Clinical Factors Associated With Position Sense in Patients With Multiple Sclerosis

NCT04548297 | Completed

• 1 other identifier: 2020-122
• Study Type: observational
• Target: 44
• Locations: 1 country
• Sites: 1

Brief Summary

Sensory impairment is an important problem for patients with Multiple Sclerosis (MS). Although there is no complete loss of sensation in patients, 80% of patients have a significant sensory impairment. The sensory system plays an important role in providing the feedback required to perform motor tasks. Cutaneous sensation, especially in the sole of the foot, is very important in maintaining balance and gait. There are studies showing decreased foot sole sensation in MS patients. Another sensation that is important during motor tasks is the proprioceptive sensation. The aim of this study is to examine the relationship between the sensation of foot sole and joint position, clinical features, attention, fatigue, body awareness and physical activity level in patients with MS.

Conditions

Multiple Sclerosis

Keywords

Multiple Sclerosis; sensation; fatigue; physical activity

Outcome Measures

Primary Outcomes (4)

• Light touch-pressure sensation

  Light touch-pressure sensation will be assessed using a full Semmes-Weinstein Monofilament (SWM) test kit (North Coast Medical, San Jose, CA, USA).

  10 minutes

• Vibration sensation

  Duration of vibration sensation will be measured using 128-Hz frequency tuning fork (Elcon1 Medical Instruments, Tuttlingen, Germany).

  10 minutes]

• position sensation of knee joint

  Open kinetic chain position of both knees will be evaluated using a Dualer IQ Digital Inclinometer (J-Tech Medical, Midvale, UT, USA).

  5 minutes

• Knee proprioception

  Knee proprioception will be evaluated with the active joint reposition test using the isokinetic system (Cybex Norm, Humac, CA, USA).

  10 minutes

Secondary Outcomes (4)

• Fatigue Severity

  5 minutes

• attention

  5 minutes

• Physical Activity

  10 minutes

• Body Awareness

  5 minutes

Study Arms (2)

Patients with Multiple Sclerosis

MS patients (EDSS: 0-5,5)

Other: Assessment

Healthy group

Healthy individuals without chronic disease

Other: Assessment

Interventions

Assessment OTHER

Assessments of foot sole sensation, joint position sensation, attention, fatigue, body awareness, and physical activity level

Healthy group; Patients with Multiple Sclerosis

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

ambulatory sample

You may qualify if:

• years of age
• Having a diagnosis of "Multiple Sclerosis"
• Relapse free in the last 3 mounts
• Ambulatory status (Expanded Disability Status Scale score ≤ 6 )
• No diagnosis of depression

You may not qualify if:

• Any cardiovascular, orthopedic, visual, and hearing problems that may affect the results of the research

Sponsors & Collaborators

• Gazi University: lead

Study Sites (1)

Gazi University

Ankara, Turkey (Türkiye)

Location

Related Publications (5)

• Sanders EA, Arts RJ. Paraesthesiae in multiple sclerosis. J Neurol Sci. 1986 Jul;74(2-3):297-305. doi: 10.1016/0022-510x(86)90115-2.

  PMID: 3734839 BACKGROUND

• Merchut MP, Gruener G. Quantitative sensory threshold testing in patients with multiple sclerosis. Electromyogr Clin Neurophysiol. 1993 Mar;33(2):119-24.

  PMID: 8449168 BACKGROUND

• Kars HJ, Hijmans JM, Geertzen JH, Zijlstra W. The effect of reduced somatosensation on standing balance: a systematic review. J Diabetes Sci Technol. 2009 Jul 1;3(4):931-43. doi: 10.1177/193229680900300441.

  PMID: 20144343 BACKGROUND

• Eils E, Behrens S, Mers O, Thorwesten L, Volker K, Rosenbaum D. Reduced plantar sensation causes a cautious walking pattern. Gait Posture. 2004 Aug;20(1):54-60. doi: 10.1016/S0966-6362(03)00095-X.

  PMID: 15196521 BACKGROUND

• Eldemir K, Ozkul C, Yildirim MS, Eldemir S, Saygili F, Irkec C, Guclu-Gunduz A. Relationship between lower extremity sensation, physical activity, cognition, body awareness, and fatigue in people with multiple sclerosis: a cross-sectional study. Acta Neurol Belg. 2025 Jun;125(3):801-810. doi: 10.1007/s13760-025-02768-1. Epub 2025 Mar 26.

  PMID: 40133734 DERIVED

MeSH Terms

Conditions

Multiple Sclerosis; Fatigue; Motor Activity

Interventions

Restraint, Physical

Condition Hierarchy (Ancestors)

Demyelinating Autoimmune Diseases, CNS; Autoimmune Diseases of the Nervous System; Nervous System Diseases; Demyelinating Diseases; Autoimmune Diseases; Immune System Diseases; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Behavior

Intervention Hierarchy (Ancestors)

Behavior Control; Therapeutics; Immobilization; Investigative Techniques

Study Officials

• Cagla Ozkul

  Gazi University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: CROSS SECTIONAL
• Target Duration: 1 Day
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Research Assistant

Study Record Dates

• First Submitted: September 7, 2020
• First Posted: September 14, 2020
• Study Start: October 5, 2020
• Primary Completion: May 13, 2022
• Study Completion: May 13, 2022
• Last Updated: August 5, 2022

Record last verified: 2022-08

Locations

TU (1)