Impact of Core Performance on Functional Parameters in Multiple Sclerosis

NCT04750733 | Completed

• 1 other identifier: 59491012-604.01.0
• Study Type: observational
• Target: 50
• Locations: 1 country
• Sites: 1

Brief Summary

Optimal trunk control relies on somatosensory, motor and musculoskeletal integrity, which is often damaged in multiple sclerosis (MS). Researches on postural control in people with MS (PwMS) have revealed that reduced somatosensory conduction may adversely affect some functions. PwMS have increased postural sway in upright posture than healthy people. They move closer and slower when reaching out or taking a step. Trunk controls are weak and postural responses are delayed. The activation of core muscles is very important for an effective trunk control. Because the core region is considered a kinetic link that facilitates the transfer of torque and angular momentum between the upper and lower extremities during body movements. The decrease in core stability affects both trunk control and the quality of limb movements due to the kinetic chain in the body. There are a limited number of studies in the literature showing that core stability is reduced in PwMS. Our knowledge about the effects of this reduction on function in PwMS is very limited.

Conditions

Multiple Sclerosis

Keywords

Multiple sclerosis; core stability; postural control; isokinetic strength; physical capacity; fatigue

Outcome Measures

Primary Outcomes (4)

• Core strength

  Core strength will be evaluated within the scope of core assessment. Curl-Up and Modified Push-Up test will be used for the evaluation of core strength.

  Baseline

• Core endurance

  Core endurance will be evaluated within the scope of core assessment. Trunk flexor, extensor, lateral endurance and plank will be used in the evaluation of core endurance and recorded as seconds.

  Baseline

• Postural sway

  Postural sways will be evaluated with biodex balance system in different condition such as open eyes on firm and foam surface, closed eyes on firm and foam surface, double stance on firm and foam surface, tandem stance on firm and foam surface.

  Baseline

• İsokinetic strength

  Concentric isokinetic muscle strength of the knee flexor and extensor muscles will be evaluated with Biodex isokinetic dynamometer at angular velocities of 30,60 and 90°/s.

  Baseline

Secondary Outcomes (3)

• Physical capacity

  Baseline

• Mobility

  Baseline

• Fatigue

  Baseline

Study Arms (1)

Multiple Sclerosis

Ambulatory MS patients

Other: Assessment

Interventions

Assessment OTHER

Assessment of core strength and endurance, muscle strength, postural sway in different condition, physical capacity and fatigue

Multiple Sclerosis

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

People with MS followed in the Neurology Department of Bakirkoy Prof. Dr. Mazhar Osman Education and Research Hospital for Psychiatric and Neurological Diseases will be included.

You may qualify if:

• Being diagnosed with MS according to McDonald's criteria
• Disability level less than 6 according to EDSS (Expanded Disability Status Scale) score
• No attacks during the last 3 months
• Being an ambulatory
• Volunteering to participate in the study

You may not qualify if:

• Having orthopedic, neurological, psychological, etc. diseases that accompany MS and may affect treatment outcomes
• Doing regular sports
• Being involved in another physiotherapy and rehabilitation program related to MS

Sponsors & Collaborators

• Istanbul University - Cerrahpasa: lead

Study Sites (1)

Istanbul University-Cerrahpasa

Istanbul, 34147, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Multiple Sclerosis; Fatigue

Interventions

Restraint, Physical

Condition Hierarchy (Ancestors)

Demyelinating Autoimmune Diseases, CNS; Autoimmune Diseases of the Nervous System; Nervous System Diseases; Demyelinating Diseases; Autoimmune Diseases; Immune System Diseases; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Behavior Control; Therapeutics; Immobilization; Investigative Techniques

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Physiotherapist, Research Assistant

Study Record Dates

• First Submitted: February 7, 2021
• First Posted: February 11, 2021
• Study Start: February 20, 2021
• Primary Completion: July 1, 2022
• Study Completion: July 5, 2022
• Last Updated: July 8, 2022

Record last verified: 2022-07

Locations

TU (1)