Variable Resistance Training in Patients With Osteoarthrosis of the Knee

NCT03722277 | Unknown

• 1 other identifier: Variable Load
• Study Type: interventional
• Target: 36
• Locations: 0 countries
• Sites: N/A

Brief Summary

This is a randomized controlled trial investigating the effect of variable load training in patients with knee osteoarthrosis. The intervention will consist of resistance training with variable load in knee extension- and flexion. The control group will receive conventional strength training with rubber band. Outcome measures will be the Knee Osteoarthrosis Outcome Score, functional capacity measured in a sit to stand test, 30m. pace walk and a 9 step stair climb test. Additionally isometric strength in knee flexion- and extension will be measured.

Conditions

Resistance Training

Outcome Measures

Primary Outcomes (1)

• Change in self reported knee function

  Knee Osteoarthrosis Outcome Score (100-0, 100 indicating no symptoms and 0 indicating extreme symptoms)

  At baseline and 10 weeks follow up

Secondary Outcomes (4)

• Change in functional capacity

  At baseline and 10 weeks follow up

• Change in isometric strength

  At baseline and 10 weeks follow up

• Change in functional capacity

  At baseline and 10 weeks follow up

• Change in functional capacity

  At baseline and 10 weeks follow up

Study Arms (2)

Variable load training

EXPERIMENTAL

The participants will be training two times per week in 10 weeks. Training will consist of variable load training in knee flexion- and extension. Training will be based on symptoms in isometric strength at five different angles of flexion- and extension.

Other: Variable load training

Conventional strength training

ACTIVE COMPARATOR

The participants will be training two times per week in 10 weeks. Training will consist of a training programme consisting of strength training with rubber bands for hip and knee.

Other: Conventional strength training

Interventions

Variable load training OTHER

Based on symptoms/strength measured in an isometric maximum strength test at five different angles of knee flexion- and extension, participants will be training with variable load during both concentric and excentric phase of the dynamic movement. Initially participants will start at 40% of symptom limited isometric strength, this will increase to 50% during the training period.

Variable load training

Conventional strength training OTHER

Conventional strength training with rubber bands in knee flexion- and extension, additionally hip abduction- and adduction.

Conventional strength training

Eligibility Criteria

• Age: 50 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Knee pain and minimum three of the following
• \>50 years
• morning stiffness \< 30 min
• crepitation
• bone tenderness
• bone osteophytes
• absence of inflammation

You may not qualify if:

• Other causes of symptoms to the knee

Sponsors & Collaborators

• University College South Denmark: lead

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: INVESTIGATOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: October 18, 2018
• First Posted: October 26, 2018
• Study Start: October 22, 2018
• Primary Completion: December 31, 2019
• Study Completion: September 1, 2020
• Last Updated: October 26, 2018

Record last verified: 2018-10

Data Sharing

• IPD Sharing: Will not share