, Veracruz, 91193, Mexico
Unknown Facility
Aguascalientes, 20219, Mexico
Unknown Facility
Chihuahua City, 31238, Mexico
Unknown Facility
Mexico City, 06726, Mexico
Unknown Facility
Alkmaar, 1815 JD, Netherlands
Unknown Facility
Almere Stad, 1315 RA, Netherlands
Unknown Facility
Amersfoort, 3818 TZ, Netherlands
Unknown Facility
Amsterdam, 1091 AC, Netherlands
Unknown Facility
Amsterdam, 1105 AZ, Netherlands
Unknown Facility
Apeldoorn, 7334 DZ, Netherlands
Unknown Facility
Breda, 4818 CK, Netherlands
Unknown Facility
Dordrecht, 3318 AT, Netherlands
Unknown Facility
Eindhoven, 5600 PD, Netherlands
Unknown Facility
Geleen, 6162 BG, Netherlands
Unknown Facility
Groningen, 9713 GZ, Netherlands
Unknown Facility
Hoogeveen, 7909 AA, Netherlands
Unknown Facility
Nieuwegein, 3435 CM, Netherlands
Unknown Facility
The Hague, 2545 CH, Netherlands
Unknown Facility
Zwijndrecht, 3331 LZ, Netherlands
Unknown Facility
Auckland, 2025, New Zealand
Unknown Facility
Auckland, New Zealand
Unknown Facility
Christchurch, 8011, New Zealand
Unknown Facility
Hamilton, 3204, New Zealand
Unknown Facility
Hawkes Bay, 4130, New Zealand
Unknown Facility
Palmerston North, 4414, New Zealand
Unknown Facility
Tauranga, 3110, New Zealand
Unknown Facility
Wellington, New Zealand
Unknown Facility
Ålesund, Norway
Unknown Facility
Hamar, 2317, Norway
Unknown Facility
Hamar, Norway
Unknown Facility
Kløfta, 2040, Norway
Unknown Facility
Kristiansand, 4604, Norway
Unknown Facility
Levanger, 7601, Norway
Unknown Facility
Oslo, 0176, Norway
Unknown Facility
Oslo, 0450, Norway
Unknown Facility
Skedsmokorset, 2020, Norway
Unknown Facility
Trondheim, 7030, Norway
Unknown Facility
Iloilo City, 5000, Philippines
Unknown Facility
Marikina City, Philippines
Unknown Facility
Pasig, 1600, Philippines
Unknown Facility
Quezon City, 1102, Philippines
Unknown Facility
Quezon City, 1110, Philippines
Unknown Facility
Quezon City, 1112, Philippines
Unknown Facility
Bialystok, 15-351, Poland
Unknown Facility
Bydgoszcz, 85-079, Poland
Unknown Facility
Chojnice, 89-600, Poland
Unknown Facility
Gdansk, 80-214, Poland
Unknown Facility
Gdynia, 81-537, Poland
Unknown Facility
Katowice, 40-040, Poland
Unknown Facility
Krakow, 30-510, Poland
Unknown Facility
Krakow, 31-156, Poland
Unknown Facility
Krakow, 31-261, Poland
Unknown Facility
Krakow, 31-559, Poland
Unknown Facility
Lodz, 90-153, Poland
Unknown Facility
Lodz, 92-213, Poland
Unknown Facility
Lodz, 94-060, Poland
Unknown Facility
Lublin, 20-538, Poland
Unknown Facility
Olsztyn, 10-561, Poland
Unknown Facility
Poznan, 60-834, Poland
Unknown Facility
Rzeszów, 35-055, Poland
Unknown Facility
Skorzewo, 60-185, Poland
Unknown Facility
Szczecin, 70-111, Poland
Unknown Facility
Torun, 87-100, Poland
Unknown Facility
Warsaw, 01-868, Poland
Unknown Facility
Warsaw, Poland
Unknown Facility
Wroclaw, 51-162, Poland
Unknown Facility
Wroclaw, 51-685, Poland
Unknown Facility
Zabrze, 41-800, Poland
Unknown Facility
Covilha, Castelo Branco District, 6200-251, Portugal
Unknown Facility
Loures, Lisbon District, 2674-514, Portugal
Unknown Facility
Funchal, Madeira, 9004-514, Portugal
Unknown Facility
Matosinhos Municipality, Porto District, 4464-513, Portugal
Unknown Facility
Torres Novas, Santarém District, 2350-754, Portugal
Unknown Facility
Setúbal, Setúbal District, 2900-446, Portugal
Unknown Facility
Almada, 2801-951, Portugal
Unknown Facility
Amadora, 2720-276, Portugal
Unknown Facility
Braga, 4710-243, Portugal
Unknown Facility
Faro, 8000-386, Portugal
Unknown Facility
Leiria, 2410-197, Portugal
Unknown Facility
Lisbon, 1069-166, Portugal
Unknown Facility
Lisbon, 1250-189, Portugal
Unknown Facility
Lisbon, 1449-005, Portugal
Unknown Facility
Lisbon, 1500-650, Portugal
Unknown Facility
Porto, 4099-001, Portugal
Unknown Facility
Porto, 4200-319, Portugal
Unknown Facility
Viana do Castelo, 4901-858, Portugal
Unknown Facility
Cidra, 00739, Puerto Rico
Unknown Facility
San Juan, 00909-3004, Puerto Rico
Unknown Facility
Alba Iulia, Alba, 510053, Romania
Unknown Facility
Baia Mare, Maramureş, 430222, Romania
Unknown Facility
Ploieşti, Prahova, 100179, Romania
Unknown Facility
Timișoara, Timiș County, 300456, Romania
Unknown Facility
Bucharest, 010507, Romania
Unknown Facility
Bucharest, 010627, Romania
Unknown Facility
Bucharest, 010825, Romania
Unknown Facility
Bucharest, 014142, Romania
Unknown Facility
Bucharest, 020614, Romania
Unknown Facility
Bucharest, 031818, Romania
Unknown Facility
Bucharest, 050538, Romania
Unknown Facility
Cluj-Napoca, 400006, Romania
Unknown Facility
Galati, 800001, Romania
Unknown Facility
Iași, 700547, Romania
Unknown Facility
Oradea, 410159, Romania
Unknown Facility
Satu Mare, 440192, Romania
Unknown Facility
Timișoara, 300736, Romania
Unknown Facility
Arkhangelsk, 163001, Russia
Unknown Facility
Barnaul, 656024, Russia
Unknown Facility
Chelyabinsk, 454021, Russia
Unknown Facility
Irkutsk, 664079, Russia
Unknown Facility
Izhevsk, 426063, Russia
Unknown Facility
Kazan', 420012, Russia
Unknown Facility
Kazan', 420101, Russia
Unknown Facility
Kemerovo, 650002, Russia
Unknown Facility
Kemerovo, 650055, Russia
Unknown Facility
Kemerovo, 650066, Russia
Unknown Facility
Kirov, 610014, Russia
Unknown Facility
Krasnodar, 350086, Russia
Unknown Facility
Krasnoyarsk, 660062, Russia
Unknown Facility
Kursk, 305004, Russia
Unknown Facility
Moscow, 111539, Russia
Unknown Facility
Moscow, 117292, Russia
Unknown Facility
Moscow, 119034, Russia
Unknown Facility
Moscow, 119991, Russia
Unknown Facility
Moscow, 123182, Russia
Unknown Facility
Moscow, 123423, Russia
Unknown Facility
Moscow, 125101, Russia
Unknown Facility
Moscow, 125315, Russia
Unknown Facility
Moscow, 129110, Russia
Unknown Facility
Nizhny Novgorod, 603018, Russia
Unknown Facility
Nizhny Novgorod, 603126, Russia
Unknown Facility
Novosibirsk, 630005, Russia
Unknown Facility
Novosibirsk, 630047, Russia
Unknown Facility
Novosibirsk, 630089, Russia
Unknown Facility
Novosibirsk, 630117, Russia
Unknown Facility
Omsk, 644024, Russia
Unknown Facility
Omsk, 644033, Russia
Unknown Facility
Omsk, 644112, Russia
Unknown Facility
Orenburg, 460040, Russia
Unknown Facility
Perm, 614097, Russia
Unknown Facility
Ryazan, 390026, Russia
Unknown Facility
Saint Petersburg, 193312, Russia
Unknown Facility
Saint Petersburg, 194044, Russia
Unknown Facility
Saint Petersburg, 194223, Russia
Unknown Facility
Saint Petersburg, 194354, Russia
Unknown Facility
Saint Petersburg, 195067, Russia
Unknown Facility
Saint Petersburg, 195112, Russia
Unknown Facility
Saint Petersburg, 195257, Russia
Unknown Facility
Saint Petersburg, 197762, Russia
Unknown Facility
Saint Petersburg, 199226, Russia
Unknown Facility
Saratov, 410030, Russia
Unknown Facility
Stavropol, 355030, Russia
Unknown Facility
Syktyvkar, 167981, Russia
Unknown Facility
Voronezh, 394018, Russia
Unknown Facility
Voronezh, 394077, Russia
Unknown Facility
Yaroslavl, 150003, Russia
Unknown Facility
Yaroslavl, 150062, Russia
Unknown Facility
Yekaterinburg, 620102, Russia
Unknown Facility
Singapore, 119074, Singapore
Unknown Facility
Singapore, 169608, Singapore
Unknown Facility
Singapore, 169609, Singapore
Unknown Facility
Singapore, 529889, Singapore
Unknown Facility
Singapore, 768828, Singapore
Unknown Facility
Bardejov, 085 01, Slovakia
Unknown Facility
Nitra, 949 11, Slovakia
Unknown Facility
Rimavská Sobota, 979 01, Slovakia
Unknown Facility
Rožňava, 048 01, Slovakia
Unknown Facility
Žilina, 01001, Slovakia
Unknown Facility
Port Elizabeth, Eastern Cape, 6045, South Africa
Unknown Facility
Benoni, Gauteng, 1501, South Africa
Unknown Facility
Johannesburg, Gauteng, 2198, South Africa
Unknown Facility
Lenasia South, Gauteng, 1835, South Africa
Unknown Facility
Newtown, Gauteng, 2113, South Africa
Unknown Facility
Petoria, Gauteng, South Africa
Unknown Facility
Pretoria, Gauteng, 0002, South Africa
Unknown Facility
Pretoria, Gauteng, 0181, South Africa
Unknown Facility
Soweto, Gauteng, 1818, South Africa
Unknown Facility
Durban, KwaZulu-Natal, 4030, South Africa
Unknown Facility
Isipingo Rail, KwaZulu-Natal, 4110, South Africa
Unknown Facility
Tongaat, KwaZulu-Natal, 4400, South Africa
Unknown Facility
Middelburg, Mpumalanga, 1055, South Africa
Unknown Facility
Witbank, Mpumalanga, 1035, South Africa
Unknown Facility
Cape Town, Western Cape, 7570, South Africa
Unknown Facility
Cape Town, Western Cape, 7925, South Africa
Unknown Facility
Somerset West, Western Cape, 7130, South Africa
Unknown Facility
Worcester, Western Cape, 6850, South Africa
Unknown Facility
Pretoria, 0002, South Africa
Unknown Facility
Chuncheon, Gang''weondo, 0, South Korea
Unknown Facility
Wŏnju, Gang''weondo, 26426, South Korea
Unknown Facility
Anyang-si, Gyeonggido, 14068, South Korea
Unknown Facility
Goyang-si, Gyeonggido, 10475, South Korea
Unknown Facility
Incheon Gwangyeogsi,, Incheon Gwang''yeogsi, 21431, South Korea
Unknown Facility
Seoul, Seoul Teugbyeolsi, 03080, South Korea
Unknown Facility
Seoul, Seoul Teugbyeolsi, 17985, South Korea
Unknown Facility
Busan, 47392, South Korea
Unknown Facility
Busan, 49241, South Korea
Unknown Facility
Daejeon, 35015, South Korea
Unknown Facility
Seoul, 01830, South Korea
Unknown Facility
Seoul, 02841, South Korea
Unknown Facility
Seoul, 03722, South Korea
Unknown Facility
Seoul, 05278, South Korea
Unknown Facility
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Ferrol, A Coruña, 15405, Spain
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Badalona, Barcelona, 08916, Spain
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Manresa, Barcelona, 08243, Spain
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Sant Joan Despí, Barcelona, 08970, Spain
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Jerez de la Frontera, Cádiz, 11407, Spain
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Burela de Cabo, Lugo, 27880, Spain
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Alcalá de Henares, Madrid, 28805, Spain
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Boadilla del Monte, Madrid, 28660, Spain
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Gothenburg, 413 45, Sweden
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Liestal, Basel-Landschaft, 4410, Switzerland
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Bern, 3010, Switzerland
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Taoyuan District, 33305, Taiwan
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Ankara, Turkey (Türkiye)
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Edirne, 22030, Turkey (Türkiye)
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Izmir, 35540, Turkey (Türkiye)
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Kayseri, 38039, Turkey (Türkiye)
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Kocaeli, 41380, Turkey (Türkiye)
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Malatya, 44280, Turkey (Türkiye)
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Sivas, 58140, Turkey (Türkiye)
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Cherkasy, 18009, Ukraine
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Lviv, 79010, Ukraine
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Mykolayiv, 54003, Ukraine
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Ternopil, 46002, Ukraine
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Uzhhorod, 88018, Ukraine
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Vinnytsia, 21001, Ukraine
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Zaporizhzhya, 69001, Ukraine
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Llanelli, Carmarthenshire, SA14 8QF, United Kingdom
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Leicester, Leicestershire, LE5 4PW, United Kingdom
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Salford, Manchester, M6 8HD, United Kingdom
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Carshalton, Surrey, SM5 1AA, United Kingdom
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Newcastle upon Tyne, Vale of Glamorgan, the, NE1 4LP, United Kingdom
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Chichester, West Sussex, PO19 6SE, United Kingdom
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Bristol, BS10 5NB, United Kingdom
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London, E1 1BB, United Kingdom
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London, NW3 2QG, United Kingdom
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London, SE5 9RS, United Kingdom
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Manchester, M8 5RB, United Kingdom
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Middlesbrough, TS4 3BW, United Kingdom
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Portsmouth, PO6 3LY, United Kingdom
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Hà Nội, 10000, Vietnam
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Hà Nội, Vietnam
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Ho Chi Minh City, 70000, Vietnam
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Ho Chi Minh City, 84, Vietnam
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Ho Chi Minh City, Vietnam
Related Publications (28)
Bakris GL, Agarwal R, Anker SD, Pitt B, Ruilope LM, Nowack C, Kolkhof P, Ferreira AC, Schloemer P, Filippatos G; on behalf of the FIDELIO-DKD study investigators; FIDELIO-DKD study investigators. Design and Baseline Characteristics of the Finerenone in Reducing Kidney Failure and Disease Progression in Diabetic Kidney Disease Trial. Am J Nephrol. 2019;50(5):333-344. doi: 10.1159/000503713. Epub 2019 Oct 25.
PMID: 31655812BACKGROUNDBakris GL, Agarwal R, Anker SD, Pitt B, Ruilope LM, Rossing P, Kolkhof P, Nowack C, Schloemer P, Joseph A, Filippatos G; FIDELIO-DKD Investigators. Effect of Finerenone on Chronic Kidney Disease Outcomes in Type 2 Diabetes. N Engl J Med. 2020 Dec 3;383(23):2219-2229. doi: 10.1056/NEJMoa2025845. Epub 2020 Oct 23.
PMID: 33264825RESULTFilippatos G, Anker SD, Agarwal R, Pitt B, Ruilope LM, Rossing P, Kolkhof P, Schloemer P, Tornus I, Joseph A, Bakris GL; FIDELIO-DKD Investigators. Finerenone and Cardiovascular Outcomes in Patients With Chronic Kidney Disease and Type 2 Diabetes. Circulation. 2021 Feb 9;143(6):540-552. doi: 10.1161/CIRCULATIONAHA.120.051898. Epub 2020 Nov 16.
PMID: 33198491RESULTKatayama S, Anker SD, Zhu D, Kim S, Wu MJ, Kawanami D, Rossing P, Ruilope LM, Ahlers C, Brinker M, Mann A, Tian Y, Yamashita S, Pitt B; FIDELIO-DKD and FIGARO-DKD Investigators. Efficacy and safety of finerenone in Asian patients with type 2 diabetes and chronic kidney disease: A FIDELITY analysis by baseline kidney function. J Diabetes Complications. 2026 Jan;40(1):109213. doi: 10.1016/j.jdiacomp.2025.109213. Epub 2025 Nov 4.
PMID: 41289823DERIVEDMottl A, Scott C, Green JB, Heerspink HJL, Mann JFE, McGill JB, Nangaku M, Rosenstock J, Rossing P, Li L, Li N, Vaduganathan M, Agarwal R; CONFIDENCE Trial Investigators. Baseline Kidney Function, Albuminuria, and Urine Albumin-Creatinine Ratio Reduction with Finerenone, Empagliflozin, or Both: Post Hoc Analyses of CONFIDENCE Trial. J Am Soc Nephrol. 2025 Nov 6. doi: 10.1681/ASN.0000000928. Online ahead of print. No abstract available.
PMID: 41196655DERIVEDFerreira JP, Mendonca L, Marques P, Neves JS, Zannad F, Packer M. Albuminuria Is the Key Driver of Kidney Benefit with Aldosterone Receptor Antagonists in Type 2 Diabetes. J Am Soc Nephrol. 2025 Sep 2. doi: 10.1681/ASN.0000000877. Online ahead of print. No abstract available.
PMID: 40892478DERIVEDJongs N, Gasparyan SB, Frison L, Schloemer P, Brinker M, Little DJ, Heerspink HJL. Use of eGFR Slope Thresholds as End Point Components in a Kidney Disease Progression Hierarchical Composite End Point. J Am Soc Nephrol. 2025 Dec 1;36(12):2421-2430. doi: 10.1681/ASN.0000000766. Epub 2025 Jun 17.
PMID: 40526444DERIVEDRossing P, Birkenfeld AL, Fioretto P, McGill JB, Anker SD, Pitt B, Rohwedder K, Scalise A, Scott C, Filippatos G; FIDELIO-DKD and FIGARO-DKD Investigators. Finerenone and Clinical Outcomes in CKD and Type 2 Diabetes by Frailty Index: FIDELITY Post Hoc Analysis. Clin J Am Soc Nephrol. 2025 May 2;20(7):968-977. doi: 10.2215/CJN.0000000700.
PMID: 40315020DERIVEDPitt B, Agarwal R, Anker SD, Rossing P, Ruilope L, Herzog CA, Greenberg B, Pecoits-Filho R, Lambelet M, Lawatscheck R, Scalise A, Filippatos G. Hypokalaemia in patients with type 2 diabetes and chronic kidney disease: the effect of finerenone-a FIDELITY analysis. Eur Heart J Cardiovasc Pharmacother. 2025 Feb 8;11(1):10-19. doi: 10.1093/ehjcvp/pvae074.
PMID: 39380152DERIVEDBansal S, Canziani MEF, Birne R, Anker SD, Bakris GL, Filippatos G, Rossing P, Ruilope LM, Farjat AE, Kolkhof P, Lage A, Brinker M, Pitt B. Finerenone cardiovascular and kidney outcomes by age and sex: FIDELITY post hoc analysis of two phase 3, multicentre, double-blind trials. BMJ Open. 2024 Mar 19;14(3):e076444. doi: 10.1136/bmjopen-2023-076444.
PMID: 38508632DERIVEDAgarwal R, Tu W, Farjat AE, Farag YMK, Toto R, Kaul S, Lawatscheck R, Rohwedder K, Ruilope LM, Rossing P, Pitt B, Filippatos G, Anker SD, Bakris GL; FIDELIO-DKD and FIGARO-DKD Investigators. Impact of Finerenone-Induced Albuminuria Reduction on Chronic Kidney Disease Outcomes in Type 2 Diabetes : A Mediation Analysis. Ann Intern Med. 2023 Dec;176(12):1606-1616. doi: 10.7326/M23-1023. Epub 2023 Dec 5.
PMID: 38048573DERIVEDFlack JM, Agarwal R, Anker SD, Pitt B, Ruilope LM, Rossing P, Adler SG, Fried L, Jamerson K, Toto R, Brinker M, Farjat AE, Kolkhof P, Lawatscheck R, Joseph A, Bakris GL; FIDELIO-DKD and FIGARO-DKD Investigators. Finerenone in Black Patients With Type 2 Diabetes and CKD: A Post hoc Analysis of the Pooled FIDELIO-DKD and FIGARO-DKD Trials. Kidney Med. 2023 Sep 28;5(12):100730. doi: 10.1016/j.xkme.2023.100730. eCollection 2023 Dec.
PMID: 38046911DERIVEDHeerspink HJL, Jongs N, Schloemer P, Little DJ, Brinker M, Tasto C, Karpefors M, Wheeler DC, Bakris G, Perkovic V, Nkulikiyinka R, Rossert J, Gasparyan SB. Development and Validation of a New Hierarchical Composite End Point for Clinical Trials of Kidney Disease Progression. J Am Soc Nephrol. 2023 Dec 1;34(12):2025-2038. doi: 10.1681/ASN.0000000000000243. Epub 2023 Oct 24.
PMID: 37872654DERIVEDRosas SE, Ruilope LM, Anker SD, Pitt B, Rossing P, Bonfanti AAC, Correa-Rotter R, Gonzalez F, Munoz CFJ, Pergola P, Umpierrez GE, Scalise A, Scott C, Lawatscheck R, Joseph A, Bakris GL; FIDELIO-DKD and FIGARO-DKD investigators. Finerenone in Hispanic Patients With CKD and Type 2 Diabetes: A Post Hoc FIDELITY Analysis. Kidney Med. 2023 Aug 1;5(10):100704. doi: 10.1016/j.xkme.2023.100704. eCollection 2023 Oct.
PMID: 37745646DERIVEDSarafidis P, Agarwal R, Pitt B, Wanner C, Filippatos G, Boletis J, Tuttle KR, Ruilope LM, Rossing P, Toto R, Anker SD, Liu ZH, Joseph A, Ahlers C, Brinker M, Lawatscheck R, Bakris G; FIDELIO-DKD and FIGARO-DKD Investigators. Outcomes with Finerenone in Participants with Stage 4 CKD and Type 2 Diabetes: A FIDELITY Subgroup Analysis. Clin J Am Soc Nephrol. 2023 May 1;18(5):602-612. doi: 10.2215/CJN.0000000000000149. Epub 2023 Apr 7.
PMID: 36927680DERIVEDAgarwal R, Pitt B, Palmer BF, Kovesdy CP, Burgess E, Filippatos G, Malyszko J, Ruilope LM, Rossignol P, Rossing P, Pecoits-Filho R, Anker SD, Joseph A, Lawatscheck R, Wilson D, Gebel M, Bakris GL. A comparative post hoc analysis of finerenone and spironolactone in resistant hypertension in moderate-to-advanced chronic kidney disease. Clin Kidney J. 2022 Oct 30;16(2):293-302. doi: 10.1093/ckj/sfac234. eCollection 2023 Feb.
PMID: 36864892DERIVEDFilippatos G, Anker SD, August P, Coats AJS, Januzzi JL, Mankovsky B, Rossing P, Ruilope LM, Pitt B, Sarafidis P, Teerlink JR, Kapelios CJ, Gebel M, Brinker M, Joseph A, Lage A, Bakris G, Agarwal R. Finerenone and effects on mortality in chronic kidney disease and type 2 diabetes: a FIDELITY analysis. Eur Heart J Cardiovasc Pharmacother. 2023 Feb 2;9(2):183-191. doi: 10.1093/ehjcvp/pvad001.
PMID: 36639130DERIVEDFilippatos G, Anker SD, Pitt B, Rossing P, Joseph A, Kolkhof P, Lambelet M, Lawatscheck R, Bakris GL, Ruilope LM, Agarwal R. Finerenone and Heart Failure Outcomes by Kidney Function/Albuminuria in Chronic Kidney Disease and Diabetes. JACC Heart Fail. 2022 Nov;10(11):860-870. doi: 10.1016/j.jchf.2022.07.013. Epub 2022 Oct 12.
PMID: 36328655DERIVEDPitt B, Agarwal R, Anker SD, Ruilope LM, Rossing P, Ahlers C, Brinker M, Joseph A, Lambelet M, Lawatscheck R, Filippatos GS; FIDELIO-DKD and FIGARO-DKD Investigators. Association of Finerenone Use With Reduction in Treatment-Emergent Pneumonia and COVID-19 Adverse Events Among Patients With Type 2 Diabetes and Chronic Kidney Disease: A FIDELITY Pooled Secondary Analysis. JAMA Netw Open. 2022 Oct 3;5(10):e2236123. doi: 10.1001/jamanetworkopen.2022.36123.
PMID: 36287567DERIVEDRuilope LM, Agarwal R, Anker SD, Filippatos G, Pitt B, Rossing P, Sarafidis P, Schmieder RE, Joseph A, Rethemeier N, Nowack C, Bakris GL; FIDELIO-DKD Investigators. Blood Pressure and Cardiorenal Outcomes With Finerenone in Chronic Kidney Disease in Type 2 Diabetes. Hypertension. 2022 Dec;79(12):2685-2695. doi: 10.1161/HYPERTENSIONAHA.122.19744. Epub 2022 Oct 12.
PMID: 36252131DERIVEDFilippatos G, Anker SD, Pitt B, McGuire DK, Rossing P, Ruilope LM, Butler J, Jankowska EA, Michos ED, Farmakis D, Farjat AE, Kolkhof P, Scalise A, Joseph A, Bakris GL, Agarwal R. Finerenone efficacy in patients with chronic kidney disease, type 2 diabetes and atherosclerotic cardiovascular disease. Eur Heart J Cardiovasc Pharmacother. 2022 Dec 15;9(1):85-93. doi: 10.1093/ehjcvp/pvac054.
PMID: 36251465DERIVEDRossing P, Burgess E, Agarwal R, Anker SD, Filippatos G, Pitt B, Ruilope LM, Gillard P, MacIsaac RJ, Wainstein J, Joseph A, Brinker M, Roessig L, Scott C, Bakris GL; FIDELIO-DKD Investigators. Finerenone in Patients With Chronic Kidney Disease and Type 2 Diabetes According to Baseline HbA1c and Insulin Use: An Analysis From the FIDELIO-DKD Study. Diabetes Care. 2022 Apr 1;45(4):888-897. doi: 10.2337/dc21-1944.
PMID: 35061867DERIVEDRossing P, Filippatos G, Agarwal R, Anker SD, Pitt B, Ruilope LM, Chan JCN, Kooy A, McCafferty K, Schernthaner G, Wanner C, Joseph A, Scheerer MF, Scott C, Bakris GL; FIDELIO-DKD Investigators. Finerenone in Predominantly Advanced CKD and Type 2 Diabetes With or Without Sodium-Glucose Cotransporter-2 Inhibitor Therapy. Kidney Int Rep. 2021 Oct 14;7(1):36-45. doi: 10.1016/j.ekir.2021.10.008. eCollection 2022 Jan.
PMID: 35005312DERIVEDAgarwal R, Anker SD, Filippatos G, Pitt B, Rossing P, Ruilope LM, Boletis J, Toto R, Umpierrez GE, Wanner C, Wada T, Scott C, Joseph A, Ogbaa I, Roberts L, Scheerer MF, Bakris GL. Effects of canagliflozin versus finerenone on cardiorenal outcomes: exploratory post hoc analyses from FIDELIO-DKD compared to reported CREDENCE results. Nephrol Dial Transplant. 2022 Jun 23;37(7):1261-1269. doi: 10.1093/ndt/gfab336.
PMID: 34850173DERIVEDFilippatos G, Bakris GL, Pitt B, Agarwal R, Rossing P, Ruilope LM, Butler J, Lam CSP, Kolkhof P, Roberts L, Tasto C, Joseph A, Anker SD; FIDELIO-DKD Investigators. Finerenone Reduces New-Onset Atrial Fibrillation in Patients With Chronic Kidney Disease and Type 2 Diabetes. J Am Coll Cardiol. 2021 Jul 13;78(2):142-152. doi: 10.1016/j.jacc.2021.04.079. Epub 2021 May 17.
PMID: 34015478DERIVEDErraez S, Lopez-Mesa M, Gomez-Fernandez P. Mineralcorticoid receptor blockers in chronic kidney disease. Nefrologia (Engl Ed). 2021 May-Jun;41(3):258-275. doi: 10.1016/j.nefro.2020.10.001. Epub 2020 Dec 24. English, Spanish.
PMID: 33358451DERIVEDAgarwal R, Anker SD, Bakris G, Filippatos G, Pitt B, Rossing P, Ruilope L, Gebel M, Kolkhof P, Nowack C, Joseph A; FIDELIO-DKD and FIGARO-DKD Investigators. Investigating new treatment opportunities for patients with chronic kidney disease in type 2 diabetes: the role of finerenone. Nephrol Dial Transplant. 2022 May 25;37(6):1014-1023. doi: 10.1093/ndt/gfaa294.
PMID: 33280027DERIVEDChung EY, Ruospo M, Natale P, Bolignano D, Navaneethan SD, Palmer SC, Strippoli GF. Aldosterone antagonists in addition to renin angiotensin system antagonists for preventing the progression of chronic kidney disease. Cochrane Database Syst Rev. 2020 Oct 27;10(10):CD007004. doi: 10.1002/14651858.CD007004.pub4.
PMID: 33107592DERIVED
Related Links
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Results Point of Contact
- Title
- Therapeutic Area Head
- Organization
- Bayer
Study Officials
- STUDY DIRECTOR
Bayer Study Director
Bayer
Publication Agreements
- PI is Sponsor Employee
- No
- Restriction Type
- OTHER
- Restrictive Agreement
- Yes
Study Design
- Study Type
- interventional
- Phase
- phase 3
- Allocation
- RANDOMIZED
- Masking
- QUADRUPLE
- Who Masked
- PARTICIPANT, CARE PROVIDER, INVESTIGATOR, OUTCOMES ASSESSOR
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- INDUSTRY
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
September 2, 2015
First Posted
September 4, 2015
Study Start
September 17, 2015
Primary Completion
April 14, 2020
Study Completion
April 14, 2020
Last Updated
July 24, 2023
Results First Posted
July 19, 2021
Record last verified: 2023-07