Relationship of Position Sense With Gait and Balance in Patients With Multiple Sclerosis

NCT04547400 | Completed

• 1 other identifier: 2020-123
• Study Type: observational
• Target: 40
• Locations: 1 country
• Sites: 1

Brief Summary

Balance and gait disturbances are among the most common problems in patients with Multiple Sclerosis (MS). There is evidence of decreased foot sole sensation in MS patients. Studies conducted in healthy individuals have revealed the relationship between balance and foot sole sensation. These studies have demonstrated that sensory feedback from the cutaneous receptors of the foot sole plays an important role in maintaining balance. However, it is not yet known clearly to what extent the sensory impairment seen in MS patients affects balance and gait disorders. The aim of this study is to examine the relationship between lower extremity position sense and foot sole sense with gait and balance in MS patients.

Conditions

Multiple Sclerosis

Keywords

Multiple Sclerosis; Gait; Balance; Sensation

Outcome Measures

Primary Outcomes (2)

• Gait

  Gait parameters will be assessed via the G-Walk on two separate occasions. The G-Walk is a device that is worn on the waist via an elastic belt. The G-Walk is built with a triaxial accelerometer 16 bit/axes with multiple sensitivity, a triaxial magnetometer 13 bit and a triaxial gyroscope 16 bit/axes with multiple sensitivity. This hardware is capable of acquiring and transmitting data to a computer through a Bluetooth connection and at the end of each analysis an automatic report containing the gait assessment results is ready to be analyzed. Gait symmetry values of the right and left sides are obtained within this report. While the symmetry index ranges from 0 to 100, a value closer to 100 indicates that the gait is more symmetrica

  5 minutes

• Balance

  The Modified Sensory Organization Test, which is performed using computerized posturography, measures postural sway in response to 4 different sensory conditions is measured using a force platform.

  10 minutes

Secondary Outcomes (5)

• Light touch-pressure sensation

  10 minutes

• Vibration sensation

  10 minutes

• Two-point discrimination

  10 minutes

• position sensation of knee joint

  5 minutes

• Knee proprioception

  10 minutes

Study Arms (2)

Patients with Multiple Sclerosis

MS patients (EDSS: 0-5,5)

Other: assessment

Healthy group

Healthy individuals without chronic disease

Other: assessment

Interventions

assessment OTHER

Assessments of balance, gait, lower extremity position sense, and foot sole sense

Healthy group; Patients with Multiple Sclerosis

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

ambulatory sample

You may qualify if:

• years of age Having a diagnosis of "Multiple Sclerosis" by a specialist physician Relapse free in the last 3 mounts Having an ambulatory status (Expanded Disability Status Scale score ≤ 6 ) No diagnosis of depression

You may not qualify if:

• Any cardiovascular, orthopedic, visual, hearing and perception problems that may affect the results of the research

Sponsors & Collaborators

• Gazi University: lead

Study Sites (1)

Gazi University

Ankara, Turkey (Türkiye)

Location

Related Publications (4)

• Cattaneo D, Jonsdottir J. Sensory impairments in quiet standing in subjects with multiple sclerosis. Mult Scler. 2009 Jan;15(1):59-67. doi: 10.1177/1352458508096874. Epub 2008 Oct 9.

  PMID: 18845654 BACKGROUND

• Chung LH, Remelius JG, Van Emmerik RE, Kent-Braun JA. Leg power asymmetry and postural control in women with multiple sclerosis. Med Sci Sports Exerc. 2008 Oct;40(10):1717-24. doi: 10.1249/MSS.0b013e31817e32a3.

  PMID: 18799980 BACKGROUND

• Eils E, Behrens S, Mers O, Thorwesten L, Volker K, Rosenbaum D. Reduced plantar sensation causes a cautious walking pattern. Gait Posture. 2004 Aug;20(1):54-60. doi: 10.1016/S0966-6362(03)00095-X.

  PMID: 15196521 BACKGROUND

• Roll R, Kavounoudias A, Roll JP. Cutaneous afferents from human plantar sole contribute to body posture awareness. Neuroreport. 2002 Oct 28;13(15):1957-61. doi: 10.1097/00001756-200210280-00025.

  PMID: 12395099 BACKGROUND

MeSH Terms

Conditions

Multiple Sclerosis

Interventions

Restraint, Physical

Condition Hierarchy (Ancestors)

Demyelinating Autoimmune Diseases, CNS; Autoimmune Diseases of the Nervous System; Nervous System Diseases; Demyelinating Diseases; Autoimmune Diseases; Immune System Diseases

Intervention Hierarchy (Ancestors)

Behavior Control; Therapeutics; Immobilization; Investigative Techniques

Study Officials

• Cagla Ozkul

  Gazi University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: CROSS SECTIONAL
• Target Duration: 1 Day
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Research Assistant

Study Record Dates

• First Submitted: September 6, 2020
• First Posted: September 14, 2020
• Study Start: October 5, 2020
• Primary Completion: May 13, 2022
• Study Completion: May 13, 2022
• Last Updated: August 5, 2022

Record last verified: 2022-08

Locations

TU (1)