Aerobic Exercise and Telomere Length in Patients With Heart Failure.
Effects of Aerobic Exercise on Telomere Length in Patients With Systolic Heart Failure: A Randomized Clinical Trial.
1 other identifier
interventional
24
1 country
1
Brief Summary
The present study will analyze and compare the chronic effects of aerobic exercise in subjects with systolic heart failure on telomere length.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for not_applicable heart-failure
Started Mar 2021
Shorter than P25 for not_applicable heart-failure
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
February 15, 2019
CompletedFirst Posted
Study publicly available on registry
February 27, 2019
CompletedStudy Start
First participant enrolled
March 1, 2021
CompletedPrimary Completion
Last participant's last visit for primary outcome
August 30, 2021
CompletedStudy Completion
Last participant's last visit for all outcomes
December 30, 2021
CompletedJanuary 11, 2021
January 1, 2021
6 months
February 15, 2019
January 8, 2021
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Biological Aging
Telomere Length
16 weeks
Secondary Outcomes (4)
Aerobic Capacity
16 weeks
Echocardiography Variables
16 weeks
Endothelial Function
16 weeks
SSWS
16 weeks
Study Arms (2)
MIAT
EXPERIMENTALComposite of the execution of moderated-intensity aerobic training (MIAT) twice week.
Control
EXPERIMENTALConsisting of two session per week of different activities, such as body relaxation, low-intesity/volume of aerobic exercise to mimic sham group.
Interventions
Eligibility Criteria
You may qualify if:
- Primary diagnosis of HF with ejection fraction \<40%;
- Clinically stable patients with at least three months on optimal HF treatment;
- Age between 50 and 80 years;
- New York Heart Association (NYHA) functional class II to III;
- No contraindications to participate in an exercise program;
- Mentally able to understand instructions during the study.
You may not qualify if:
- Severe valve disease;
- Peripheral artery disease with symptoms of intermittent claudication;
- Uncontrolled hypertension;
- Drug or alcohol abuse;
- Cognitive and/or osteomyoarticular conditions that prevent exercise;
- Logistical impossibility of attending the hospital intervention;
- Engaging in supervised physical exercise in the past three months;
- Do not complete the run-in period.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Hospital de Clínicas de Porto Alegre
Porto Alegre, Rio Grande do Sul, 90035903, Brazil
Related Publications (1)
Franzoni LT, Garcia EL, Motta SB, Ahner MM, Bertoletti OA, Saffi MAL, da Silveira AD, Pereira AA, Pereira AH, Danzmann LC, Stein R. Aerobic exercise and telomere length in patients with systolic heart failure: protocol study for a randomized controlled trial. Trials. 2022 Apr 11;23(1):283. doi: 10.1186/s13063-022-06257-1.
PMID: 35410445DERIVED
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Ricardo Stein, PhD
Hospital de Clínicas de Porto Alegre
Central Study Contacts
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- DOUBLE
- Who Masked
- INVESTIGATOR, OUTCOMES ASSESSOR
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
February 15, 2019
First Posted
February 27, 2019
Study Start
March 1, 2021
Primary Completion
August 30, 2021
Study Completion
December 30, 2021
Last Updated
January 11, 2021
Record last verified: 2021-01