Body Composition Changes During Overfeeding Plus Resistance Training

NCT04069351 | Completed

• 1 other identifier: IRB2019-356
• Study Type: interventional
• Target: 32
• Locations: 1 country
• Sites: 1

Brief Summary

This study will examine the relationship between the rate and composition of mass gain during overfeeding plus resistance training, investigate the validity of multiple assessment methods for quantifying body composition changes during this period, and evaluate the effects of subject presentation on the interpretation of body composition changes.

Conditions

Weight Gain; Resistance Training; Overeating

Outcome Measures

Primary Outcomes (7)

• Proportion of Body Mass Gained as Fat-Free Mass

  Calculated as change in fat-free mass (in kilograms) divided by change in body mass (in kilograms).

  6 weeks

• Rate of Body Mass Gain

  Rate of body mass gained calculated in kilograms gained per week.

  6 weeks

• Fat-free mass

  Fat-free mass in kilograms, assessed via multiple methods.

  6 weeks

• Fat mass

  Fat mass in kilograms, assessed via multiple methods.

  6 weeks

• Skeletal muscle size

  Muscle thickness in centimeters.

  6 weeks

• Resting metabolism

  Resting metabolism in kcal/day.

  6 weeks

• Body mass

  Body mass in kilograms

  6 weeks

Secondary Outcomes (5)

• Muscular Strength (1-repetition maximum test)

  6 weeks

• Muscular Endurance (repetitions until failure)

  6 weeks

• Skeletal Muscle Quality via Ultrasonography

  6 weeks

• Estimated Skeletal Muscle Glycogen

  6 weeks

• Estimated Skeletal Muscle Intramuscular Fat

  6 weeks

Study Arms (1)

Overfeeding Plus Resistance Training Arm

EXPERIMENTAL

6-week overfeeding plus resistance training arm

Dietary Supplement: High-calorie mass gainer supplement; Other: Resistance Training

Interventions

High-calorie mass gainer supplement DIETARY_SUPPLEMENT

A high-calorie mass gainer supplement will be provided to all participants to promote weight gain.

Overfeeding Plus Resistance Training Arm

Resistance Training OTHER

All participants will complete a 6-week supervised resistance training program.

Overfeeding Plus Resistance Training Arm

Eligibility Criteria

• Age: 18 Years - 40 Years
• Sex: male
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Between the ages of 18 and 40
• Male
• Generally healthy (defined as an absence of any disease or medical condition which could potentially be impacted by study participation, including but not limited to cardiac, musculoskeletal, pulmonary, renal, immunological, or metabolic diseases)
• Weight-stable (defined as no change in body mass \>5 pounds \[2.3 kg\] in the past 3 months)
• Willingness to adhere to study protocol, particularly the completion of the supervised resistance training program and consumption of dietary supplements
• Desire and/or willingness to attempt to gain body mass as part of study intervention
• Resistance trained (defined as performance of resistance training on 2 to 5 days for at least 6 months prior to study initiation), as well as meeting the objective criteria below
• Maximal strength \> 1.0 x body mass on the barbell bench press exercise, executed with proper form
• Maximal strength \> 2.0 x body mass on plate-loaded hip sled, executed with proper form

You may not qualify if:

• Height greater than 75.5 inches (due to height limitation of DXA scanner)
• Weight greater than 350 pounds (due to weight limitation of DXA scanner)
• Beard longer than ½ inch (and unwillingness to shave) due to the impact of facial hair on Bod Pod body volume estimates
• History of anabolic-androgenic steroid use, based on self-report

Sponsors & Collaborators

• Texas Tech University: lead
• Dymatize Enterprises, LLC: collaborator
• MuscleSound: collaborator

Study Sites (1)

Texas Tech University

Lubbock, Texas, 79409, United States

Location

Related Publications (1)

• Rodriguez C, Harty PS, Stratton MT, Siedler MR, Smith RW, Johnson BA, Dellinger JR, Williams AD, White SJ, Benavides ML, Tinsley GM. Comparison of Indirect Calorimetry and Common Prediction Equations for Evaluating Changes in Resting Metabolic Rate Induced by Resistance Training and a Hypercaloric Diet. J Strength Cond Res. 2022 Nov 1;36(11):3093-3104. doi: 10.1519/JSC.0000000000004077. Epub 2021 Jun 22.

  PMID: 34172636 DERIVED

MeSH Terms

Conditions

Weight Gain; Hyperphagia

Interventions

Resistance Training

Condition Hierarchy (Ancestors)

Body Weight Changes; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Signs and Symptoms, Digestive

Intervention Hierarchy (Ancestors)

Exercise Therapy; Rehabilitation; Aftercare; Continuity of Patient Care; Patient Care; Therapeutics; Physical Therapy Modalities; Physical Conditioning, Human; Exercise; Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: OTHER
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: August 14, 2019
• First Posted: August 28, 2019
• Study Start: September 18, 2019
• Primary Completion: November 26, 2019
• Study Completion: November 26, 2019
• Last Updated: May 7, 2020

Record last verified: 2020-05

Locations

US (1)