Natural History and Patient Journey in Atrial Fibrillation: a Nationwide Linked Electronic Health Records Study of 5.6 Million Individuals.

NCT04786366 | Unknown

• 1 other identifier: ISAC17_205
• Study Type: observational
• Target: 5,601,803
• Locations: 0 countries
• Sites: N/A

Brief Summary

The trajectory of atrial fibrillation (AF) patients within the national health system and their recent temporal trends remains to be fully elucidated. To study the AF incidence, mortality and case-fatality, the investigators implemented a longitudinal cohort study with the linked electronic health records of 5.6 million population in the UK from 1998 to 2016 (CALIBER). A matched case-control study design was used to investigate the causes of hospitalization and death comparing individuals with and without incident AF.

Conditions

Atrial Fibrillation; Epidemiology

Keywords

Atrial Fibrillation; healthcare contacts; Electronic Health Records; epidemiology; comorbidity; health inequality

Outcome Measures

Primary Outcomes (2)

• Incidence of Atrial fibrillation

  AF incidence in the population

  Jan 1st 1998 - May 31st 2016

• Mortality of Atrial fibrillation

  Mortality among AF patients

  Jan 1st 1998 - May 31st 2016

Interventions

The study does not have an intervention, but observe the AF incidence of the UK disease-free population OTHER

The study does not have an intervention, but observe the AF incidence of the UK disease-free population.

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

The investigators implement two study designs, first a longitudinal cohort study to assess AF incidence and second a matched case-control study for mortality, cause of death and hospitalization. The investigators identify individuals aged 18 years or older and registered in the current primary care practice for at least one year. Individuals are excluded if they had a prior history of AF before study entry. For the nested case-control study, controls are matched to incident AF patients according to sex and age (10-year age strata).

You may qualify if:

• The investigators identify individuals aged 18 years or older and registered in the current primary care practice for at least one year.

You may not qualify if:

• Individuals are excluded if they had a prior history of AF before study entry.

Sponsors & Collaborators

• University College, London: lead

Related Publications (1)

• Chung SC, Schmit AF, Lip GYH, Providencia R. Electronic health record-wide association study for atrial fibrillation in a British cohort. Front Cardiovasc Med. 2023 Sep 28;10:1204892. doi: 10.3389/fcvm.2023.1204892. eCollection 2023.

  PMID: 37840952 DERIVED

MeSH Terms

Conditions

Atrial Fibrillation

Condition Hierarchy (Ancestors)

Arrhythmias, Cardiac; Heart Diseases; Cardiovascular Diseases; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: December 4, 2020
• First Posted: March 8, 2021
• Study Start: January 1, 1998
• Primary Completion: May 31, 2016
• Study Completion: June 30, 2021
• Last Updated: March 8, 2021

Record last verified: 2021-03