The Differences of Muscle Activity Between Patients With COPD and Healthy Adults

NCT04146948 | Unknown

• 1 other identifier: A-ER-108-273
• Study Type: observational
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study attempts to investigate the differences and relationships of respiratory parameters, muscle activity, and dyspnea during ADL between patients with COPD and age-matched healthy participants.

Conditions

Chronic Obstructive Pulmonary Disease

Keywords

activities of daily living; accessory inspiratory muscles; oxygen consumption; minute ventilation volume

Outcome Measures

Primary Outcomes (5)

• Cardiopulmonary exercise testing device

  The machine analyze the breath of participants including oxygen consumption and minute ventilation volume. Oxygen consumption is reported in mL/min and minute ventilation volume is reported in L/min.

  baseline

• Surface electromyography device

  The surface EMG is performed to assess the maximum voluntary contraction and muscle activity of upper limb muscles and accessory inspiratory muscles during performing simulated ADL tasks. The maximal voluntary contraction (MVC) is used as the reference level of muscle activity to normalize the EMG data of performing simulated ADL tasks. The muscle activity is reported in percentage.

  baseline

• The clinical Chronic Obstructive Pulmonary Disease questionnaire

  This is a self-reported questionnaire to measure the impact of COPD on participants' health status. The rating scores is a 7-point scale (0=no limitation, 6=totally limited).Higher scores mean the more severe impact of COPD on participants' daily living.

  baseline

• Modified Borg Scale

  This is a self-reported scale to measure how much participants perceive dyspnea. The range from 0 which means no difficulty to breathe to 10 which means with maximal difficulty to breathe.

  baseline

• Modified Medical Research Council

  This is a five-point scale to assess the severity of breathlessness.

  baseline

Secondary Outcomes (1)

• EQ-5D questionnaire

  baseline

Study Arms (2)

COPD group

No intervention 40 years or older, clinical diagnosis of COPD (Global Initiative for Chronic Obstructive Lung Disease stages I to IV)

Other: no intervention

healthy group

40 years or older, not with the clinical diagnosis of COPD

Other: no intervention

Interventions

no intervention OTHER

no intervention in this study

COPD group; healthy group

Eligibility Criteria

• Age: 40 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Participants with COPD will be recruited from the Department of Internal Medicine in National Cheng Kung University Hospital

You may qualify if:

• years or older
• With the clinical diagnosis of COPD

You may not qualify if:

• With the clinical diagnosis of asthma or cancer
• With cardiovascular, musculoskeletal and neurological diseases limiting physical activities in daily life
• In the unstable medical state
• MMSE under 25
• Barthel index score under 61

Sponsors & Collaborators

• National Cheng-Kung University Hospital: lead

Study Sites (1)

National Cheng-Kung University

Tainan, 701, Taiwan

RECRUITING

Related Publications (1)

• Chen CY, Hsu CH, Tsai SH, Lin CF, Lin YC, Hsu HY, Chen CZ, Kuo LC. Association Between Muscle Activity of Upper Limbs and Respiratory Parameters During Functional Performance in People With Chronic Obstructive Pulmonary Disease. Occup Ther Int. 2025 Mar 25;2025:3023322. doi: 10.1155/oti/3023322. eCollection 2025.

  PMID: 40171139 DERIVED

MeSH Terms

Conditions

Pulmonary Disease, Chronic Obstructive

Condition Hierarchy (Ancestors)

Lung Diseases, Obstructive; Lung Diseases; Respiratory Tract Diseases; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: October 28, 2019
• First Posted: October 31, 2019
• Study Start: January 22, 2020
• Primary Completion: December 1, 2021
• Study Completion: December 1, 2021
• Last Updated: April 1, 2021

Record last verified: 2021-03

Locations

TW (1)