AtriCure Minimally Invasive Surgical Ablation for Atrial Fibrillation/RESTORE IIB

NCT00571779 | Withdrawn Phase 2

• 1 other identifier: CP2007-2
• Study Type: interventional
• Target: N/A
• Locations: 0 countries
• Sites: N/A

Brief Summary

Feasibility study arm to evaluate the safety of adding the left atrial linear connecting lesions of the Cox-Maze lesion set to the current RESTORE SR II IDE study procedure of performing pulmonary vein isolation, selected left atrial autonomic ganglionated plexi (GP) ablation, and optional left atrial appendage (LAA) excision/exclusion on a beating heart for patients with permanent or persistent Atrial Fibrillation (AF).

Conditions

Atrial Fibrillation

Outcome Measures

Primary Outcomes (2)

• Feasibility of performing the operation by demonstrating the ability to consistently isolate the left and right pulmonary veins and to confirm conduction block across the roof, anterior and LAA linear lesions.

• The primary safety endpoint will be determined by assessing the rate of serious adverse events.

Interventions

AtriCure Bipolar System DEVICE

Eligibility Criteria

• Age: 18 Years - 80 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Patient between 18 and 80 years of age
• Patient with documented symptomatic persistent or permanent AF and failure or intolerance of one or more Class I or Class III antiarrhythmic drugs.
• Persistent AF: AF that is not self-terminating or is terminated electrically or pharmacologically.
• Longstanding AF: Persistent AF of 12 months (or longer) duration.
• Permanent AF: Longstanding AF in which electrical or pharmacological cardioversion has failed or has not been attempted.
• Patient is willing and able to provide written informed consent.
• Patient has a life expectancy of at least 2 years.
• Patient is willing and able to attend the scheduled follow-up visits.

You may not qualify if:

• Prior cardiac catheter ablation for the treatment of arrhythmia within 4 months.
• Patients who refuse, but have not failed and can tolerate anti-arrhythmic medications
• Myocardial infarction within 8 weeks.
• Prior cardiac surgery.
• Patient requires cardiac surgery for treatment other than for AF.
• Class IV NYHA heart failure symptoms, unless due to uncontrolled AF
• Cerebrovascular accident within previous 6 months
• Known carotid artery stenosis greater than 80%
• Evidence of significant active infection
• Patient unable to undergo TEE
• Pregnant woman
• Patient requires anti-arrhythmic drug therapy for the treatment of ventricular arrhythmia
• Presence of thrombus in the left atrium
• Co-morbid condition that in the opinion of the investigator poses undue risk of general anesthesia or port access cardiac surgery
• Patient is enrolled in another cardiac clinical trial

Sponsors & Collaborators

• AtriCure, Inc.: lead

MeSH Terms

Conditions

Atrial Fibrillation

Condition Hierarchy (Ancestors)

Arrhythmias, Cardiac; Heart Diseases; Cardiovascular Diseases; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Design

• Study Type: interventional
• Phase: phase 2
• Sponsor Type: INDUSTRY

Study Record Dates

• First Submitted: December 10, 2007
• First Posted: December 12, 2007
• Last Updated: February 21, 2011

Record last verified: 2011-02