Verticality Perception Assessed by the Haptic Vertical

NCT02980432 | Completed

• 1 other identifier: shv_okn_study
• Study Type: interventional
• Target: 19
• Locations: 1 country
• Sites: 1

Brief Summary

The investigators previously shown that a rotating optokinetic stimulus results in shifts of the subjective visual vertical in healthy human subjects. However, the origin of these shifts is still poorly understood. Both torsional displacement of the eyes and a shift in the internal estimate of direction of gravity have been proposed as potential explanations. Here the investigators use a vision-independent setup to differentiate between these two hypotheses, predicting no impact of a rotating stimulus on the subjective haptic vertical if torsion triggers the shift.

Conditions

Healthy

Keywords

vestibular; spatial orientation; vision; optokinetic

Outcome Measures

Primary Outcomes (2)

• Adjustment errors of aligning a rod along perceived direction of gravity while an optokinetic stimulus is presented.

  This outcome parameter focuses on the adjustment errors of the subjective haptic vertical while presenting a visual bias (i.e. an optokinetic rotatory stimulus).

  60 minutes

• Trial-to-trial variability of aligning a rod along perceived direction of gravity while an optokinetic stimulus is presented.

  This outcome parameter focuses on the trial-to-trial variability of rod alignments along perceived direction of gravity when presenting a visual bias cue (i.e. an optokinetic rotatory stimulus).

  60 minutes

Secondary Outcomes (2)

• Comparison of adjustment errors between the subjective haptic vertical and the subjective visual vertical

  60 minutes

• Comparison of adjustment errors of perceived vertical using the subjective haptic vertical with and without presenting an optokinetic stimulus

  60 minutes

Study Arms (1)

intervention arm

EXPERIMENTAL

all participants will be assigned to the same arm. Interventions applied include presenting a visual line or a rod with or without a moving (rotating) background while being in different whole-body roll positions. Participants will be asked to adjust the line or the rod along perceived direction of gravity.

Other: changes in whole-body roll position and visual/haptic stimuli presented

Interventions

changes in whole-body roll position and visual/haptic stimuli presented OTHER

In different whole-body roll positions subjects will be presented a luminous line or a rod in combination with a moving or stationary background. Participants will be asked to align the line or the rod along perceived direction of gravity.

intervention arm

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• ages 18-65 years
• informed consent

You may not qualify if:

• peripheral-vestibular deficit
• disturbed consciousness
• history of sensory deficits
• visual field deficits
• other neurological or systemic disorder which can cause dementia or cognitive dysfunction
• intake of antidepressants, sedatives, or neuroleptics
• pregnancy, unless excluded by a negative pregnancy test
• known neck pain or status post neck trauma

Sponsors & Collaborators

• University of Zurich: lead

Study Sites (1)

University Hospital Zurich, Dept. of Neurology

Zurich, Canton of Zurich, 8091, Switzerland

Location

MeSH Terms

Conditions

Orientation, Spatial

Condition Hierarchy (Ancestors)

Spatial Behavior; Behavior

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: November 16, 2016
• First Posted: December 2, 2016
• Study Start: October 1, 2016
• Primary Completion: June 1, 2018
• Study Completion: June 28, 2018
• Last Updated: July 2, 2018

Record last verified: 2018-06

Data Sharing

• IPD Sharing: Will not share

Locations

CH (1)