Blood and Muscle Response to Cheddar Cheese in Healthy Adults

NCT04660877 | Completed DMC

• 1 other identifier: 110963
• Study Type: interventional
• Target: 42
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this project is to use a cross over design in young healthy male and female adults:

1. 1.To determine the amino acid blood response to the acute ingestion of cheddar cheese in comparison to that of milk.
2. 2.To determine the muscle mTORC1 response to the acute ingestion of cheddar cheese in comparison to that of milk.

Conditions

Healthy

Outcome Measures

Primary Outcomes (1)

• Response to cheese or milk ingestion

  blood amino acids area under the curve in response to acute stimulation of cheese or milk consumption

  Area under the curve 0-300min after ingestion

Secondary Outcomes (1)

• Response to cheese or milk ingestion

  Change between 60min after ingestion and fasted response

Study Arms (2)

Cheddar chese

EXPERIMENTAL

Once enrolled, participants will either ingest 20 grams of protein from 1) cheese or 2) milk for the first Metabolic Study and then the other product when they return after the washout period (\~1 month) for Metabolic Study #2.

Dietary Supplement: Cheddar Cheese

Milk

ACTIVE COMPARATOR

Once enrolled, participants will ingest 20 grams of protein from 1) cheese or 2) milk for the first Metabolic Study and then the other product when they return after the washout period (\~1 month) for Metabolic Study #2.

Dietary Supplement: Milk

Interventions

Cheddar Cheese DIETARY_SUPPLEMENT

20g of protein from cheddar cheese

Cheddar chese

Milk DIETARY_SUPPLEMENT

20g of protein from milk

Milk

Eligibility Criteria

• Age: 18 Years - 35 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Age between 18-35y

You may not qualify if:

• History of cardiovascular disease
• History of endocrine or metabolic disease (e.g., hypo/hyperthyroidism, diabetes)
• History of kidney disease or failure
• History of liver disease
• History of respiratory disease (acute upper respiratory infection, chronic lung disease)
• History of stroke with motor disability
• Use of anticoagulant therapy (e.g., Coumadin, heparin) including aspirin and fish oils within 7d of the first biopsy experiment
• Elevated systolic blood pressure \>150 or a diastolic blood pressure \> 100
• Smoking
• Recent anabolic or corticosteroids use (within 12 weeks)
• Pregnancy as determined by a pregnancy test
• self report of lactose intolerance

Sponsors & Collaborators

• University of Utah: lead

Study Sites (1)

The University of Utah

Salt Lake City, Utah, 84112, United States

Location

MeSH Terms

Interventions

Milk

Intervention Hierarchy (Ancestors)

Beverages; Diet, Food, and Nutrition; Physiological Phenomena; Dairy Products; Food; Food and Beverages

Study Officials

• Micah Drummond

  University of Utah

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor

Model Details: Participants take part in an experiment in which they consume cheese then at another time consume milk

Study Record Dates

• First Submitted: December 1, 2020
• First Posted: December 9, 2020
• Study Start: June 28, 2018
• Primary Completion: August 20, 2019
• Study Completion: August 20, 2019
• Last Updated: June 22, 2022

Record last verified: 2022-06

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)