A Study Evaluating the Efficacy and Safety of Adjuvant Giredestrant Compared With Physician's Choice of Adjuvant Endocrine Monotherapy in Participants With Estrogen Receptor-Positive, HER2-Negative Early Breast Cancer (lidERA Breast Cancer)
A Phase III, Randomized, Open-Label, Multicenter Study Evaluating the Efficacy and Safety of Adjuvant Giredestrant Compared With Physician's Choice of Adjuvant Endocrine Monotherapy in Patients With Estrogen Receptor-Positive, HER2-Negative Early Breast Cancer
3 other identifiers
interventional
4,170
50 countries
585
Brief Summary
This is a Phase III, global, randomized, open-label, multicenter, study evaluating the efficacy and safety of adjuvant giredestrant compared with physician's choice of endocrine therapy in participants with medium- and high-risk Stage I-III histologically confirmed estrogen receptor (ER)-positive and human epidermal growth factor receptor 2 (HER2)-negative early breast cancer.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for phase_3
Started Aug 2021
Longer than P75 for phase_3
585 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
July 5, 2021
CompletedFirst Posted
Study publicly available on registry
July 14, 2021
CompletedStudy Start
First participant enrolled
August 27, 2021
CompletedPrimary Completion
Last participant's last visit for primary outcome
August 8, 2025
CompletedStudy Completion
Last participant's last visit for all outcomes
January 1, 2035
ExpectedFebruary 20, 2026
February 1, 2026
4 years
July 5, 2021
February 18, 2026
Conditions
Outcome Measures
Primary Outcomes (1)
Invasive Disease-Free Survival (IDFS), Excluding Second Primary Non-Breast Cancers
From randomization to first occurrence of an IDFS event (up to 10 years)
Secondary Outcomes (15)
Overall Survival
From randomization to death from any cause (up to 10 years)
Invasive Disease-Free Survival (IDFS), Including Second Primary Non-Breast Cancers
From randomization to first occurrence of an IDFS event (up to 10 years)
Disease-Free Survival (DFS)
From randomization to first occurrence of a DFS event (up to 10 years)
Distant Recurrence-Free Interval (DRFI)
From randomization to first occurrence of a DFRI event (up to 10 years)
Locoregional Recurrence-Free Interval (LRRFI)
From randomization to first occurrence of a LRRFI event (up to 10 years)
- +10 more secondary outcomes
Study Arms (2)
Arm A: Giredestrant
EXPERIMENTALArm B: Physician's Choice of Endocrine Therapy
ACTIVE COMPARATORInterventions
Giredestrant 30 milligrams (mg) will be administered orally once a day (QD) on Days 1-28 of each 28-day cycle for 5 years or until disease recurrence or unacceptable toxicity (whichever occurs first).
A luteinizing hormone-releasing hormone (LHRH) agonist will be administered to male participants and premenopausal/perimenopausal participants according to local prescribing information. The investigator may determine and supply the appropriate LHRH agonist locally approved for use in breast cancer.
The physician's choice of endocrine therapy (PCET) is limited to tamoxifen or one of the specified third generation aromatase inhibitors: letrozole, anastrozole, or exemestane. Participants will receive PCET daily on Days 1-28 of each 28-day cycle for 5 years or until disease recurrence or unacceptable toxicity (whichever occurs first). Continuing PCET after 5 years is at the discretion of the investigator and per local standard of care. Dose administration of PCET should be performed in accordance with the local prescribing information for the respective product.
Eligibility Criteria
You may qualify if:
- Documented estrogen receptor (ER)-positive and HER2-negative breast tumor, as assessed locally on a primary disease specimen
- Participants who have multicentric (the presence of two of more tumor foci within different quadrants of the same breast) and/or multifocal (the presence of two or more tumor foci within a single quadrant of the breast) breast cancer are also eligible if all examined tumors meet pathologic criteria for ER positivity and HER2 negativity
- Participants must have undergone definitive surgery of their primary breast tumor(s) and axillary lymph nodes (axillary lymph node dissection \[ALND\] and/or sentinel lymph node biopsy \[SLNB\])
- Participants who received or will be receiving adjuvant chemotherapy must have completed adjuvant chemotherapy prior to randomization. Participants may also have received neoadjuvant chemotherapy. A washout period of at least 21 days is required between last adjuvant chemotherapy dose and randomization.
- Resolution of all acute toxic effects of prior anti-cancer therapy or surgical procedures to NCI CTCAE v5.0 Grade 1 or better (except alopecia, Grade ≤2 peripheral neuropathy, arthralgia or other toxicities not considered a safety risk for the participant per the investigator's judgment)
- Participants have received (neo)adjuvant chemotherapy and/or had surgery and had no prior endocrine therapy are eligible, provided that they are enrolled within 12 months following definitive breast cancer surgery
- Participants who have confirmed availability of an untreated primary breast tumor tissue specimen suitable for biomarker testing (i.e., representative archived formalin-fixed, paraffin-embedded \[FFPE\] tissue block \[preferred\] or 15-20 slides containing unstained, freshly cut, serial sections), with associated de-identified pathology report is required. Although 15-20 slides are preferred, if only 10-14 slides are available, the individual may still be eligible for the study.
- Participants with node-positive and node-negative disease are eligible provided they meet additional risk criteria as defined in the protocol
- Eastern Cooperative Oncology Group (ECOG) Performance Status 0, 1, or 2
- Able and willing to swallow, retain, and absorb oral medication
- Adequate organ function
You may not qualify if:
- Pregnant or breastfeeding, or intending to become pregnant during the study or within 10 days after the final dose of giredestrant, or within the time period specified per local prescribing guidelines after the final dose of the endocrine therapy of physician's choice
- Received treatment with investigational therapy within 28 days prior to initiation of study treatment or is currently enrolled in any other type of medical research judged by the sponsor not to be scientifically or medically compatible with this study
- Receiving or planning to receive a CDK4/6 inhibitor as (neo)adjuvant therapy. A short course of up to 12 weeks of neoadjuvant or adjuvant treatment with CDK4/6 inhibitor therapy prior to randomization is allowed.
- Active cardiac disease or history of cardiac dysfunction
- Diagnosed with Stage IV breast cancer
- A history of any prior (ipsilateral and/or contralateral) invasive breast cancer or ductal carcinoma in situ (DCIS). Participants with a history of contralateral DCIS treated by only local regional therapy at any time may be eligible.
- A history of any other malignancy within 3 years prior to screening, except for appropriately treated carcinoma in situ of the cervix, nonmelanoma skin carcinoma, or Stage I uterine cancer
- Any prior endocrine treatment with selective ER modulators (e.g., tamoxifen), degraders, or aromatase inhibitors. A short course of neoadjuvant or adjuvant endocrine therapy (up to 12 weeks) is allowed.
- Clinically significant liver disease consistent with Child-Pugh Class B or C, including active hepatitis (e.g., hepatitis B virus \[HBV\] or hepatitis C virus \[HCV\]), current alcohol abuse, cirrhosis, or positive test for viral hepatitis
- Treatment with strong CYP3A4 inhibitors or inducers within 14 days or 5 drug elimination half-lives (whichever is longer) prior to initiation of study treatment
- Known allergy or hypersensitivity to any of the study drugs or any of their excipients
- Pre- and perimenopausal participants or male participants who have a known hypersensitivity to LHRH agonists
- A documented history of hemorrhagic diathesis, coagulopathy, or thromboembolism
- Renal dysfunction that requires dialysis
- A major surgical procedure unrelated to breast cancer within 28 days prior to randomization
- +3 more criteria
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (622)
Southern Cancer Center
Daphne, Alabama, 36526, United States
CBCC Global Research Inc., at Comprehensive Blood and Cancer Center
Bakersfield, California, 93309, United States
St Joseph Heritage Healthcare
Fullerton, California, 92835, United States
Long Beach Memorial Medical Center
Long Beach, California, 90806, United States
Cancer Blood and Specialty Clinic
Los Alamitos, California, 90720, United States
The Center for Cancer Prevention and Treatment at St.Joseph Hospital of Orange
Orange, California, 92868, United States
Kaiser Permanente - San Diego
San Diego, California, 92120, United States
Sansum Clinic
Santa Barbara, California, 93105, United States
UCLA Hematology/Oncology
Santa Monica, California, 90404, United States
Torrance Memorial Physician Network/Cancer Care
Torrance, California, 90505, United States
Kaiser Permanente - Vallejo
Vallejo, California, 94589, United States
Rocky Mountain Cancer Centers (Longmont) - USOR
Longmont, Colorado, 80501, United States
Stamford Hospital
Stamford, Connecticut, 06902, United States
Memorial Healthcare System - Memorial Regional Hospital
Hollywood, Florida, 33021, United States
Baptist - MD Anderson Cancer Center
Jacksonville, Florida, 32207, United States
Mount Sinai Comprehensive Cancer Center
Miami Beach, Florida, 33140, United States
University of Chicago Hospital
Chicago, Illinois, 60637, United States
Duly Health and Care
Tinley Park, Illinois, 60487, United States
Cancer Center of Kansas - Kingman
Kingman, Kansas, 67068, United States
University of Kentucky
Lexington, Kentucky, 40536, United States
Norton Cancer Institute - MDC
Louisville, Kentucky, 40202, United States
Hematology/Oncology Clinic, LLP
Baton Rouge, Louisiana, 70809, United States
University Medical Center New Orleans
New Orleans, Louisiana, 70112, United States
University of Maryland
Towson, Maryland, 21204, United States
Lahey Clinic Med Ctr
Burlington, Massachusetts, 01805, United States
Massachusetts General Hospital
Lexington, Massachusetts, 02421, United States
University Of Michigan
Ann Arbor, Michigan, 48109, United States
Metro-Minnesota Community Oncology Research Consortium
Saint Louis Park, Minnesota, 55426, United States
University of Missouri-Columbia
Columbia, Missouri, 65203, United States
St. Vincent Frontier Cancer Center
Billings, Montana, 59102, United States
Nebraska Cancer Specialists
Omaha, Nebraska, 68130-2042, United States
Comprehensive Cancer Centers of Nevada
Las Vegas, Nevada, 89135, United States
Hunterdon Hematology Oncology
Flemington, New Jersey, 08822, United States
Rutgers Cancer Institute of New Jersey
New Brunswick, New Jersey, 08901, United States
New York University Cancer Cen
New York, New York, 10016, United States
Stony Brook Univ Cancer Ctr
Stony Brook, New York, 11794, United States
Messino Cancer Centers
Asheville, North Carolina, 28806, United States
Rex Cancer Center
Raleigh, North Carolina, 27607, United States
Atrium Health Wake Forest Baptist Medical Center - PPDS
Winston-Salem, North Carolina, 27157, United States
Aultman Hospital
Canton, Ohio, 44710, United States
University Hospitals Cleveland Medical Center
Cleveland, Ohio, 44106, United States
Columbus NCORP
Columbus, Ohio, 43125, United States
Stefanie Spielman Comprehensive Breast Center
Columbus, Ohio, 43212, United States
Oncology Associates of Oregon, P.C.
Eugene, Oregon, 97401, United States
Kaiser Permanente-Northwest Region
Portland, Oregon, 97227, United States
Pinnacle Health
Harrisburg, Pennsylvania, 17109, United States
Penn State Univ. Milton S. Hershey Medical Center
Hershey, Pennsylvania, 17033, United States
Allegheny Cancer Center
Pittsburgh, Pennsylvania, 15212-4737, United States
Magee Womens Hospital
Pittsburgh, Pennsylvania, 15213, United States
Reading Hospital
West Reading, Pennsylvania, 19611, United States
Women & Infants Hospital
Providence, Rhode Island, 02905, United States
Avera Cancer Institute
Sioux Falls, South Dakota, 57105, United States
West Cancer Center & Research Institute
Germantown, Tennessee, 38138-1762, United States
Sarah Cannon Research Institute / Tennessee Oncology
Nashville, Tennessee, 37203, United States
Texas Oncology, P.A. - El Paso
El Paso, Texas, 79902, United States
Texas Oncology (Flower Mound) - USOR
Flower Mound, Texas, 75028, United States
Texas Oncology-Fort Worth Cancer Center
Fort Worth, Texas, 76104, United States
Baylor College of Medicine Medical Center
Houston, Texas, 77030, United States
Houston Methodist Cancer Center
Houston, Texas, 77030, United States
Joe Arrington Cancer Research & Treatment Center
Lubbock, Texas, 79410, United States
Texas Oncology (McAllen) - USOR
McAllen, Texas, 78503, United States
USOR - Texas Oncology - San Antonio Northeast
San Antonio, Texas, 78217, United States
Texas Oncology (Tyler) - USOR
Tyler, Texas, 75702-8363, United States
Texas Oncology (Waco) - USOR
Waco, Texas, 76712, United States
Centra Alan B. Pearson Regional Cancer Center
Lynchburg, Virginia, 24501, United States
Bon Secours Mercy Health
Midlothian, Virginia, 23114, United States
Virginia Oncology Associates
Norfolk, Virginia, 23502, United States
Virginia Commonwealth University - Massey Cancer Center
Richmond, Virginia, 23298, United States
Oncology and Hematology Associates of Southwest Virginia, Inc.,-Blacksburg
Roanoke, Virginia, 24014, United States
Swedish Cancer Institute
Seattle, Washington, 98104, United States
West Virginia University Hospitals Inc
Morgantown, West Virginia, 26056, United States
University of Wisconsin
Madison, Wisconsin, 53792, United States
Centro de Investigaciones Médicas y Desarrollo LC S.R.L
Buenos Aires, Ciudad Autónoma de BuenosAires, C1113AAE, Argentina
Fundacion Intectus
Bariloche, Río Negro Province, 8400, Argentina
Hospital Italiano Regional del Sur
Bahía Blanca, 8000, Argentina
Instituto de Investigaciones Clinicas-Mar del Plata
Buenos Aires, B7600FZN, Argentina
Instituto de Investigaciones Metabólicas (IDIM)
Buenos Aires, C1012, Argentina
Centro Oncologico Korben
Caba, C1426AGE, Argentina
Fundacion Medica de Rio Negro Y Nuequen
Cipolletti, 8324, Argentina
Consultorios Médicos Dr. Doreski
Ciudad Autonoma Buenos Aires, C1426ABP, Argentina
Sanatorio Allende Servicio Nefrología
Córdoba, 5000, Argentina
Centro Medico Privado CEMAIC
Córdoba, X5008AAC, Argentina
Centro Oncologico Riojano Integral (CORI)
La Rioja, F5300COE, Argentina
Centro de Investigaciones Medicas Mar Del Plata
Mar del Plata, B7600FYK, Argentina
Hospital Privado de La Comunidad
Mar del Plata, B7603CBM, Argentina
Centro de Investigacion Pergamino SA
Pergamino, B2700CPM, Argentina
Exelsus clinica Oncologica
Provincia de Tucumán, T4000, Argentina
Instituto Medico de la Fundacion Estudios Clinicos
Rosario, 2000, Argentina
Instituto de Especialidades de la Salud Rosario - Clínica del Tórax
Rosario, S2000DBS, Argentina
Sanatorio Parque de Rosario
Rosario, S2000DSV, Argentina
Instituto de Oncologia de Rosario
Rosario, S2013KZE, Argentina
Centro Polivalente de Asistencia e Investigacion Clinica - CER San Juan
San Juan, J5402DIL, Argentina
Centro Médico Privado de Reumatología
San Miguel de Tucumán, T4000AXL, Argentina
Organizacion Medica de Investigacion
San Nicolás, C1015ABO, Argentina
Fundación Ars Medica
San Salvador de Jujuy, Argentina
Centro de Investigación Clínica ? Clínica Viedma
Viedma, R8500ACE, Argentina
Border Medical Oncology Research Unit
Albury, New South Wales, 2640, Australia
Campbelltown Hospital
Campbelltown, New South Wales, 2560, Australia
Liverpool Hospital
Liverpool, New South Wales, 2170, Australia
Westmead Hospital
Northmead, New South Wales, 2152, Australia
North Coast Cancer Institute - Port Macquarie
Port Macquarie, New South Wales, 2444, Australia
Mater Hospital
Wollstonecraft, New South Wales, 2065, Australia
Wesley Medical Centre
Auchenflower, Queensland, 4066, Australia
Mater Cancer Care Centre
Brisbane, Queensland, 4101, Australia
Cairns Hospital
Cairns, Queensland, 4870, Australia
Townsville Hospital
Townsville, Queensland, 4810, Australia
Princess Alexandra Hospital
Woolloongabba, Queensland, 4102, Australia
Royal Adelaide Hospital
Adelaide, South Australia, 5000, Australia
St Andrews Medical Centre
Adelaide, South Australia, 5000, Australia
Flinders Medical Centre
Bedford Park, South Australia, 5042, Australia
Ashford Cancer Centre Research
Kurralta Park, South Australia, 5037, Australia
ICON Cancer Care Hobart
Hobart, Tasmania, 7000, Australia
Bendigo Hospital
Bendigo, Victoria, 3550, Australia
Northern Hospital
Epping, Victoria, 3076, Australia
Frankston Hospital
Frankston, Victoria, 3199, Australia
Maroondah Hospital
Ringwood East, Victoria, 3135, Australia
Goulburn Valley Health
Shepparton, Victoria, 3630, Australia
Sunshine Hospital
St Albans, Victoria, 3021, Australia
South West Healthcare
Warrnambool, Victoria, 3280, Australia
Ballarat Oncology & Haematology
Wendouree, Victoria, 3355, Australia
Sir Charles Gairdner Hospital
Nedlands, Western Australia, 6009, Australia
LKH-Universitätsklinikum Klinikum Graz
Graz, 8036, Austria
Medizinische Universitat Innsbruck
Innsbruck, 6020, Austria
LKH Rankweil, Interne E
Rankweil, 6830, Austria
Universitätsklinikum Salzburg
Salzburg, 5020, Austria
Universitätsklinikum St. Pölten
Sankt Pölten, 3100, Austria
A.ö. Krankenhaus der Barmherzigen Brüder
Sankt Veit im Pongau, 9300, Austria
Oö. Gesundheits- und Spitals-AG/LKH Steyr
Steyr, 4400, Austria
Medizinische Universitat Wien Medical University of Vienna
Vienna, 1090, Austria
Klinikum Wels-Grieskirchen GmbH
Wels, 4600, Austria
Institute Jules Bordet
Belgium, 1000, Belgium
Grand Hopital de Charleroi asbl
Charleroi, 6000, Belgium
CH de l'Ardenne (Libramont)
Libramont, 6800, Belgium
Centre Hospitalier Chrétien MontLégia
Liège, 4000, Belgium
CHR de la Citadelle, Pharmacie
Liège, 4000, Belgium
Chu Sart Tilman
Liège, 4000, Belgium
Clinique Sainte-Elisabeth
Namur, 5000, Belgium
Cliniques Universitaires UCL de Mont-Godinne
Namur, 5530, Belgium
GZA Ziekenhuizen Antwerpen campus Sint-Augustinus
Wilrijk, 2610, Belgium
Clinical Center Banja Luka
Banja Luka, 78000, Bosnia and Herzegovina
Clinical Hospital Mostar
Mostar, 88000, Bosnia and Herzegovina
University Clinical Center Tuzla
Tuzla, 75000, Bosnia and Herzegovina
Centro de Pesquisas Clinicas em Oncologia - CPCO
Cachoeiro de Itapemirim, Espírito Santo, 29308-014, Brazil
Nucleo de Oncologia da Bahia - NOB
Salvador, Bahia, Estado de Bahia, 40170-380, Brazil
Centro de Oncologia da Bahia
Salvador/BA, Estado de Bahia, 41820-021, Brazil
Hospital Araujo Jorge
Goiânia, Goiás, 74605-070, Brazil
Hospital Mae de Deus
Pôrto Alegre, Mato Grosso do Sul, 90110-270, Brazil
Cenantron - Centro Avancado de Tratamento Oncologico
Belo Horizonte, Minas Gerais, 30130-090, Brazil
Oncoclinicas do Brasil Servicos Medicos As
Belo Horizonte, Minas Gerais, 30360-680, Brazil
Hospital de Clinicas de Porto Alegre HCPA PPDS
Pôrto Alegre, Pará, 90035-903, Brazil
Hospital do Cancer de Pernambuco - HCP
Recife, Pernambuco, 50040-000, Brazil
Universidade de Caxias do Sul - Rio Grande do Sul
Caixas Do Sul, Rio Grande do Sul, 95070-560, Brazil
ONCOSITE Centro de Pesquisa Clínica Em Oncologia
Ijuí, Rio Grande do Sul, 98700-000, Brazil
Hospital Bruno Born
Lajeado, Rio Grande do Sul, 95900-000, Brazil
Hospital São Vicente de Paulo X
Passo Fundo, Rio Grande do Sul, 99001-970, Brazil
Hospital Moinhos de Vento
Porto Alegre, Rio Grande do Sul, 90035-001, Brazil
Irmandade Da Santa Casa de Misericordia de Porto Alegre
Porto Alegre, Rio Grande do Sul, 90050-170, Brazil
Hospital Sao Lucas - PUCRS
Porto Alegre, Rio Grande do Sul, 90610-000, Brazil
Hospital Nossa Senhora da Conceição
Porto Alegre, Rio Grande do Sul, 91350-200, Brazil
Clinica de Neoplasias Litoral
Itajaí, Santa Catarina, 88301-220, Brazil
*X*Fundação Pio XII Hospital de Câncer de Barretos
Barretos, São Paulo, 14784-400, Brazil
Hospital Amaral Carvalho
Jaú, São Paulo, 17210-120, Brazil
Instituto de Oncologia Clínica de Piracicaba
Piracicaba, São Paulo, 13419-160, Brazil
Faculdade de Medicina do ABC - FMABC
Santo André, São Paulo, 09060-650, Brazil
Fundação Faculdade Regional de Medicina de São José do Rio Preto
São José do Rio Preto, São Paulo, 15090-000, Brazil
Instituto do Cancer do Estado de Sao Paulo - ICESP
São Paulo, São Paulo, 01246-000, Brazil
Instituto Nacional de Cancer - INCa
Rio de Janeiro, 20560-120, Brazil
Instituto Brasileiro De Controle Do Câncer - IBCC
São Paulo, 03102-002, Brazil
Clinica de Pesquisas e Centro de Estudos Oncologia Ginecologica e Mamaria Ltda
São Paulo, 0317-0001, Brazil
Onco Star Sp Oncologia Ltda
São Paulo, 04543-000, Brazil
Complex Oncology Center Burgas
Burgas, 8000, Bulgaria
Multiprofile Hospital for Active Treatment Uni Hospital
Panagyurishte, 4500, Bulgaria
Arthur J.E. Child Comprehensive Cancer Center-Calgary
Calgary, Alberta, T2N 4N2, Canada
Cross Cancer Institute
Edmonton, Alberta, T6G 1Z2, Canada
British Columbia Cancer Agency
Vancouver, British Columbia, V5Z 4R2, Canada
The Moncton Hospital
Moncton, New Brunswick, E1C 6Z8, Canada
Sault Area Hospital
Sault Ste. Marie, Ontario, P6B 0A8, Canada
Centre Integre Universitaire de Sante et de Services Sociaux du Saguenay Lac Saint Jean
Chicoutimi, Quebec, G7H 5H6, Canada
Hopital Charles Le Moyne
Greenfield Park, Quebec, J4V 2H1, Canada
CIUSSS-de-l?Est-de-l?Île-de-Montréal
Montreal, Quebec, H1T 2M4, Canada
CHUM
Montreal, Quebec, H2X 3E4, Canada
Sir Mortimer B Davis Jewish General Hospital
Montreal, Quebec, H3T 1E2, Canada
McGill University Health Center
Montreal, Quebec, H4A 3J1, Canada
St-Jérome Medical Research, Inc.
Saint-Jérôme, Quebec, H7Z 5T3, Canada
Centre Hospitalier Universitaire de Sherbrooke
Sherbrooke, Quebec, J1H 5N4, Canada
Allan Blair Cancer Centre
Regina, Saskatchewan, S4T 7T1, Canada
CHU de Quebec-Universite Laval
Québec, G1S 4L8, Canada
Fundacion Arturo Lopez Perez (FALP) - Providencia - Jose Manuel Infante 805
Providencia, Región-MetropolitanadeSantiago, 7500000, Chile
IC La Serena Research SpA
La Serena, 1700000, Chile
Patagonia Research
Port Montt, 5480000, Chile
Centro de Estudios Clínicos SAGA SpA
Providencia, 7500000, Chile
Servicios Médicos URUMED SpA
Rancagua, Chile
Oncovida - Santiago
Santiago, 7510035, Chile
Meditek Ltda
Santiago, 8320000, Chile
Centro de Estudios Clinicos E Investigaciones Medicas
Santiago, 8330336, Chile
Icegclinic
Santiago, Chile
Medwal
Santiago, Chile
Clinica Universidad Catolica del Maule
Talca, 3460000, Chile
Clinica Alemana de Temuco
Temuco, 4810469, Chile
Oncocentro Apys
Viña del Mar, 2520598, Chile
Centro de Investigaciones Clinicas Viña del Mar
Viña del Mar, 2540333, Chile
Henan Cancer Hospital
Zhengzhou, Henan, 450008, China
Hunan Cancer Hospital
Changsha, Hunan, 410013, China
Jiangxi Cancer Hospital
Nanchang, Jiangxi, 330006, China
The First Hospital of Jilin University
Changchun, Jilin, 130021, China
West China Hospital, Sichuan University
Chengdu, Sichuan, 610041, China
Peking University People's Hospital
Beijing, 100044, China
Jilin Cancer Hospital
Changchun, 132013, China
The Second Affiliated Hospital of Dalian Medical University
Dalian, 116027, China
Fujian Provincial Cancer Hospital
Fuzhou, 350014, China
Guangdong Provincial Maternity and Child Care Cent
Guangzhou, 510010, China
Sun yat-sen University Cancer Center
Guangzhou, 510060, China
The First Affiliated Hospital of College of Medicine, Zhejiang University
Hangzhou, 310003, China
Zhejiang Cancer Hospital
Hangzhou, 310022, China
Harbin Medical University Cancer Hospital
Harbin, 150040, China
Anhui Province Cancer Hospital
Hefei, 230001, China
Jinan Central Hospital
Jinan, 250013, China
Linyishi Cancer Hospital
Linyi, 273316, China
The Third Hospital of Nanchang
Nanchang, 330009, China
Guangxi Cancer Hospital of Guangxi Medical University
Nanning, 530021, China
The Second People's Hospital of Neijiang
Neijiang, 641000, China
Fudan University Shanghai Cancer Center
Shanghai, 200032, China
Shengjing Hospital of China Medical University
Shenyang, 110004, China
Tianjin Medical University Cancer Institute & Hospital
Tianjin, 300060, China
Wenzhou Medical College - The First Affiliated Hospital GCP
Wenzhou, 325000, China
Union Hospital Tongji Medical College Huazhong University of Science and Technology
Wuhan, 430023, China
Tongji Hospital Tongji Medical College Huazhong University of Science and Technology
Wuhan, 430030, China
Hubei Cancer Hospital
Wuhan, 430079, China
Air Force Military Medical University Xijing Hospital
Xi'an, 710032, China
First Affiliated Hospital of Medical College of Xi'an Jiaotong University
Xi'an, 710061, China
The First Affiliated Hospital of Xiamen University
Xiamen, 361003, China
The Affiliated Hospital of Xuzhou Medical University
Xuzhou, China
Oncomedica S.A.
Montería, Departamento de Córdoba, 230001, Colombia
Hemato Oncólogos S.A
Cali, 760042, Colombia
FOSCAL
Floridablanca, Colombia
Oncólogos Del Occidente SA
Pereira, 660003, Colombia
Sociedad de Oncología y hematología del Cesar Ltda
Valledupar, 200001, Colombia
Policlínico San Bosco
San José, Alajuela Province, 20303, Costa Rica
Consultorio Oncologico-Hospital Metropolitano Linc
Moravia, 11401, Costa Rica
Metropolitano Research Institute Lindora
San José, 10903, Costa Rica
Centro de Cáncer y Hematología
San José, Costa Rica
Instituto de Investigación en Ciencias Médicas S.A.
San José, Costa Rica
General Hospital Pula
Pula, 52100, Croatia
University Hospital of Split
Split, 21000, Croatia
General Hospital Varazdin
Varaždin, 42000, Croatia
Clinical Hospital Sestre Milosrdnice - Medical Oncology Department
Zagreb, 10000, Croatia
Clinical Hospital Sestre Milosrdnice
Zagreb, 10000, Croatia
Klinicki bolnicki centar Zagreb
Zagreb, 10000, Croatia
Fakultni nemocnice Olomouc
Ostrava - Poruba, 708 52, Czechia
Fakultni nemocnice Kralovske Vinohrady
Prague, 100 34, Czechia
Vseobecna fakultni nemocnice v Praze
Prague, 121 11, Czechia
Fakultni Thomayerova Nemocnice
Prague, 140 59, Czechia
Mansoura University Hospital
Al Mansurah, 35516, Egypt
Alexandria Uni
Alexandria, Egypt
Medical Technology Center for Research and Services
Alexandria, Egypt
Kasr Al Ainy School of Medicine-Cairo University
Cairo, 11562, Egypt
Ain Shams University Hospital
Cairo, 11566, Egypt
Gustave Roussy International Egypt Hospital
Fostat, 11632, Egypt
Sohag Oncology Center
Markaz Sohag, 82511, Egypt
Helsingin yliopistollinen keskussairaala
Helsinki, 00290, Finland
Tampereen yliopistollinen sairaala
Tampere, 33520, Finland
Turun Yliopistollinen Keskussairaala
Turku, 20540, Finland
Centre Francois Baclesse
Caen, Calvados, 14000, France
Clinique Clémentville
Montpellier, Hérault, 34070, France
Hopital d'Argenteuil
Argenteuil, 95100, France
Centre Hospitalier Regional Universitaire de Brest - Hopital de la Cavale Blanche
Brest, 29200, France
Institut Daniel Hollard
Grenoble, 38000, France
Centre Hospitalier Departemental de Vendee
La Roche-sur-Yon, 85925, France
Centre de cancérologie de la Sarthe - Aile B
Le Mans, 72015, France
Centre Oscar Lambret
Lille, 59020, France
CHU Dupuytren
Limoges, 87042, France
Hôpital Privé Clairval
Marseille, 13273, France
Clinique Catherine de Sienne
Nantes, 44202, France
Hopital Universitaire Pitie Salpetriere
Paris, 75013, France
Hopital Tenon
Paris, 75020, France
Institut Curie
Paris, 75248, France
Hopital privé des Côtes Armor
Plérin, 22190, France
EDOG - Centre Eugene Marquis Centre Regional de Lutte Contre Le Cancer - PPDS
Rennes, 35042, France
Centre Henri Becquerel
Rouen, 76038, France
Curie Saint Cloud
Saint-Cloud, 92210, France
High Technology Hospital MedCenter Ltd
Batumi, 6000, Georgia
Acad. F. Todua Medical Center
Tbilisi, 0112, Georgia
Ltd Israel-Georgia Medical Research Clinic Helsicore
Tbilisi, 0112, Georgia
LTD Health House
Tbilisi, 0144, Georgia
Institute of Clinical Oncology LTD
Tbilisi, 0159, Georgia
LTD TIM, Tbilisi Institute of Medicine
Tbilisi, 0160, Georgia
Multiprofile Clinic Consilium Medulla
Tbilisi, 0186, Georgia
S Khechinashvili University Clinic Ltd
Tbilisi, 179, Georgia
Hämatologisch/onkologische Gemeinschaftspraxis
Augsburg, 86150, Germany
Ambulantes Tumorzentrum Spandau
Berlin, 13581, Germany
Klinikum Chemnitz gGmbH
Chemnitz, 09116, Germany
Universitatsklinikum Erlangen
Erlangen, 91054, Germany
KEM/Evang. Kliniken Essen Mitte gGmbH
Essen, 45136, Germany
Franziskus-Hospital Harderberg
Georgsmarienhütte, 49124, Germany
Mammazentrum Hamburg am Krankenhaus Jerusalem
Hamburg, 20357, Germany
Vincentius-Diakonissen-Kliniken gAG
Karlsruhe, 76137, Germany
Universitätsmedizin Mainz
Mainz, 55131, Germany
Klinikum Mannheim GmbH Universitätsklinikum
Mannheim, 68167, Germany
Praxis fuer gynaekologische onkologie Prof. Dr. me
Mönchengladbach, 41061, Germany
Hämatologie und Onkologie Ravensburg / Wangen
Ravensburg, 88212, Germany
Leopoldina Krankenhaus Schweinfurt
Schweinfurt, 97422, Germany
Praxis fur Haematologie und Internistische Onkologie
Velbert, 42551, Germany
European Interbalkan Medical Center; 3rd Department of Oncology
Pylaia, Thessaloniki, 570 01, Greece
European Interbalkan Medical Center
Pylaia, Thessaloniki, 570 01, Greece
Henry Dunant Hospital
Athens, 115 26, Greece
University of Athens, Hematological Clinic; First Department of Propaedeutic Medicine
Athens, 115 27, Greece
Aretaieio Hospital of Athens
Athens, 115 28, Greece
Sotiria Chest Hospital of Athens
Athens, 11527, Greece
General Oncology Hospital Kifissias "Oi Agioi Anargyroi"
Athens, 145 64, Greece
Attikon University General Hospital
Chaïdári, 124 62, Greece
Metropolitan General Hospital, A' Oncology Clinic
Cholargós, 155 62, Greece
Metropolitan General Hospital
Cholargós, 155 62, Greece
Metropolitan Hospital First Oncology Clinic
Faliro, 185 47, Greece
Metropolitan Hospital Fourth Oncology Clinic
Faliro, 185 47, Greece
University General Hospital of Heraklion
Heraklion, 711 10, Greece
University General Hospital of Ioannina
Ioannina, 455 00, Greece
University General Hospital of Larissa
Larissa, 412 21, Greece
IASO Obstetrics Gynecology Clinic
Marousi, 151 23, Greece
Medical Center of Athens
Marousi, 151 25, Greece
Olympion Clinic
Pátrai, 264 43, Greece
University General Hospital of Patras
Pátrai, 265 00, Greece
Bioclinic Thessaloniki
Thessaloniki, 546 22, Greece
Interbalkan Medical Center of Thessaloniki
Thessaloniki, 546 39, Greece
St. Luke's Hospital
Thessaloniki, 552 36, Greece
Papageorgiou General Hospital of Thessaloniki
Thessaloniki, 564 29, Greece
Celan S.A.
Guatemala City, 01010, Guatemala
INTEGRA Cancer Institute
Guatemala City, 01010, Guatemala
Oncomedica
Guatemala City, 01010, Guatemala
Grupo Medico Angeles
Guatemala City, 01015, Guatemala
Clínica Médica Especializada en Hematología
Guatemala City, 01234, Guatemala
Centro Medico Integral de Cancerologia CEMIC
Salcajá, 09002, Guatemala
Queen Mary Hospital
Hong Kong, Hong Kong
Tuen Mun Hospital
Hong Kong, Hong Kong
Semmelweis Egyetem
Budapest, 1082, Hungary
Tolna Megyei Balassa János Kórház
Budapest, 1136, Hungary
Budapesti Uzsoki Utcai Kórház
Budapest, 1145, Hungary
Debreceni Egyetem Klinikai Kozpont
Debrecen, 4032, Hungary
Borsod-Abauj-Zemplen Megyei Korhaz es Egyetemi Oktato Korhaz
Miskolc, 3526, Hungary
Szent Borbala Korhaz
Tatabánya, 2800, Hungary
Zala Megyei Szent Rafael Korhaz
Zalaegersteg, 8900, Hungary
HCG City Cancer Centre
Vijayawada, Andhra Pradesh, 520002, India
State Cancer Institute, Indira Gandhi Institute of Medical Sciences (IGIMS)
Patna, Bihar, 800014, India
Gujarat Cancer & Research Inst.
Ahmedabad, Gujarat, 380016, India
Nirmal Hospital
Surat, Gujarat, 395002, India
Kiran Hospital Multi Super Speciality Hospital and Research Center
Surat, Gujarat, 395004, India
Himalaya Cancer Hospital & Research Institute
Vadodara, Gujarat, 390020, India
Kailash Cancer Hospital and Research Center
Vadodara, Gujarat, 391760, India
KLES Dr Prabhakar Kore Hospital and Medical Research Centre
Belagavi, Karnataka, 590010, India
Sujan Surgical Cancer Hospital And Amravati Cancer Foundation
Amravati, Maharashtra, 444606, India
Kolhapur Cancer Centre
Kolhāpur, Maharashtra, 416234, India
Tata Memorial Hospital
Mumbai, Maharashtra, 400013, India
Government Medical College
Nagpur, Maharashtra, 440003, India
Shalinitai Meghe Medical College and Hospital
Nagpur, Maharashtra, 441110, India
HCG Manavata Cancer Centre
Nashik, Maharashtra, 422002, India
Chopda Medicare & Research Centre pvt. Ltd
Nashik, Maharashtra, 422005, India
Apex Wellness Hospital
Nashik, Maharashtra, 422009, India
Sahyadri Speciality Hospital
Pune, Maharashtra, 411004, India
Sahyadri Super Specialty Hospital Hadapsar
Pune, Maharashtra, 411028, India
Lokmanya Holistic Cancer Care and Research Center (LMRC)
Pune, Maharashtra, 411033, India
Christian Medical College-Ranipet Campus
Ratnagiri Kilminnal, Tamil Nadu, 632517, India
King George Medical University (KGMU)
Lucknow, Uttar Pradesh, 226003, India
Institute of Post Graduate Medical Education and Research (IPGMER) and SSKM Hospital
Kolkata, West Bengal, 700020, India
Cork University Hospital
Cork, T12 DC4A, Ireland
Bon Secours Hospital
Cork, T12 DV56, Ireland
St Vincents University Hospital
Dublin, D04 T6F4, Ireland
Beaumont Hospital
Dublin, D09 V2N0, Ireland
Galway University Hospital
Galway, H91 YR71, Ireland
Mid- Western Regional Hospital Limerick
Limerick, V94 F858, Ireland
Waterford Regional Hospital
Waterford, X91 ER8E, Ireland
Shamir Medical Center Assaf Harofeh
Beer Jacob, 0073100, Israel
Soroka University Medical Centre
Beersheba, 84101, Israel
Sheba Medical Center - PPDS
Ramat Gan, 52621, Israel
Tel-Aviv Sourasky Medical Center
Tel Aviv, 6423906, Israel
Azienda Ospedaliera di Rilievo Nazionale e di Alta Specialita San Giuseppe Moscati
Avellino, Campania, 83100, Italy
Istituto Nazionale per lo Studio e la Cura dei Tumori Fondazione G. Pascale
Naples, Campania, 80131, Italy
IRCCS Azienda Ospedaliero Universitaria di Bologna
Bologna, Emilia-Romagna, 40138, Italy
Istituto Scientifico Romagnolo Per Lo Studio E La Cura Dei Tumori IRST - PPDS
Meldola, Emilia-Romagna, 47014, Italy
Arcispedale Santa Maria Nuova
Reggio Emilia, Emilia-Romagna, 42100, Italy
Fondazione Policlinico Universitario A Gemelli
Roma, Emilia-Romagna, 00168, Italy
Ospedale San Raffaele S.r.l. - PPDS
Milan, Lombardy, 20132, Italy
Istituto Nazionale Tumori Regina Elena
Milan, Lombardy, 20133, Italy
ASST Grande Ospedale Metropolitano Niguarda - Presidio Ospedaliero Ospedale Niguarda Ca' Granda
Milan, Lombardy, 20162, Italy
Istituto Clinico Humanitas
Rozzano (MI), Lombardy, 20089, Italy
Ospedale San Giuseppe
Empoli, Tuscany, 50053, Italy
Azienda Usl Toscana nord ovest - Ospedali Riuniti di Livorno
Livorno, Tuscany, 57123, Italy
Azienda Ospedaliero Universitaria Pisana
Pisa, Tuscany, 56126, Italy
Fukushima Medical University Hospital
Fukushima, 960-1295, Japan
Hiroshima University Hospital
Hiroshima, 734-8551, Japan
Social Medical Corporation Hakuaikai Sagara Hospital
Kagoshima, 892-0833, Japan
Tokai University Hospital
Kanagawa, 259-1193, Japan
Saitama Cancer Center
Kitaadachi-gun, 362-0806, Japan
Kumamoto University Hospital
Kumamoto-Shi Chuo-Ku, 860-8555, Japan
Nahanishi Clinic
Naha, 901-0154, Japan
National Hospital Organization Osaka National Hospital
Osaka, 540-0006, Japan
Osaka International Cancer Institute
Osaka, 541-8567, Japan
National Hospital Organization Hokkaido Cancer Center
Sapporo, 003-0804, Japan
St. Luke's International Hospital
Tokyo, 104-0044, Japan
The Cancer Institute Hospital of Japanese Foundation For Cancer Research
Tokyo, 135-8550, Japan
International Cancer Institute (ICI)
Eldoret, 30100, Kenya
The Aga Khan University-Kenya.
Nairobi, 00100, Kenya
Pauls Stradins Clinical University Hospital
R?ga, LV-1002, Latvia
Hospital Kuala Lumpur
Kuala Lumpur, FED. Territory of Kuala Lumpur, 50586, Malaysia
University Malaya Medical Centre
Kuala Lumpur, FED. Territory of Kuala Lumpur, 59100, Malaysia
National Cancer Institute IKN
Putrajaya, Federal Territory of Putrajaya, 62250, Malaysia
Pantai Hospital Sungai Petani
Sungai Petani, Kedah, 08000, Malaysia
Hospital Pulau Pinang
George Town, Pulau Pinang, 10990, Malaysia
Sarawak General Hospital
Buzia?, Sarawak, 305100, Malaysia
Beacon International Specialist Centre
Petaling Jaya, Selangor, Selangor, 46050, Malaysia
Centro de Investigación en Artritis y Osteoporosis - PPDS
Mexicali, Estado de Baja California, 21200, Mexico
Dr. José Luis González Trujillo
León, Guanajuato, 37000, Mexico
Hospital Civil Fray Antonio Alcalde
Guadalajara, Jalisco, 44280, Mexico
Health Pharma Professional Research
Mexico City, Mexico CITY (federal District), 03100, Mexico
Accelerium S. de R.L. de C.V.
Monterrey, Nuevo León, 64000, Mexico
Hospital Universitario Dr. Jose Eleuterio Gonzalez
Monterrey, Nuevo León, Mexico
Centro de Investigacion Clinica de Oaxaca
Oaxaca City, Oaxaca, 68020, Mexico
Investigación Médica de Alta Especialidad
Querétaro City, Querétaro, 76000, Mexico
Neurociencias Estudios Clinicos S.C.
Culiacán, Sinaloa, 80020, Mexico
Merida | Investigacion Clinica
Mérida, Yucatán, 97125, Mexico
Centro de Investigacion Medica Aguascalientes
Aguascalientes, 20116, Mexico
Centro Oncologico Alianza XXI
México, Mexico
Oaxaca Site Management Organization
Oaxaca City, 68000, Mexico
Oncologica de Puebla S.A de C.V
Puebla City, CP 72530, Mexico
Oncológico Potosino
San Luis Potosí City, 78250, Mexico
Centro Hemato-Oncologico Privado CHOP
Toluca, 50080, Mexico
Catharina Hospital
Eindhoven, 5623 EJ, Netherlands
Hagaziekenhuis
The Hague, 2545 AA, Netherlands
Viecuri Medisch Centrum
Venlo, 5912 BL, Netherlands
PHI Clinical Hospital Dr Trifun Panovski Bitola
Bitola, 7000, North Macedonia
Acibadem Sistina Hospital
Skopje, 1000, North Macedonia
PHI University Clinic of Radiotherapy and Oncology
Skopje, 1000, North Macedonia
Clinica San Antonio;Investigaciones Trujillo S.A.C.
Trujillo, La Libertad, 13008, Peru
Hospital Nacional Daniel A Carrion
Bellavista, 7016, Peru
Hospital Militar Central
Jesus Maria, Lima 11, Peru
Hospital Central Fuerza Aerea Del Peru
Lima, 15046, Peru
Clínica Santa Beatriz
Lima, 15072, Peru
Oncologia S.A.C. - Instituto Peruano de Oncología & Radioterapia
Lima, 27, Peru
Oncosalud Sac
Lima, 41, Peru
Saint Louis University Hospital of Sacred Heart
Baguio City, Benguet, 2600, Philippines
University of Santo Tomas Hospital
Manila, National Capital Region, 1015, Philippines
Riverside Medical Center, Inc.
Bacolod City, Western Visayas (Region VI), 6100, Philippines
Baguio General Hospital and Medical Center
Baguio City, 2600, Philippines
Metro Davao Medical and Research Center
Davao City, 8000, Philippines
St. Paul's Hospital
Iloilo City, 5000, Philippines
Cardinal Santos Medical Center
Manila, 1503, Philippines
The Medical City
Pasig, 1605, Philippines
East Avenue Medical Center
Quezon City, 1101, Philippines
St. Luke's Medical Center - Quezon City
Quezon City, 1102, Philippines
Centrum Onkologii im. Prof. F. Lukaszczyka w Bydgoszczy
Bydgoszcz, 85-796, Poland
Szpital Morski Im. Pck
Gdynia, 81-519, Poland
Narodowy Instytut Onkologii im. M.Sk?odowskiej-Curie - Pa?stwowy Instytut Badawczy Oddzia? Gliwice
Gliwice, 44-101, Poland
Regionalny Szpital Specjalistyczny im. W. Bieganskiego
Grudziądz, 86-300, Poland
Narodowy Instytut Onkologii - Panstwowy Instytut Badawczy, Oddzia? w Krakowie
Krakow, 31-115, Poland
Centrum Terapii Wspolczesnej
Lodz, 90-338, Poland
Centrum Onkologii Ziemi LUBELSKIEJ im. Sw Jana z Dukli, I oddz. Chemioterapii
Lublin, 20-090, Poland
Centrum Medyczne Pratia
Poznan, 60-192, Poland
Narodowy Instytut Onkologii im. Marii Sk?odowskiej-Curie - Pa?stwowy Instytut Badawczy
Warsaw, 02-781, Poland
Unidade Local de Saude de Santa Maria, E.P.E. - Hospital de Santa Maria
Lisbon, Lisbon District, 1649-035, Portugal
Hospital Senhora da Oliveira ? Guimaraes, E.P.E
Guimarães, 4835-044, Portugal
Instituto Português de Oncologia de Lisboa Francisco Gentil, E.P.E.
Lisbon, 1050-034, Portugal
Champalimaud Cancer Center
Lisbon, 1400-038, Portugal
Hospital da Luz
Lisbon, 1500-650, Portugal
Hospital Beatriz Angelo
Loures, 2674-514, Portugal
Centro Hospitalar do Porto ? Hospital de Santo António
Porto, 4099-001, Portugal
Instituto Portugues de Oncologia Do Porto Francisco Gentil Epe
Porto, 4200-072, Portugal
Centro Hospitalar de Vila Nova de Gaia / Espinho E.P.E
Vila Nova de Gaia, 4434-502, Portugal
Centro Hospitalar Trás Os Montes E Alto Douro EPE
Vila Real, 5000-508, Portugal
Spitalul Clinic de Obstetrica si Ginecologie Filantropia
Bucure?ti, 011171, Romania
Prof Dr I Chiricuta Institute of Oncology
Cluj-Napoca, 400015, Romania
Medisprof SRL
Cluj-Napoca, 400641, Romania
Oncology Center Sf. Nectarie
Craiova, 200347, Romania
Onco Clinic Consult SA
Craiova, 200516, Romania
Institutul Regional de Oncologie Iasi
Iași, 707023, Romania
Timisoara Emergency County Clinical Hospital
Timi?oara, 300595, Romania
Institute for Oncology and Radiology of Serbia
Belgrade, 11000, Serbia
University Hospital Medical Center Bezanijska kosa
Belgrade, 11080, Serbia
Oncology Institute of Vojvodina
Kamenitz, 21204, Serbia
Health Center Kladovo
Kladovo, 19320, Serbia
General Hospital Djordje Joanovic - Zrenjanin
Zrenjanin, 23000, Serbia
Narodny onkologicky ustav
Bratislava, 833 10, Slovakia
Vychodoslovensky onkologicky ustav
Košice, 040 01, Slovakia
Institute of Oncology Ljubljana
Ljubljana, 1000, Slovenia
Cape Town Oncology Trials
Cape Town, 7570, South Africa
Cancercare Rondebosch Oncology
Cape Town, 7700, South Africa
Sandton Oncology Medical Group (Pty) Ltd
City of Johannesburg, 2196, South Africa
Excellentis Clinical Trial Consultants
George, 6530, South Africa
Medical Oncology Centre of Rosebank
Johannesburg, 2196, South Africa
Langenhoven Drive Oncology Centre
Port Elizabeth, 6045, South Africa
Eastleigh Breast Care Centre
Pretoria, 0081, South Africa
Soon Chun Hyang University Cheonan Hospital
Cheonan-si, Chungcheongnam-do, 330721, South Korea
Chungbuk National University Hospital
Cheongju-si, 361-711, South Korea
Yonsei University Wonju Severance Christian Hospital
Gangwon-do, 26426, South Korea
National Cancer Centre
Gyeonggi-do, 10408, South Korea
CHA Bundang Medical Center
Gyeonggi-do, 13496, South Korea
Inha University Hospital
Incheon, 22332, South Korea
Gachon University Gil Medical Center
Namdong-Gu, 21565, South Korea
Korea University Anam Hospital
Seongbuk-Gu, 02841, South Korea
Seoul National University Bundang Hospital
Seongnam, 13620, South Korea
Seoul National University Hospital
Seoul, 03080, South Korea
Asan Medical Center - PPDS
Seoul, 05505, South Korea
Gangnam Severance Hospital, Yonsei University Health System
Seoul, 06273, South Korea
Korea University Guro Hospital
Seoul, 08308, South Korea
Severance Hospital, Yonsei University Health System
Seoul, 3722, South Korea
The Catholic University of Korea Seoul St. Mary?s Hospital
Seoul, 6591, South Korea
Samsung Medical Center - PPDS
Seoul, South Korea
Ulsan University Hosiptal
Songpa-Gu, 05505, South Korea
Ajou University Hospital
Suwon, 443-721, South Korea
Hospital General Universitario de Elche
Elche, Alicante, 03203, Spain
Hospital Son Llatzer
Palma de Mallorca, Balearic Islands, 07198, Spain
ICO Badalona-H.U. Germans Trias i Pujol
Badalona, Barcelona, 08916, Spain
ALTHAIA Xarxa Assistencial de Manresa
Manresa, Barcelona, 08243, Spain
Corporacio Sanitaria Parc Tauli
Sabadell, Barcelona, 08208, Spain
Hospital HM Nuestra Señora de la Esperanza
Santiago de Compostela, Burgos, 15705, Spain
Hospital de Jerez
Jerez de la Frontera, Cadiz, 11407, Spain
Consorcio Hospitalario Provincial de Castellon
Castellon de LA Plana/castello de LA Plana, Castellon, 12002, Spain
Hospital Universitario de Donostia
Donostia / San Sebastian, Guipuzcoa, 20080, Spain
Hospital Universitario A Coruña
A Coruña, LA Coruna, 15006, Spain
CHUS H Clinico U de Santiago
Santiago de Compostela, LA Coruna, 15706, Spain
Hospital Universitario Insular de Gran Canaria
Las Palmas de Gran Canaria, LAS Palmas, 35016, Spain
Hospital Universitari Arnau de Vilanova
Lleida, Lerida, 25198, Spain
Hospital Universitario Fundación Alcorcón
Alcorcón, Madrid, 28922, Spain
Complejo Hospitalario de Navarra
Pamplona, Navarre, 31008, Spain
CHUVI ? H.U. Alvaro Cunqueiro
Vigo, Pontevedra, 36312, Spain
Hospital Nuestra Senora de Valme
Seville, Sevilla, 41014, Spain
Hospital Universitario Virgen Macarena
Seville, Sevilla, 41071, Spain
Hospital Universitari Sant Joan de Reus
Reus, Tarragona, 43204, Spain
Hospital Universitario de Canarias
S. Cristobal de La Laguna, Tenerife, 38320, Spain
Hospital Universitario Basurto
Bilbao, Vizcaya, 48013, Spain
Complejo Hospitalario Universitario de Albacete
Albacete, 2006, Spain
Hospital General Universitario de Alicante
Alicante, 03010, Spain
Hospital Universitario San Juan
Alicante, 03550, Spain
Hospital Nuestra Señora de Sonsoles
Ávila, 05004, Spain
Hospital del Mar
Barcelona, 08003, Spain
Clinica Tres Torres
Barcelona, 08017, Spain
Hospital Universitario Quiron Dexeus
Barcelona, 08028, Spain
Hospital Clinic de Barcelona
Barcelona, 08036, Spain
Hospital de la Santa Creu i Sant Pau
Barcelona, 8041, Spain
Hospital Puerta del Mar
Cadiz, 11009, Spain
Hospital de San Pedro de Alcantara
Cáceres, 10003, Spain
Hospital General Universitario Reina Sofia
Córdoba, 14004, Spain
Institut Catala d'Oncologia Girona
Girona, 17007, Spain
Hospital Universitario Clínico San Cecilio
Granada, 18007, Spain
Hospital Universitario Virgen de Las Nieves
Granada, 18012, Spain
Hospital Universitario Juan Ramon Jimenez
Huelva, 21005, Spain
Hospital Universitario de Jaen
Jaén, 23007, Spain
Hospital General Universitario Gregorio Marañon
Madrid, 28007, Spain
IOB Madrid Institute of Oncology Hospital Beata Maria Ana de Jesus
Madrid, 28007, Spain
Hospital Universitario La Paz
Madrid, 280146, Spain
Clinica Universidad Navarra
Madrid, 28027, Spain
Hospital Universitario Infanta Leonor
Madrid, 28031, Spain
MD Anderson Cancer Center Madrid ? Espana
Madrid, 28033, Spain
Hospital Universitario Ramon y Cajal
Madrid, 28034, Spain
Hospital Clinico San Carlos
Madrid, 28040, Spain
Hospital Universitario Fundacion Jimenez Diaz.
Madrid, 28040, Spain
Hospital Universitario 12 De Octubre
Madrid, 28041, Spain
Hospital Universitario HM Sanchinarro ? CIOCC
Madrid, 28050, Spain
Hospital Universitario Puerta de Hierro - Majadahonda
Madrid, 28222, Spain
Hospital Universitario de Fuenlabrada
Madrid, 28942, Spain
Hospital Universitario Virgen de la Victoria
Málaga, 29010, Spain
Hospital General Universitario Morales Meseguer
Murcia, 30008, Spain
Hospital Universitario Virgen de La Arrixaca
Murcia, 30120, Spain
Hospital Universitario Son Espases
Palma de Mallorca, 07120, Spain
Hospital Universitario Virgen del Rocío
Seville, 41013, Spain
Fundacion Instituto Valenciano de Oncologia (IVO)
Valencia, 46009, Spain
Hospital Clinico Universitario de Valencia
Valencia, 46010, Spain
Consorcio Hospital General Universitario de Valencia
Valencia, 46014, Spain
Hospital Universitari i Politecnic La Fe de Valencia
Valencia, 46026, Spain
Hospital Clinico Universitario de Valladolid
Valladolid, 47005, Spain
Hospital Universitario Miguel Servet
Zaragoza, 50009, Spain
Länssjukhuset Ryhov
Jönköping, 553 05, Sweden
Södersjukhuset
Stockholm, 11883, Sweden
Sundsvalls sjukhus
Sundsvall, 851 86, Sweden
Akademiska Sjukhuset
Uppsala, 751 85, Sweden
Västmanlands sjukhus Västerås
Västerås, 721 89, Sweden
Brust-Zentrum Zürich AG Seefeldstrasse 214 Zürich
Zurich, Zürich (de), 8008, Switzerland
Tumorzentrum Aarau
Aarau, 5000, Switzerland
Kantonsspital Baden
Baden, 5404, Switzerland
Universitätsspital Basel
Basel, 4031, Switzerland
Universitätsspital Bern
Bern, 3010, Switzerland
Kantonsspital Graubünden KSGR
Chur, 7000, Switzerland
Luzerner Kantonsspital LUKS
Lucerne, 6000, Switzerland
Hirslanden Klinik St. Anna
Lucerne, 6006, Switzerland
Kantonsspital St. Gallen
Sankt Gallen, 9007, Switzerland
Spital STS AG Thun - Berner Oberland
Thun, 3600, Switzerland
Kantonsspital Winterthur Medizin Pneumologie
Winterthur, 8400, Switzerland
Changhua Christian Medical Foundation Changhua Christian Hospital
Changhua County, 50006, Taiwan
Hsin-Chu Branch of National Taiwan University Hospital
Hsinchu, 300, Taiwan
Kaohsiung Medical University Chung-Ho Memorial Hospital
Kaohsiung City, 807, Taiwan
Taipei Medical University Shuang Ho Hospital
New Taipei City, 23561, Taiwan
China Medical University Hospital
Taichung, 40447, Taiwan
National Cheng Kung University Hospital
Tainan, 70457, Taiwan
Chi Mei Medical Cente
Tainan, 71044, Taiwan
National Taiwan University Hospital
Taipei, 100, Taiwan
Mackay Memorial Hospital - Taipei Branch
Taipei, 10449, Taiwan
Taipei Veterans General Hospital
Taipei, 11217, Taiwan
Koo Foundation Sun Yat-Sen Cancer Center
Taipei, 112, Taiwan
Chang Gung Memorial Hospital - Linkou
Taoyuan, 33305, Taiwan
Taichung Veterans General Hospital
Xitun Dist., 40705, Taiwan
Chulalongkorn Hospital
Bangkok, 10330, Thailand
Ramathibodi Hospital
Bangkok, 10400, Thailand
Siriraj Hospital, Mahidol University
Bangkok Noi, 10700, Thailand
Baskent Universitesi - Adana Uygulama Ve Arastirma Merkezi
Sariçam, Adana, 01250, Turkey (Türkiye)
Hacettepe Universitesi Tip Fakultesi Hastanesi
Ankara, 06100, Turkey (Türkiye)
Ankara City Hospital
Ankara, 06800, Turkey (Türkiye)
Akdeniz University Medical Faculty
Antalya, 07059, Turkey (Türkiye)
Trakya University Medical Faculty
Edirne, 22030, Turkey (Türkiye)
T.C. Saglik Bakanligi Goztepe Prof. Dr. Suleyman Yalcin City Hospital
Istanbul, 34722, Turkey (Türkiye)
Izmir Medical Point Hospital
Izmir, 35101, Turkey (Türkiye)
Katip Celebi University- Izmir Ataturk Egitim ve Arastirma Hastanesi
Izmir, 35360, Turkey (Türkiye)
Kocaeli Universitesi Tip Fakultesi Arastirma ve Uygulama Hastanesi
Kocaeli, 41380, Turkey (Türkiye)
Ondokuz Mayis Universitesi Tip Fakultesi Hastanesi
Samsun, 55239, Turkey (Türkiye)
Ac?badem Adana Hospital, Oncology Department
Seyhan/Adana, 01130, Turkey (Türkiye)
Acibadem Altunizade Hospital
Üsküdar, 34662, Turkey (Türkiye)
Dr. Abdurrahman Yurtaslan Ankara Onkoloji Egitim ve Arastirma Hastanesi
Yen?mahalle, 06200, Turkey (Türkiye)
Uganda Cancer Institute
Kampala, 99999, Uganda
St Francis Hospital Nsambya
Kampala, Uganda
Communal Non-Profit Enterprise Chernihiv Medical Center of Modern Oncology of CRC
Chernihiv, KIEV Governorate, 14029, Ukraine
Clinic Verum Expert LLC
Kyiv, KIEV Governorate, 03039, Ukraine
Medical Clinical Research Center of Medical Center LLC Health Clinic
Vinnytsia, 21009, Ukraine
Leicester Royal Infirmary
Leicester, LE2 7LX, United Kingdom
University College London Hospitals
London, United Kingdom
Nottingham City Hospital
Nottingham, NG5 1PB, United Kingdom
Royal Preston Hospital
Preston, PR2 9HT, United Kingdom
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- STUDY DIRECTOR
Clinical Trials
Hoffmann-La Roche
Study Design
- Study Type
- interventional
- Phase
- phase 3
- Allocation
- RANDOMIZED
- Masking
- NONE
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- INDUSTRY
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
July 5, 2021
First Posted
July 14, 2021
Study Start
August 27, 2021
Primary Completion
August 8, 2025
Study Completion (Estimated)
January 1, 2035
Last Updated
February 20, 2026
Record last verified: 2026-02
Data Sharing
- IPD Sharing
- Will share
For eligible studies, qualified researchers may request access to individual patient level clinical data. See Roche's commitment to transparency of clinical study information here: https://go.roche.com/data\_sharing