The Effects of Cricket- and Beef-derived Protein on Plasma Amino Acid Concentrations and Appetite Responses

NCT04719429 | Completed

• 1 other identifier: A08-M28-18B
• Study Type: interventional
• Target: 20
• Locations: 1 country
• Sites: 1

Brief Summary

Dietary protein plays an important role in appetite regulation. Source of ingested dietary protein may have different effects on appetite, satiety, and/or food intake in humans. Insects are a rich source of protein consumed by many people around the world; however, the capacity of insect-derived protein to regulate appetite and food intake is unclear. The purpose of this study was to compare postprandial plasma glucose, insulin, amino acid, and appetite regulatory hormone concentrations, subjective appetite sensations, and food intake following the ingestion of 25 g of cricket- and beef-derived protein in healthy young males.

Conditions

Aminoacidemia; Appetitive Behavior

Keywords

dietary protein; insect protein; young men; beef collagen; amino acids; appetite

Outcome Measures

Primary Outcomes (2)

• Plasma leucine concentration

  umol/L

  0-5 hours in the post-prandial period

• Subjective appetite sensations (hunger, fullness, desire to eat, prospective food consumption)

  mm (visual analogue scale)

  0-5 hours in the post-prandial period

Secondary Outcomes (9)

• Plasma branched-chain amino acid concentration

  0-5 hours in the post-prandial period

• Plasma essential amino acid concentration

  0-5 hours in the post-prandial period

• Plasma non-essential amino acid concentration

  0-5 hours in the post-prandial period

• Plasma total amino acid concentration

  0-5 hours in the post-prandial period

• Plasma glucose

  0-5 hours in the post-prandial period

Study Arms (2)

Cricket-derived protein beverage

EXPERIMENTAL

Ingestion of a cricket-derived protein beverage

Dietary Supplement: Cricket-derived Protein

Beef-derived protein beverage

EXPERIMENTAL

Ingestion of a beef-derived protein beverage

Dietary Supplement: Beef-derived Protein

Interventions

Cricket-derived Protein DIETARY_SUPPLEMENT

Beverage containing 25 g cricket-derived protein

Cricket-derived protein beverage

Beef-derived Protein DIETARY_SUPPLEMENT

Beverage containing 25 g beef-derived protein

Beef-derived protein beverage

Eligibility Criteria

• Age: 18 Years - 35 Years
• Sex: male
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Male
• Aged between 18-35 years inclusive
• Healthy, moderately active
• BMI \< 30 kg/m2 and \> 18.5 kg/m2
• Having given informed consent

You may not qualify if:

• Presence of any identified metabolic or intestinal disorders
• Use of tobacco products
• Adherence to a strict vegetarian or vegan diet
• Use of medications known to affect protein metabolism
• Allergy to shellfish or crustaceans
• Allergy to beef protein
• Engagement in physical exercise training more than 6 days per week

Sponsors & Collaborators

• McGill University: lead

Study Sites (1)

Exercise Metabolism and Nutrition Research Laboratory

Montreal, Quebec, H2W 1S4, Canada

Location

MeSH Terms

Conditions

Appetitive Behavior

Condition Hierarchy (Ancestors)

Behavior, Animal; Behavior

Study Officials

• Tyler A Churchward-Venne, Ph.D.

  McGill University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: QUADRUPLE
• Who Masked: PARTICIPANT, CARE PROVIDER, INVESTIGATOR, OUTCOMES ASSESSOR
• Purpose: BASIC SCIENCE
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Tyler A. Churchward-Venne, Ph.D., Assistant Professor, McGill University

Study Record Dates

• First Submitted: January 15, 2021
• First Posted: January 22, 2021
• Study Start: January 28, 2019
• Primary Completion: April 9, 2019
• Study Completion: April 9, 2019
• Last Updated: January 22, 2021

Record last verified: 2021-01

Data Sharing

• IPD Sharing: Will not share

Locations

CA (1)