COPD Co-infection With Tuberculosis on Th17 Cell Differentiation

NCT04966052 | Completed

• 1 other identifier: M2017390
• Study Type: observational
• Target: 80
• Locations: 1 country
• Sites: 1

Brief Summary

This project will observe and follow up the changes of pulmonary function and CT in patients with smoking combined with pulmonary tuberculosis, and measure the ratio of Th1 cells, Th17 cells, macrophages and neutrophils and the secretion of factors such as TNF-α, IFN-γ and IL-17 in pulmonary blood and alveolar lavage fluid.

Conditions

Tuberculosis Infection; Chronic Obstructive Pulmonary Disease

Outcome Measures

Primary Outcomes (1)

• Differentiation of Th17 cells

  Distribution of T cell subtypes, including CD4+, CD8+ T cells and Th17 cells, in blood specimens and alveolar lavage fluid by flow cytometry

  Day 1

Study Arms (4)

COPD combined with TB group

COPD combined with pulmonary TB infection

Other: No intervention

COPD non-TB control group

COPD combined without pulmonary TB infection

TB non-COPD control group

pulmonary TB infection without COPD

Non-smoking non-TB control group

Non-smoking without pulmonary TB infection

Interventions

No intervention OTHER

No intervention

COPD combined with TB group

Eligibility Criteria

• Age: 40 Years+
• Sex: all
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients seen at Peking University Third Hospital and Beijing Geriatric Hospital Respiratory Department from April 1, 2018 to April 1, 2020

You may qualify if:

• Clinical diagnosis of COPD
• age ≧ 40

You may not qualify if:

• Presence of other chronic respiratory diseases other than COPD, such as asthma, bronchiectasis, interstitial lung disease, etc.
• History of chest and lung surgery.
• History of malignancy.
• Autoimmune disease.
• Long-term oral glucocorticoids, immunosuppressants and inhaled glucocorticoids.
• Mental abnormalities, cognitive impairment, inability to cooperate with pulmonary function and other tests.
• Acute stage of infection, such as lung infection, urinary tract infection and gastrointestinal tract infection, etc.

Sponsors & Collaborators

• Peking University Third Hospital: lead
• Beijing Geriatric Hospital: collaborator

Study Sites (1)

Peking University Third Hospital

Beijing, Beijing Municipality, 100191, China

Location

Related Publications (1)

• Gai X, Cao W, Rao Y, Zeng L, Xu W, Wu H, Li G, Sun Y. Risk factors and biomarkers for post-tuberculosis lung damage in a Chinese cohort of male smokers and non-smokers: protocol for a prospective observational study. BMJ Open. 2023 Oct 9;13(10):e065990. doi: 10.1136/bmjopen-2022-065990.

  PMID: 37813532 DERIVED

Biospecimen

Retention: SAMPLES WITHOUT DNA

The distribution of T-cell subtypes, including CD4+ and CD8+ T cells and Th17 cells, in blood specimens and alveolar lavage fluid was detected by flow cytometry.

MeSH Terms

Conditions

Latent Tuberculosis; Pulmonary Disease, Chronic Obstructive

Condition Hierarchy (Ancestors)

Tuberculosis; Mycobacterium Infections; Actinomycetales Infections; Gram-Positive Bacterial Infections; Bacterial Infections; Bacterial Infections and Mycoses; Infections; Latent Infection; Lung Diseases, Obstructive; Lung Diseases; Respiratory Tract Diseases; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Yongchang Sun, MD

  Peking University 3rd Hospital

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: July 4, 2021
• First Posted: July 19, 2021
• Study Start: April 1, 2018
• Primary Completion: April 1, 2020
• Study Completion: June 1, 2020
• Last Updated: July 19, 2021

Record last verified: 2020-07

Locations

CN (1)