Imaging During Subliminal Perception
Functional Imaging During Subliminal Perception
1 other identifier
observational
70
1 country
1
Brief Summary
Subliminal perception of visual stimuli can be studied with functional brain imaging, e.g. with functional magnetic resonance imaging (fMRI). However, it is unclear how subliminal perception affects connectivity in the brain. Further, it is not known if real-time (rt) fMRI neurofeedback of brain areas involved in subliminal perception can lead to supra-threshold perception. For attention tasks, the investigators hypothesize that functional connectivity strength is mediated by the insular cortex during both supra-threshold and subliminal perception. Additionally, the investigators hypothesize that rt-fMRI neurofeedback training should alter neuronal and behavioral responses.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for all trials
Started Mar 2020
Typical duration for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
March 15, 2020
CompletedFirst Submitted
Initial submission to the registry
November 16, 2020
CompletedFirst Posted
Study publicly available on registry
November 25, 2020
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 1, 2021
CompletedStudy Completion
Last participant's last visit for all outcomes
December 1, 2022
CompletedJune 13, 2023
June 1, 2023
1.7 years
November 16, 2020
June 12, 2023
Conditions
Keywords
Outcome Measures
Primary Outcomes (2)
fMRI during supra-threshold and subliminal perception
2020 - 2022
rt-fMRI activity
rt-fMRI activity: fMRI signal changes during repetitive real time fMRI based training
2020 - 2022
Secondary Outcomes (3)
Functional connectivity
2020 - 2022
EEG activity
2020 - 2022
fMRI task performance
2020 - 2022
Study Arms (3)
active group 1
This group will train the insular cortex by real-time fMRI
active group 2
This group will train the visual cortex by real-time fMRI
sham
This group will only train the insula by a particular strategy
Interventions
Brain regions can be trained, i.e. fMRI activity can be actively modulated online by humans, using rt-fMRI (Bruhl, Scherpiet et al. 2014, Bruhl 2015, Emmert, Kopel et al. 2016).
Eligibility Criteria
Healthy adults
You may qualify if:
- Healthy adults (\> 18 \< 80 years), which can read and sign the informed consent form
- Male and female
- Right-handed
You may not qualify if:
- metallic items in the body (i.e. eye splinter, MR incompatible implants)
- pacemaker
- claustrophobia
- pregnant participants
- participants suffering from a degenerative disorder of the Central Nervous System, such as Stroke, Multiple Sclerosis, Parkinson's Disease, Alzheimer's Disease and Huntington's Disease and with major psychiatric disorders such as schizophrenia, depression, or anxiety disorder
- Drug intake (psychopharmaca)
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- University of Zurichlead
- Swiss National Science Foundationcollaborator
Study Sites (1)
University of Zurich
Zurich, Switzerland
Related Links
Study Officials
- PRINCIPAL INVESTIGATOR
Lars Michels, PhD
University Hospital, Zürich
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
November 16, 2020
First Posted
November 25, 2020
Study Start
March 15, 2020
Primary Completion
December 1, 2021
Study Completion
December 1, 2022
Last Updated
June 13, 2023
Record last verified: 2023-06