NCT04637178

Brief Summary

The overall objective of the study is to identify molecular determinants of the efficacy of resistance training for improving endruance performance in elite cyclists

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
25

participants targeted

Target at below P25 for not_applicable

Timeline
Completed

Started Nov 2020

Shorter than P25 for not_applicable

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

November 12, 2020

Completed
4 days until next milestone

Study Start

First participant enrolled

November 16, 2020

Completed
3 days until next milestone

First Posted

Study publicly available on registry

November 19, 2020

Completed
3 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

February 26, 2021

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

February 26, 2021

Completed
Last Updated

March 1, 2021

Status Verified

November 1, 2020

Enrollment Period

3 months

First QC Date

November 12, 2020

Last Update Submit

February 26, 2021

Conditions

Elite Cyclists

Keywords

CyclingEndurance performanceSkeletal muscle biologyIndividualizationMuscle fiber type proportionsRibosomal RNA

Outcome Measures

Primary Outcomes (2)

  • Performance during a 40-minute all-out cycling test

    Mean power output measured during a 40-minute all-out cycling test

    Changes from before the intervention to immediately after the intervention

  • Performance during a 15-minute all-out cycling test

    Mean power output measured during a 15-minute all-out cycling test

    Changes from before the intervention to immediately after the intervention

Secondary Outcomes (25)

  • Total RNA in muscle tissue (before intervention)

    Before the intervention

  • Total RNA in muscle tissue (changes after two weeks)

    Changes from before the intervention to immediately after the initial two weeks of resistance training

  • Muscle fiber proportions (before intervention)

    Before the intervention

  • Muscle fiber proportions (changes after two weeks)

    Changes from before the intervention to immediately after the initial two weeks of resistance training

  • Muscle fiber cross-sectional area (before intervention)

    Before the intervention

  • +20 more secondary outcomes

Other Outcomes (2)

  • Endurance training volume

    Throughout study completion (daily), an average of ten weeks

  • Resistance training volume

    Throughout study completion (daily), an average of ten weeks

Study Arms (2)

Resistance training added to endurance training

EXPERIMENTAL

Participants (elite cyclists) will conduct heavy-load resistance training twice a week in addition to their habitual endurance training for ten weeks

Behavioral: Resistance trainingBehavioral: Endurance training (habitual)

Endurance training

OTHER

Participants (elite cyclists) will conduct habitual endurance training-only for ten weeks

Behavioral: Endurance training (habitual)

Interventions

Resistance trainingBEHAVIORAL

Resistance training sessions twice a week for ten weeks

Also known as: Heavy-load strength training
Resistance training added to endurance training
Endurance training (habitual)BEHAVIORAL

Endurance training for ten weeks (habitual routines)

Endurance trainingResistance training added to endurance training

Eligibility Criteria

Age18 Years - 45 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64)

You may qualify if:

  • VO2max \> 65 ml/kg/min (male participants)
  • VO2max \> 50 ml/kg/min (female participants)
  • \>7 hours of endurance training per week for the 6 months leading up to the study

You may not qualify if:

  • \- having conducted regular resistance training for the last 6 months leading up to the study

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Inland Norway University of Applied Sciences

Lillehammer, Inland Norway, 2613, Norway

Location

MeSH Terms

Interventions

Resistance TrainingEndurance Training

Intervention Hierarchy (Ancestors)

Exercise TherapyRehabilitationAftercareContinuity of Patient CarePatient CareTherapeuticsPhysical Therapy ModalitiesPhysical Conditioning, HumanExerciseMotor ActivityMovementMusculoskeletal Physiological PhenomenaMusculoskeletal and Neural Physiological Phenomena

Study Officials

  • Anne S Lofthus

    Research Administrator

    STUDY CHAIR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
DOUBLE
Who Masked
PARTICIPANT, INVESTIGATOR
Masking Details
Participants/investigators will be blinded to muscle biological charateristics until after clean-up of main outcome variables. Participants/investigators will be aware of intervention arm affiliation.
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

November 12, 2020

First Posted

November 19, 2020

Study Start

November 16, 2020

Primary Completion

February 26, 2021

Study Completion

February 26, 2021

Last Updated

March 1, 2021

Record last verified: 2020-11

Locations

NO(1)