Relationship Between the Clinical Pharmacist & Antibiotic Use by Using the Electronic Program

NCT05002647 | Completed DMC

• 1 other identifier: 14-2021/13
• Study Type: observational
• Target: 2,601
• Locations: 1 country
• Sites: 1

Brief Summary

A retrospective cohort study to explore the association between clinical pharmacists' interventions and antibiotic consumption through the use of the medical electronic reports and to identify mortality and cost savings in hospital infectious disease.

Conditions

Clinical Pharmacists; Electronic Medical Record

Keywords

clinical pharmacist; antibiotic consumption; antibiotic use; cost-saving

Outcome Measures

Primary Outcomes (3)

• Antimicrobial consumption

  consumption of antimicrobials (defined daily doses / 100 patient-days)

  2 years

• Days of therapy (DOT)

  Number of days of each antimicrobial received for therapy

  2 years

• Length of therapy(LOT)

  The number of days a patient takes an antibacterial drug, regardless of the number of different medications

  2 years

Secondary Outcomes (4)

• cost savings

  2 years

• Mortality rate

  2 years

• Antimicrobial resistance

  2 years

• The incidence of adverse reaction of antimicrobial

  2 years

Study Arms (3)

exposure group

Data from electronic clinical pharmacist records of two infectious disease hospitals

Other: NO intervention

Non-exposure group A

Data from medical records of the hospital with no clinical pharmacy.

Other: NO intervention

Non-exposure group B

Data from a medical record of the hospital with clinical pharmacy, but the department did not cover by the clinical pharmacy

Other: NO intervention

Interventions

NO intervention OTHER

There is no intervention

Non-exposure group A; Non-exposure group B; exposure group

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

All patients who administered antimicrobials

You may qualify if:

• All inpatient with infectious disease (disorders caused by organisms as (bacteria, viruses, fungi, or parasites).

You may not qualify if:

• Any other cause of hospital admission other than infectious disease.

Sponsors & Collaborators

• Alexandria University: lead
• Ministry of Health and Population, Egypt: collaborator

Study Sites (1)

Ministers of health

Alexandria, 22511, Egypt

Location

Related Publications (3)

• Karakonstantis S, Kalemaki D. Antimicrobial overuse and misuse in the community in Greece and link to antimicrobial resistance using methicillin-resistant S. aureus as an example. J Infect Public Health. 2019 Jul-Aug;12(4):460-464. doi: 10.1016/j.jiph.2019.03.017. Epub 2019 Apr 10.

  PMID: 30981652 BACKGROUND

• Dyar OJ, Huttner B, Schouten J, Pulcini C; ESGAP (ESCMID Study Group for Antimicrobial stewardshiP). What is antimicrobial stewardship? Clin Microbiol Infect. 2017 Nov;23(11):793-798. doi: 10.1016/j.cmi.2017.08.026. Epub 2017 Sep 4.

  PMID: 28882725 BACKGROUND

• Ourghanlian C, Lapidus N, Antignac M, Fernandez C, Dumartin C, Hindlet P. Pharmacists' role in antimicrobial stewardship and relationship with antibiotic consumption in hospitals: An observational multicentre study. J Glob Antimicrob Resist. 2020 Mar;20:131-134. doi: 10.1016/j.jgar.2019.07.009. Epub 2019 Jul 16.

  PMID: 31323427 BACKGROUND

Study Officials

• Amira zidane

  Ministry of Health and Population, Egypt

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: August 7, 2021
• First Posted: August 12, 2021
• Study Start: September 15, 2021
• Primary Completion: January 1, 2022
• Study Completion: March 10, 2022
• Last Updated: December 27, 2024

Record last verified: 2021-08

Locations

EG (1)