Alveolar Ridge Preservation Techniques After Tooth Extraction

NCT04934813 | Completed

• 1 other identifier: Ethical committe No324
• Study Type: interventional
• Target: 36
• Locations: 1 country
• Sites: 1

Brief Summary

The aim of the present randomized controlled trial (RCT) was to evaluate the efficacy of different alveolar ridge preservation (ARP) techniques on hard tissue dimensional alterations after tooth extraction, based on clinical measurements.

Conditions

Alveolar Bone Loss

Outcome Measures

Primary Outcomes (2)

• Vertical dimensional alterations of the alveolar ridge, after tooth extraction.

  Assessment of the alteration of the alveolar ridge height after different alveolar ridge preservation techniques, based on clinical measurements. Clinical measurements were carried out immediately after tooth extraction and 4 months later. Distances in those clinical measurements were recorded in 0.1 mm increments, using a digital calliper (Logilink digital caliper WZ0031).

  4 months

• Horizontal dimensional alterations of the alveolar ridge, after tooth extraction.

  Assessment of the alteration of the alveolar ridge width after different alveolar ridge preservation techniques, based on clinical measurements. Clinical measurements were carried out immediately after tooth extraction and 4 months later. Distances in those clinical measurements were recorded in 0.1 mm increments, using a digital calliper (Logilink digital caliper WZ0031).

  4 months

Study Arms (4)

Alveolar ridge preservation with particulated allograft covered with collagen sponge.

EXPERIMENTAL

Alveolar ridge preservation after tooth extraction. Freeze-dried bone allograft (FDBA) was applied in the socket immediatelly after tooth extraction and it was covered with collagen sponge (CS).

Other: Alveolar ridge preservation

Alveolar ridge preservation with particulated allograft covered with autogenous soft tissue punch

EXPERIMENTAL

Alveolar ridge preservation after tooth extraction. Freeze-dried bone allograft (FDBA) was applied in the socket immediatelly after tooth extraction and it was covered with free gingival graft (FGG).

Other: Alveolar ridge preservation

Alveolar ridge preservation with particulated xenograft covered with autogenous soft tissue punch

EXPERIMENTAL

Alveolar ridge preservation after tooth extraction. Demineralized bovine bone mineral xenograft (DBBM) was applied in the socket immediatelly after tooth extraction and it was covered with free gingival graft (FGG).

Other: Alveolar ridge preservation

Alveolar ridge preservation without bone grafting covered with socket sealing mean

EXPERIMENTAL

Alveolar ridge preservation after tooth extraction. No bone graft was applied and the socket was covered with free gingival graft (FGG).

Other: Alveolar ridge preservation

Interventions

Alveolar ridge preservation OTHER

application of different bone graft and sealing means after tooth extraction

Alveolar ridge preservation with particulated allograft covered with autogenous soft tissue punch; Alveolar ridge preservation with particulated allograft covered with collagen sponge.; Alveolar ridge preservation with particulated xenograft covered with autogenous soft tissue punch; Alveolar ridge preservation without bone grafting covered with socket sealing mean

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• systematically healthy patients
• non-smokers
• no use of antibiotics for the last 3 months
• presence of a non-restorable single-rooted tooth in the maxilla.

You may not qualify if:

• Patients were excluded when a bony wall loss of more than 50% was verified for the socket after the extraction

Sponsors & Collaborators

• National and Kapodistrian University of Athens: lead

Study Sites (1)

National and Kapodistrian University

Athens, Attica, 11527, Greece

Location

Related Publications (1)

• El-Sioufi I, Oikonomou I, Koletsi D, Bobetsis YA, Madianos PN, Vassilopoulos S. Clinical evaluation of different alveolar ridge preservation techniques after tooth extraction: a randomized clinical trial. Clin Oral Investig. 2023 Aug;27(8):4471-4480. doi: 10.1007/s00784-023-05068-1. Epub 2023 May 25.

  PMID: 37227497 DERIVED

MeSH Terms

Conditions

Alveolar Bone Loss

Condition Hierarchy (Ancestors)

Bone Resorption; Bone Diseases; Musculoskeletal Diseases; Periodontal Atrophy; Periodontal Diseases; Mouth Diseases; Stomatognathic Diseases

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: TRIPLE
• Who Masked: PARTICIPANT, INVESTIGATOR, OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal investigator, Iosif El-Sioufi, Master of Science in Periodontology, School of Dentistry, National and Kapodistrian University of Athens

Study Record Dates

• First Submitted: June 4, 2021
• First Posted: June 22, 2021
• Study Start: March 1, 2017
• Primary Completion: December 20, 2019
• Study Completion: June 25, 2020
• Last Updated: June 22, 2021

Record last verified: 2021-06

Data Sharing

• IPD Sharing: Will not share

Locations

GR (1)