Influence of Caffeinated and Non-caffeinated Pre-workout Supplements on Resistance Exercise Performance

NCT04712578 | Completed

• 2 other identifiers: IRB2020-81320-1299
• Study Type: interventional
• Target: 24
• Locations: 1 country
• Sites: 1

Brief Summary

This study is a randomized, double-blind, placebo-controlled crossover trial examining the effects of caffeinated and non-caffeinated pre-workout supplements on resistance exercise performance. Resistance-trained adults will be randomly assigned to complete three study conditions (caffeinated pre-workout, non-caffeinated pre-workout, and placebo) in one of the six possible condition orders. During each condition, participants will report to the laboratory for ingestion of the assigned beverage and subsequent muscular performance testing. Major performance outcomes will be force production variables from a mechanized squat device and maximal strength and muscular endurance on the bench press and leg press exercises.

Conditions

Resistance Training; Caffeine; Dietary Supplements

Keywords

caffeine; resistance training; resistance exercise; pre-workout supplement; dietary supplements

Outcome Measures

Primary Outcomes (8)

• Isometric Peak Force Production

  Peak isometric force produced on a mechanical squat device at an 120-degree knee angle.

  Approximately 35 minutes after beverage ingestion in each condition.

• Isometric Rate of Force Development

  Rate of force development produced on a mechanical squat device at an 120-degree knee angle.

  Approximately 35 minutes after beverage ingestion in each condition.

• Isokinetic Peak Concentric Force Production

  Peak concentric force produced during isokinetic testing on a mechanical squat device.

  Approximately 40 minutes after beverage ingestion in each condition.

• Isokinetic Peak Eccentric Force Production

  Peak eccentric force produced during isokinetic testing on a mechanical squat device.

  Approximately 40 minutes after beverage ingestion in each condition.

• Maximal Strength on Bench Press Exercise

  One-repetition maximum for the barbell bench press exercise.

  Approximately 65 minutes after beverage ingestion in each condition.

• Muscular Endurance on Bench Press Exercise

  Repetitions to failure on the bench press exercise, using a load corresponding to 0.4 times body mass for females and 0.75 times body mass for males.

  Approximately 70 minutes after beverage ingestion in each condition.

• Maximal Strength on Leg Press Exercise

  One-repetition maximum for the plate-loaded leg press exercise.

  Approximately 95 minutes after beverage ingestion in each condition.

• Muscular Endurance on Leg Press Exercise

  Repetitions to failure on the leg press exercise, using a load corresponding to 1.5 times body mass for females and 2.5 times body mass for males.

  Approximately 100 minutes after beverage ingestion in each condition.

Secondary Outcomes (3)

• Subjective Ratings of Energy

  Five total assessments in each condition. Immediately prior to: beverage ingestion, isometric exercise testing, bench press testing, and leg press testing. Also, immediately after leg press testing.

• Subjective Ratings of Focus

  Five total assessments in each condition. Immediately prior to: beverage ingestion, isometric exercise testing, bench press testing, and leg press testing. Also, immediately after leg press testing.

• Subjective Ratings of Fatigue

  Five total assessments in each condition. Immediately prior to: beverage ingestion, isometric exercise testing, bench press testing, and leg press testing. Also, immediately after leg press testing.

Other Outcomes (1)

• Participant Identification of Beverage

  At the very end of each condition (i.e., approximately 105 minutes after beverage ingestion in each condition; exact time of assessment may vary based on duration of exercise performance testing for each participant).

Study Arms (3)

Caffeinated Pre-workout Supplement

EXPERIMENTAL

This arm will consist of ingestion of the commercially available, caffeinated Pulse pre-workout, manufactured by Legion Athletics, Inc.

Dietary Supplement: Caffeinated pre-workout supplement

Non-Caffeinated Pre-Workout Supplement

ACTIVE COMPARATOR

This arm will consist of ingestion of the commercially available, non-caffeinated Pulse pre-workout, manufactured by Legion Athletics, Inc.

Dietary Supplement: Non-caffeinated pre-workout supplement

Placebo

PLACEBO COMPARATOR

This arm will consist of a flavor-matched placebo beverage without the active components contained in the supplements administered in the other study arms.

Dietary Supplement: Placebo

Interventions

Caffeinated pre-workout supplement DIETARY_SUPPLEMENT

The intervention will consist of consuming a standardized meal followed by one serving of the commercially available Pulse caffeinated pre-workout supplement (Legion Athletics, Inc.).

Also known as: Legion Athletics Pulse Pre-workout Supplement

Caffeinated Pre-workout Supplement

Non-caffeinated pre-workout supplement DIETARY_SUPPLEMENT

The intervention will consist of consuming a standardized meal followed by one serving of the commercially available Pulse non-caffeinated pre-workout supplement (Legion Athletics, Inc.).

Also known as: Legion Athletics Pulse Pre-workout Supplement

Non-Caffeinated Pre-Workout Supplement

Placebo DIETARY_SUPPLEMENT

The intervention will consist of consuming a standardized meal followed by a placebo beverage.

Placebo

Eligibility Criteria

• Age: 18 Years - 40 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Between the ages of 18 and 40;
• Body mass between 50 - 100 kg (110-220 lb)
• Generally healthy (defined as an absence of any disease or medical condition which could potentially be negatively affected by consumption of the commercially available dietary supplements or performance of exercise, including but not limited to musculoskeletal or cardiovascular diseases).
• Resistance-trained, defined as completing 2+ resistance training sessions per week for at least three months prior to screening.
• Participants must have reported regular training of the lower body through a multi-joint exercise such as the squat or leg press at least once weekly during the three-month period prior to screening.
• Participants must have reported regular training of the bench press or chest press variation at least once weekly during the three-month period prior to screening.
• Female participants will be required to bench press ≥ 0.5 x body mass and leg press ≥ 1.75 x body mass during initial 1RM assessments to be eligible for this study.
• Male participants will be required to bench press ≥ 1.0 x body mass and leg press ≥ 3.0 x body mass to be eligible.
• Regular caffeine consumption (due to the presence of caffeine in the commercially available dietary supplement). This will be defined as an average self-reported daily intake of 250+ mg of caffeine, which is equivalent to approximately 2.5 cups of coffee.

You may not qualify if:

• Pregnant or breastfeeding (for female participants)
• Taking prescription medication which could reasonably make participation unsafe for the participant or influence study outcomes
• An inability to complete resistance exercise due to injury or medical condition
• Self-reported caffeine sensitivity, as indicated by unwanted side effects when caffeine is consumed.
• Allergy to any of the ingredients in the test beverages or standardized breakfast.
• Current use of anabolic steroids
• Presence of a pacemaker or other implanted electrical device.
• Unwillingness to wear the provided surgical mask during all testing procedures.

Sponsors & Collaborators

• Texas Tech University: lead
• Legion Athletics, Inc: collaborator

Study Sites (1)

Department of Kinesiology & Sport Management

Lubbock, Texas, 79409, United States

Location

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: TRIPLE
• Who Masked: PARTICIPANT, INVESTIGATOR, OUTCOMES ASSESSOR
• Masking Details: All investigators will be blinded to the caffeinated vs. non-caffeinated supplement (i.e., these were provided by the manufacturer in a blinded manner). Select study investigators who will not be involved in assessing outcomes will formulate the placebo supplement and be responsible for dispensing all supplements to participants. Supplements will be provided to participants in opaque containers to maintain blinding. All investigators involved in assessing outcomes will also remain blinded and will not be involved in handling or dispensing the supplements.
• Purpose: OTHER
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Model Details: This study is a randomized, double-blind, placebo-controlled crossover trial.

Study Record Dates

• First Submitted: January 11, 2021
• First Posted: January 15, 2021
• Study Start: February 23, 2021
• Primary Completion: May 11, 2021
• Study Completion: May 11, 2021
• Last Updated: June 3, 2021

Record last verified: 2021-06

Locations

US (1)