NCT05038033

Brief Summary

Project ASSET will explore the preliminary efficacy of interpersonal therapy, when compared with cognitive behavioral therapy, for reducing anxiety symptoms, preventing excess weight gain, and reducing cardio-metabolic risk in adolescent girls with above-average weight and elevated anxiety. As a pilot for a larger multi-site study, this trial will also test multi-site feasibility, acceptability, and intervention fidelity.

Trial Health

43
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
40

participants targeted

Target at P25-P50 for not_applicable obesity

Timeline
Completed

Started Feb 2021

Typical duration for not_applicable obesity

Geographic Reach
1 country

2 active sites

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Start

First participant enrolled

February 22, 2021

Completed
6 months until next milestone

First Submitted

Initial submission to the registry

August 31, 2021

Completed
8 days until next milestone

First Posted

Study publicly available on registry

September 8, 2021

Completed
2.6 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

May 1, 2024

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

May 1, 2024

Completed
Last Updated

September 8, 2021

Status Verified

August 1, 2021

Enrollment Period

3.2 years

First QC Date

August 31, 2021

Last Update Submit

August 31, 2021

Conditions

Keywords

ObesityOverweightAnxietyAdolescentPreventionInterpersonal PsychotherapyCognitive Behavioral Therapy

Outcome Measures

Primary Outcomes (1)

  • Intervention Fidelity and Acceptability

    Feasibility: Fidelity ratings of facilitators' competence/adherence in administration of IPT and CBT; CONSORT tracking of recruitment, recruitment rate and percentage of eligible adolescents who enroll as recorded by study coordinators; median sessions attended and home practice completion, as recorded by facilitators; CONSORT tracking of follow-up retention as recorded by study coordinators; and completeness of data collection. Acceptability: Adolescent self-reports on program and monitor acceptability questionnaires

    Entirety of the Study

Secondary Outcomes (8)

  • Presence of Disinhibited Eating

    Post-Treatment

  • Mood/Anxiety, Eating, And Social Functioning

    Post Treatment

  • Participant Height, Weight, and Blood Pressure

    Post Treatment

  • Body Composition Measurement

    Post treatment

  • Collection of Metabolic Markers

    Post Treatment

  • +3 more secondary outcomes

Study Arms (2)

Interpersonal Psychotherapy (IPT)

EXPERIMENTAL

Interpersonal Psychotherapy program adapted for the prevention of excessive weight gain. Involves one initial 1.5-hour individual session, and 12 weekly 90-minute group sessions.

Behavioral: Interpersonal Psychotherapy (IPT)

Cognitive-Behavioral Therapy (CBT)

ACTIVE COMPARATOR

The CBT program will match the delivery format and dose of the IPT program. There will be one initial 1.5-hour individual session, and 12 weekly 90-minute group sessions.

Behavioral: Cognitive Behavioral Theory (CBT)

Interventions

The IPT group sessions follow three phases (initial, middle, and termination) and use the interpersonal inventory to identify interpersonal problems that might be contributing to or exacerbating disinhibited eating and anxiety symptoms. A framework of common problem areas is used to teach interpersonal problem-solving and communication skills and educate youth about risk factors and warning signs for excessive weight gain, such as eating in response to negative affect as opposed to hunger, or feeling a sense of loss-of-control while eating. IPT focuses on psychoeducation and general skill-building that can be applied to different relationships within the framework of four interpersonal problem areas: interpersonal role disputes, role transitions, interpersonal deficits, and grief.

Interpersonal Psychotherapy (IPT)

The CBT program will be derived from Coping Cat, a manualized intervention for children and adolescents with elevated symptoms of anxiety. The group intervention builds skills for managing anxiety, in general, but with a focus on how anxiety prompts disinhibited eating, including attention to and restructuring of negative cognitions that perpetuate anxiety and behavioral exposure, rather than avoidance, of anxiety-provoking situations.

Cognitive-Behavioral Therapy (CBT)

Eligibility Criteria

Age12 Years - 17 Years
Sexfemale
Healthy VolunteersYes
Age GroupsChild (0-17)

You may qualify if:

  • year-old adolescent girls
  • BMI ≥ 75th percentile
  • Anxiety symptoms: 32 or higher on State Trait Anxiety Inventory for Children-Trait Scale

You may not qualify if:

  • Any medical condition (as well as pregnancy or breastfeeding)
  • Individuals who have any DSM psychiatric disorder that, in the opinion of the investigators, would impede competence or compliance or possibly hinder completion of the study
  • Medication impacting mood or weight
  • Psychotherapy

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (2)

Colorado State University

Fort Collins, Colorado, 80523-1570, United States

RECRUITING

Uniformed Services University

Bethesda, Maryland, 20814, United States

RECRUITING

MeSH Terms

Conditions

ObesityOverweightAnxiety DisordersMental DisordersBody WeightFeeding BehaviorFeeding and Eating Disorders

Interventions

Interpersonal Psychotherapy

Condition Hierarchy (Ancestors)

OvernutritionNutrition DisordersNutritional and Metabolic DiseasesSigns and SymptomsPathological Conditions, Signs and SymptomsBehavior, AnimalBehaviorSigns and Symptoms, Digestive

Intervention Hierarchy (Ancestors)

PsychotherapyBehavioral Disciplines and Activities

Central Study Contacts

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
NONE
Purpose
PREVENTION
Intervention Model
PARALLEL
Model Details: Randomized controlled trial with two treatment arms and two intervention cohorts across two sites.
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

August 31, 2021

First Posted

September 8, 2021

Study Start

February 22, 2021

Primary Completion

May 1, 2024

Study Completion

May 1, 2024

Last Updated

September 8, 2021

Record last verified: 2021-08

Locations