Association Between Balance and the Integrity of Cerebellar White Matter Tracts in a Healthy Population

NCT04934319 | Completed DMC

• 1 other identifier: SC20FISI0152
• Study Type: interventional
• Target: 22
• Locations: 1 country
• Sites: 1

Brief Summary

The cerebellum is involved in regulating balance and walking and plays a crucial role in the locomotor adaptation and learning processes. This study aims to investigate the association between balance and the integrity of the cerebellar white matter tracts in a healthy population. Healthy participants will undergo four weeks of balance training. The investigators will analyze changes in the microstructural integrity of the cerebellar white matter tract before and after four weeks of balance training.

Conditions

Balance; Cerebellum

Keywords

Balance; Cerebellum; White matter tract; Diffusion Tensor Imaging

Outcome Measures

Primary Outcomes (2)

• Fractional anisotropy of the cerebellar white matter tracts

  Measurement of the change of DTI-derived parameters before and after balance and proprioceptive training 1. Tracts of interest * Corticospinal tract (CST) * Cortico-ponto-cerebellar tract (CPCT) * Dentato-rubro-thalamo-cortical tract (DRTCT) * Dorsal spinocerebellar tract (DSCT) 2. Measurement of DTI-derived parameter * Fractional anisotropy (FA) values of the CST, CPCT, DRTCT, and DSCT 3. Units and scoring of the Measurement * FA * No unit. * The measurement ranges from 0 to 1 * Higher scores indicate better microstructural integrity.

  Four weeks

• Community Balance & Mobility Scale

  Performance measure before and after balance and proprioceptive training 1. Measurement * 13 domain * Unilateral stance, Tandem walking, 180° tandem pivot, Lateral foot scooting, Hopping forward, Crouch and walk, Lateral dodging, Walking \& looking, Running with controlled stop, Forward to backward walking, Walk look and carry, Descending stairs, Step-ups x 1 step 2. Scoring of the Measurement * No units. * The measurement ranges from 0 to 96 * Higher scores indicate better postural balance and mobility.

  Four weeks

Secondary Outcomes (2)

• Mean diffusivity of the cerebellar white matter tracts

  Four weeks

• Tract volume of the cerebellar white matter tracts

  Four weeks

Study Arms (1)

Balance training

EXPERIMENTAL

A single training group

Behavioral: Balance and Proprioceptive Training

Interventions

Balance and Proprioceptive Training BEHAVIORAL

* Step-by-step training (5 levels) * 30 minute per training * 3 times per week * Four weeks

Balance training

Eligibility Criteria

• Age: 20 Years - 74 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Mini-mental state examination \>=26
• Independent outdoor ambulator

You may not qualify if:

• Men/women with any metal implants in their body
• A prior history of psychopathology or a neurological disorders
• A prior history of osteoporosis, advanced osteoarthritis (K-L grade \>=3), surgical history of hip or knee arthroplasty
• If any structural abnormalities are detected on their scan

Sponsors & Collaborators

• The Catholic University of Korea: lead

Study Sites (1)

Yeouido St. Mary's Hospital

Seoul, Yeongdeungpo-gu, 07345, South Korea

Location

Related Publications (3)

• Kim JS, Kim SH, Lim SH, Im S, Hong BY, Oh J, Kim Y. Degeneration of the Inferior Cerebellar Peduncle After Middle Cerebral Artery Stroke: Another Perspective on Crossed Cerebellar Diaschisis. Stroke. 2019 Oct;50(10):2700-2707. doi: 10.1161/STROKEAHA.119.025723. Epub 2019 Aug 26.

  PMID: 31446886 BACKGROUND

• Kim Y, Kim SH, Kim JS, Hong BY. Modification of Cerebellar Afferent Pathway in the Subacute Phase of Stroke. J Stroke Cerebrovasc Dis. 2018 Sep;27(9):2445-2452. doi: 10.1016/j.jstrokecerebrovasdis.2018.04.039. Epub 2018 May 22.

  PMID: 29801815 BACKGROUND

• Kim Y, Im S, Kim SH, Park GY. Laterality of cerebellar afferent and efferent pathways in a healthy right-handed population: A diffusion tensor imaging study. J Neurosci Res. 2019 May;97(5):582-596. doi: 10.1002/jnr.24378. Epub 2018 Dec 24.

  PMID: 30582195 BACKGROUND

Study Officials

• Youngkook Kim, Ph.D.

  Yeouido St. Mary's Hospital, College of Medicine, The Catholic University of Korea

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor

Study Record Dates

• First Submitted: June 7, 2021
• First Posted: June 22, 2021
• Study Start: May 24, 2021
• Primary Completion: October 30, 2021
• Study Completion: December 31, 2021
• Last Updated: June 13, 2022

Record last verified: 2022-06

Data Sharing

• IPD Sharing: Will not share

Locations

KR (1)