Resistance-type Exercise Training in the Older Population

NCT04999501 | Completed DMC

• 1 other identifier: FONDECYT 11180949
• Study Type: interventional
• Target: 31
• Locations: 1 country
• Sites: 1

Brief Summary

Background: Aging is associated with muscle mass and strength loss and "oldest" old people (≥85 y) are at a far greater risk of developing sarcopenia. Training increases muscle mass and strength in a variety of populations, yet the efficacy has not been clearly defined for individuals in the fourth age (≥80 y). Hypothesis: The following hypotheses will be investigated:

• Twelve weeks of progressive resistance-type exercise training increases muscle mass and strength in young old (65-75 y) and oldest old (85 y and over) subjects.
• The training-induced increase in muscle mass and strength is relatively greater in young old subjects when compared to oldest old subjects. Goals: The primary aim of this study is to compare the effect of resistance-type exercise training on skeletal muscle mass (i.e. quadriceps cross-sectional area and whole body lean mass) in young old and oldest old subjects. Specific goals
• Determine whether resistance-type exercise training can increase muscle mass and muscle strength in young old and oldest old subjects.
• Determine whether resistance-type exercise training can improve physical performance in young old and oldest old subjects.
• Identify whether inflammatory markers (i.e., TNFα, IL-4, IL-6, IL-10, IL-13) are up- or down-regulated in young old and oldest old subjects before and after resistance-type exercise training. Methodology: Study design Sixty older females and males (young old group: n=30, 65-75 y; oldest old group: n=30, 85 y and over) will be included in this prospective clinical trial. All volunteers will be subjected to 12 weeks of whole-body resistance-type exercise training (3x/wk). Before, and after 6 and 12 weeks of training, a computed tomography (CT) scan of the upper leg will be performed to assess quadriceps cross sectional area. On those days, fasting blood samples will be obtained and whole-body dual energy x-ray absorptiometry (DEXA) scan will also be performed. Maximal strength will be determined by 1-repetition maximum (1RM) and physical functioning by the short physical performance battery (SPPB) at the same time points.

Conditions

Aged, 80 and Over; Resistance Training

Keywords

oldest old; exercise; muscle mass; strength; functional capacity

Outcome Measures

Primary Outcomes (1)

• Change in skeletal muscle mass (measured via Computed tomography (CT) scan) after prolonged resistance-type exercise training

  Cross-sectional area of the quadriceps and L3 region via single-slice CT scan

  Before, and after 6 and 12 weeks of training

Secondary Outcomes (5)

• Change in lean tissue (measured via Dual Energy X-ray Absorptiometry (DEXA) scan) after prolonged resistance-type exercise training

  Before, and after 6 and 12 weeks of training

• Change in arms and legs strength (measured via 1-Repetition Maximum (1RM) testing) after prolonged resistance-type exercise training

  Before, and after 6 and 12 weeks of training

• Change in hand grip strength (measured via JAMAR handheld dynamometer) after prolonged resistance-type exercise training

  Before, and after 6 and 12 weeks of training

• Change in physical performance (measured via Short physical performance battery (SPPB)) after prolonged resistance-type exercise training

  Before, and after 6 and 12 weeks of training

• Change in Inflammatory markers via ELISA after prolonged resistance-type exercise training

  Before, and after 6 and 12 weeks of training,

Study Arms (2)

65 - 75 years

EXPERIMENTAL

All volunteers aged 65 - 75 will be subjected to 12 weeks of full body resistance exercise training (3 times per week).

Other: Prolonged resistance-type exercise training

85 years and over

EXPERIMENTAL

All volunteers over the age of 85 will be subjected to 12 weeks of full body resistance exercise training (3 times per week).

Other: Prolonged resistance-type exercise training

Interventions

Prolonged resistance-type exercise training OTHER

All volunteers will be subjected to 12 weeks of whole-body resistance-type exercise training (3x/wk).

65 - 75 years; 85 years and over

Eligibility Criteria

• Age: 65 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Older Adult (65+)

You may qualify if:

• Aged from 65-75 and 85 and more years.
• \< BMI \< 30 kg/m2.
• Older people that are still "community-dwelling", i.e., not living in a nursing-home or elderly-home.

You may not qualify if:

• Performing regular resistance training (2 or more times per week, carrying out progressive training) in the previous 6 months.
• Cardiovascular diseases that are contradictory for physical activity (not included controlled Hypertension).
• All co-morbidities interacting with mobility and muscle metabolism of the body and that do not allow to (safely) perform the resistance-type exercise program (e.g. debilitating arthritis, spasticity/rigidity, all neurological disorders and paralysis).

Sponsors & Collaborators

• Universidad de La Frontera: lead
• Fondo Nacional de Desarrollo Científico y Tecnológico, Chile: collaborator

Study Sites (1)

Department of Internal Medicine, Faculty of Medicine, Universidad de La Frontera. Temuco, Chile

Temuco, Chile

Location

MeSH Terms

Conditions

Motor Activity

Condition Hierarchy (Ancestors)

Behavior

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: July 26, 2021
• First Posted: August 11, 2021
• Study Start: June 10, 2018
• Primary Completion: July 8, 2021
• Study Completion: October 30, 2022
• Last Updated: November 3, 2022

Record last verified: 2022-11

Locations

CL (1)