Work of Breathing Under Extreme Hypercapnia Induced by Ventilation Insufficiency

NCT04835545 | Unknown

• 1 other identifier: DP-2021-Nemec
• Study Type: interventional
• Target: 13
• Locations: 1 country
• Sites: 1

Brief Summary

The aim of the study is to investigate Work of Breathing of a person in simulated avalanche snow and consequent use of the measured data for judging which one of three simulated scenarios are alike while increasing hypercapnia in the simulated avalanche snow.

Conditions

Accident Caused by Snow Avalanche

Keywords

snow; avalanche; hypercapnia; work of breathing

Outcome Measures

Primary Outcomes (1)

• The length of breathing

  Time to termination of the breathing experiment due to the decision of the tested subject, or determined by high end-tidal carbon dioxide value or by the order by the clinician assessing the health status of the subjects.

  Continuously within up to 7 minute interval from the beginning of the breathing experiment

Study Arms (3)

Wet Perlite, 2L air pocket

EXPERIMENTAL

Breathing in the simulated avalanche snow. Breathing into model of wet perlite with 2L air pocket

Other: extreme hypercapnia induced by ventilation insufficiency

Wet Perlite 2L air pocket with resistance compensation

EXPERIMENTAL

Breathing in the simulated avalanche snow. Breathing into model of wet perlite 2L air pocket with resistance compensation

Other: extreme hypercapnia induced by ventilation insufficiency

Wet Perlite, no air pocket

EXPERIMENTAL

Breathing in the simulated avalanche snow. Breathing into model of wet perlite with no air pocket

Other: extreme hypercapnia induced by ventilation insufficiency

Interventions

extreme hypercapnia induced by ventilation insufficiency OTHER

extreme hypercapnia

Wet Perlite 2L air pocket with resistance compensation; Wet Perlite, 2L air pocket; Wet Perlite, no air pocket

Eligibility Criteria

• Age: 18 Years - 30 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• healthy and fit volunteers, classified as The American Society of Anesthesiologists class I
• without a smoking history

You may not qualify if:

• Tiffeneau Index less than 0.70
• any cardiovascular or respiratory condition

Sponsors & Collaborators

• Czech Technical University in Prague: lead

Study Sites (1)

Czech Technical University, Faculty of Biomedical Engineering

Kladno, 272 01, Czechia

Location

Related Publications (1)

• Roubik K, Sieger L, Sykora K. Work of Breathing into Snow in the Presence versus Absence of an Artificial Air Pocket Affects Hypoxia and Hypercapnia of a Victim Covered with Avalanche Snow: A Randomized Double Blind Crossover Study. PLoS One. 2015 Dec 14;10(12):e0144332. doi: 10.1371/journal.pone.0144332. eCollection 2015.

  PMID: 26666523 BACKGROUND

MeSH Terms

Conditions

Hypercapnia

Condition Hierarchy (Ancestors)

Signs and Symptoms, Respiratory; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Officials

• Karel Roubík, PhD

  Czech Technical University in Prague, FBMI

  STUDY DIRECTOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Purpose: BASIC SCIENCE
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: April 5, 2021
• First Posted: April 8, 2021
• Study Start: March 29, 2021
• Primary Completion: April 1, 2024
• Study Completion: April 1, 2024
• Last Updated: July 22, 2022

Record last verified: 2022-07

Data Sharing

• IPD Sharing: Will not share

Locations

CZ (1)