Snow Properties and Its Modeling for Studying Gas Exchange Under the Simulated Avalanche Snow

NCT03413878 | Unknown

• 1 other identifier: VentRes-2018-01-KR
• Study Type: interventional
• Target: 45
• Locations: 1 country
• Sites: 2

Brief Summary

The aim of the study is to investigate respiratory parameters of a person in the simulated avalanche snow and consequent use of the measured data for development of a mathematical-physical model of breathing during increasing hypercapnia in the avalanche.

Conditions

Accident Caused by Snow Avalanche

Keywords

snow; avalanche; hypercapnia; work of breathing

Outcome Measures

Primary Outcomes (1)

• The length of breathing

  Time to termination of the breathing experiment due to the decision of the tested subject, or determined by high end-tidal carbon dioxide value or by the order by the clinician assessing the health status of the subjects.

  Continuously within 30 minute interval from the beginning of the breathing experiment

Study Arms (4)

Wet snow/Small air pocket

EXPERIMENTAL

Breathing in the simulated avalanche snow. Breathing into model of wet avalanche snow with a small air pocket

Other: Breathing in the simulated avalanche snow

Dry snow/Small air pocket

EXPERIMENTAL

Breathing in the simulated avalanche snow. Breathing into model of dry avalanche snow with a small air pocket

Other: Breathing in the simulated avalanche snow

Wet snow/Large air pocket

EXPERIMENTAL

Breathing in the simulated avalanche snow. Breathing into model of wet avalanche snow with a large air pocket

Other: Breathing in the simulated avalanche snow

Dry snow/Large air pocket

EXPERIMENTAL

Breathing in the simulated avalanche snow. Breathing into model of dry avalanche snow with a large air pocket

Other: Breathing in the simulated avalanche snow

Interventions

Breathing in the simulated avalanche snow OTHER

Breathing in the simulated wet or dry avalanche snow with a small or large air pocket

Dry snow/Large air pocket; Dry snow/Small air pocket; Wet snow/Large air pocket; Wet snow/Small air pocket

Eligibility Criteria

• Age: 18 Years - 50 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• healthy and fit volunteers, classified as The American Society of Anesthesiologists class I
• without a smoking history

You may not qualify if:

• Tiffeneau Index less than 0.70
• any cardiovascular or respiratory condition

Sponsors & Collaborators

• Czech Technical University in Prague: lead
• Charles University, Czech Republic: collaborator
• Ministry of Defence and Armed Forces of the Czech Republic: collaborator

Study Sites (2)

Czech Technical University, Faculty of Biomedical Engineering

Kladno, 272 01, Czechia

Location

Charles University, Czech Republic

Prague, 162 00, Czechia

Location

Related Publications (6)

• Brugger H, Sumann G, Meister R, Adler-Kastner L, Mair P, Gunga HC, Schobersberger W, Falk M. Hypoxia and hypercapnia during respiration into an artificial air pocket in snow: implications for avalanche survival. Resuscitation. 2003 Jul;58(1):81-8. doi: 10.1016/s0300-9572(03)00113-8.

  PMID: 12867313 BACKGROUND

• Bellani G, Patroniti N, Weismann D, Galbiati L, Curto F, Foti G, Pesenti A. Measurement of pressure-time product during spontaneous assisted breathing by rapid interrupter technique. Anesthesiology. 2007 Mar;106(3):484-90. doi: 10.1097/00000542-200703000-00012.

  PMID: 17325506 BACKGROUND

• Grissom CK, Radwin MI, Harmston CH, Hirshberg EL, Crowley TJ. Respiration during snow burial using an artificial air pocket. JAMA. 2000 May 3;283(17):2266-71. doi: 10.1001/jama.283.17.2266.

  PMID: 10807386 BACKGROUND

• Roubik K, Sieger L, Sykora K. Work of Breathing into Snow in the Presence versus Absence of an Artificial Air Pocket Affects Hypoxia and Hypercapnia of a Victim Covered with Avalanche Snow: A Randomized Double Blind Crossover Study. PLoS One. 2015 Dec 14;10(12):e0144332. doi: 10.1371/journal.pone.0144332. eCollection 2015.

  PMID: 26666523 BACKGROUND

• Strapazzon G, Paal P, Schweizer J, Falk M, Reuter B, Schenk K, Gatterer H, Grasegger K, Dal Cappello T, Malacrida S, Riess L, Brugger H. Effects of snow properties on humans breathing into an artificial air pocket - an experimental field study. Sci Rep. 2017 Dec 15;7(1):17675. doi: 10.1038/s41598-017-17960-4.

  PMID: 29247235 BACKGROUND

• Roubik K, Sykora K, Sieger L, Ort V, Horakova L, Walzel S. Perlite is a suitable model material for experiments investigating breathing in high density snow. Sci Rep. 2022 Feb 8;12(1):2070. doi: 10.1038/s41598-022-06015-y.

  PMID: 35136116 DERIVED

Related Links

• Work of Breathing into Snow in the Presence versus Absence of an Artificial Air Pocket Affects Hypoxia and Hypercapnia of a Victim Covered with Avalanche Snow: A Randomized Double Blind Crossover Study

MeSH Terms

Conditions

Hypercapnia

Interventions

Respiration

Condition Hierarchy (Ancestors)

Signs and Symptoms, Respiratory; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Respiratory Physiological Phenomena; Circulatory and Respiratory Physiological Phenomena

Study Officials

• Karel Roubik, PhD

  Czech Technical University in Prague, FBMI

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, INVESTIGATOR
• Purpose: BASIC SCIENCE
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: January 22, 2018
• First Posted: January 29, 2018
• Study Start: January 29, 2018
• Primary Completion: May 20, 2022
• Study Completion: May 20, 2022
• Last Updated: February 25, 2021

Record last verified: 2021-02

Locations

CZ (2)