Phase 2 Trial of Adagrasib Monotherapy and in Combination With Pembrolizumab and a Phase 3 Trial of Adagrasib in Combination in Patients With a KRAS G12C Mutation KRYSTAL-7
A Phase 2 Trial of Adagrasib Monotherapy and in Combination With Pembrolizumab and a Phase 3 Trial of Adagrasib in Combination With Pembrolizumab Versus Pembrolizumab in Patients With Advanced Non-Small Cell Lung Cancer With KRAS G12C Mutation
2 other identifiers
interventional
806
45 countries
754
Brief Summary
The Phase 2 portion of this study evaluates the efficacy and safety of MRTX849 monotherapy and in combination with pembrolizumab in cohorts of patients with advanced NSCLC with KRAS G12C mutation and any PD-L1 TPS and who are candidates for first-line treatment. The Phase 3 portion of the study compares the efficacy of adagrasib in combination with pembrolizumab versus pembrolizumab in patients with unresectable, locally advanced or metastatic squamous or nonsquamous NSCLC with KRAS G12C mutation and PD-L1 TPS \>=50% and who are candidates for first line treatment.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for phase_2
Started Dec 2020
Longer than P75 for phase_2
754 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
October 28, 2020
CompletedFirst Posted
Study publicly available on registry
November 3, 2020
CompletedStudy Start
First participant enrolled
December 2, 2020
CompletedPrimary Completion
Last participant's last visit for primary outcome
October 31, 2028
ExpectedStudy Completion
Last participant's last visit for all outcomes
October 31, 2029
March 18, 2026
March 1, 2026
7.9 years
October 28, 2020
March 17, 2026
Conditions
Keywords
Outcome Measures
Primary Outcomes (2)
Phase 2: To evaluate the efficacy of Adagrasib monotherapy and in combination with pembrolizumab administered to patients having advanced/metastatic NSCLC.
Objective Response Rate (ORR) as defined by Response Evaluation Criteria in Solid Tumors version 1.1 (RECIST 1.1)
22 months
Phase 3: To compare efficacy of Adagrasib in combination with pembrolizumab versus pembrolizumab
Progression Free Survival per RECIST 1.1 by Blinded Independent Central Review (BICR) and Overall Survival
36 months
Secondary Outcomes (12)
Phase 2: To characterize the safety and tolerability of study treatments in selected populations
22 months
Phase 2: Duration of Response
22 months
Phase 2: Progression Free Survival
22 months
Phase 2: To evaluate secondary efficacy endpoints using the study treatment in selected populations
12 months
Phase 2: To evaluate secondary efficacy endpoints using the study treatment in selected populations
22 months
- +7 more secondary outcomes
Study Arms (5)
Phase 2 Cohort 1a: PD-L1 TPS <1%
EXPERIMENTALCohort 1a: Adagrasib twice daily (BID) in combination with pembrolizumab
Phase 2 Cohort 1b: PD-L1 TPS <1%
EXPERIMENTALCohort 1b: Adagrasib BID monotherapy
Phase 2 Cohort 2: PD-L1 TPS ≥1%
EXPERIMENTALCohort 2: Adagrasib BID in combination with pembrolizumab
Phase 3 Cohort 3 Investigational Arm
EXPERIMENTALAdagrasib BID in combination with pembrolizumab
Phase 3 Cohort 4 Comparator Arm
ACTIVE COMPARATORPembrolizumab
Interventions
Adagrasib 400 mg twice daily (BID) in combination with pembrolizumab (Cohort 1a)
Eligibility Criteria
You may qualify if:
- Phase 2: Histologically confirmed diagnosis of unresectable or metastatic NSCLC with KRAS G12C mutation and any PD-L1 TPS
- Phase 3: Histologically confirmed diagnosis of unresectable or metastatic squamous or nonsquamous NSCLC with KRAS G12C mutation and PD-L1 TPS \>=50%
- Phase 3: Presence of evaluable or measurable disease per RECIST
- No evidence of brain metastases
- Untreated brain metastases not needing immediate local therapy
- Previously treated brain metastases not needing immediate local therapy
You may not qualify if:
- Phase 2 and Phase 3: Prior systemic treatment for locally advanced or metastatic NSCLC including chemotherapy, immune checkpoint inhibitor therapy, or a therapy targeting KRAS G12C mutation (e.g., AMG 510).
- Phase 2: Active brain metastases
- Phase 3: Patients with known central nervous system (CNS) lesions must not have any of the following:
- Any untreated brain lesions \> 1.0 cm in size
- Any brainstem lesions
- Ongoing use of systemic corticosteroids for control of symptoms of brain lesions at a total daily dose of \> 10 mg of prednisone (or equivalent) prior to randomization.
- Have poorly controlled (\> 1/week) generalized or complex partial seizures, or manifest neurologic progression due to brain lesions notwithstanding CNS-directed therapy
- Phase 3: Radiation to the lung \> 30 Gy within 6 months prior to the first dose of study treatment
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (764)
Local Institution - 007-556-A
Goodyear, Arizona, 85395, United States
USOR - Arizona Oncology - Prescott Valley
Prescott Valley, Arizona, 86301, United States
Local Institution - 007-568-A
Safford, Arizona, 85546, United States
Local Institution - 007-568-B
Safford, Arizona, 85546, United States
Local Institution - 007-568-C
Safford, Arizona, 85546, United States
Local Institution - 007-568-D
Safford, Arizona, 85546, United States
Local Institution - 007-568-E
Safford, Arizona, 85546, United States
Arizona Clinical Research Center
Tucson, Arizona, 85715, United States
Highlands Oncology Group - Springdale
Springdale, Arkansas, 72762, United States
Providence - Saint Joseph Home Health - Anaheim
Anaheim, California, 92805, United States
The Oncology Institute of Hope and Innovation - Corporate Office
Cerritos, California, 90703, United States
Local Institution - 007-777
Fountain Valley, California, 92708, United States
Local Institution - 007-778
Laguna Hills, California, 92653, United States
Local Institution - 007-898-B
Long Beach, California, 90805, United States
MemorialCare - Long Beach Medical Center
Long Beach, California, 90806, United States
TRIO - Cancer & Blood Specialty Clinic - Los Alamitos
Los Alamitos, California, 90720, United States
Local Institution - 007-579
Los Angeles, California, 90048, United States
Local Institution - Unk045
Rancho Mirage, California, 92270, United States
San Francisco Veterans Affairs Medical Center
San Francisco, California, 94121, United States
UCSF Helen Diller Family Comprehensive Cancer Center
San Francisco, California, 94158, United States
Local Institution - 007-898-C
Santa Ana, California, 92705, United States
Providence Medical Group - Santa Rosa
Santa Rosa, California, 95403, United States
Stockton Hematology Oncology Medical Group (SHOMG) - Stockton (Suite B)
Stockton, California, 95219, United States
Local Institution - 007-898-A
Whittier, California, 90602, United States
Local Institution - 007-872-H
Aurora, Colorado, 80012, United States
Local Institution - 007-872-D
Boulder, Colorado, 80303, United States
Local Institution - 007-872-L
Centennial, Colorado, 80112, United States
Local Institution - 007-872-C
Colorado Springs, Colorado, 80907, United States
Local Institution - 007-872-K
Colorado Springs, Colorado, 80920, United States
Local Institution - 007-872-E
Denver, Colorado, 80218, United States
Local Institution - 007-872-I
Denver, Colorado, 80220, United States
Local Institution - 007-872-A
Lakewood, Colorado, 80228, United States
Local Institution - 007-872-J
Littleton, Colorado, 80218, United States
USOR - Rocky Mountain Cancer Centers - Lone Tree
Lone Tree, Colorado, 80124, United States
Local Institution - 007-872-G
Longmont, Colorado, 80504, United States
Local Institution - 007-872-B
Pueblo, Colorado, 81003, United States
Local Institution - 007-872-F
Thornton, Colorado, 80260, United States
Eastern Connecticut Hematology and Oncology Associates
Norwich, Connecticut, 06360, United States
Local Institution - 007-5476
Washington D.C., District of Columbia, 20010, United States
GenesisCare USA
Aventura, Florida, 33180, United States
Bay Pines Veterans Affairs Healthcare System
Bay Pines, Florida, 33744, United States
Local Institution - 007-922-A
Bonita Springs, Florida, 34135, United States
Local Institution - 007-922-D
Bradenton, Florida, 34211, United States
Local Institution - 007-922-E
Cape Coral, Florida, 33909, United States
Local Institution - 007-896-A
Celebration, Florida, 34747, United States
Local Institution - 007-926-B
Daytona Beach, Florida, 32117, United States
Local Institution - 007-562-B
Fleming Island, Florida, 32003, United States
SCRI - Florida Cancer Specialists - South Region Research Office
Fort Myers, Florida, 33901, United States
Local Institution - 007-922-B
Fort Myers, Florida, 33905, United States
Local Institution - 007-922-C
Fort Myers, Florida, 33908, United States
21st Century Oncology of Jacksonville - North Lee Street
Jacksonville, Florida, 32204, United States
Local Institution - 007-562-D
Jacksonville, Florida, 32204, United States
Local Institution - 007-562-E
Jacksonville, Florida, 32207, United States
Local Institution - 007-562-G
Jacksonville, Florida, 32218, United States
Local Institution - 007-829
Jacksonville, Florida, 32224, United States
Cancer Specialists of North Florida - Southpoint
Jacksonville, Florida, 32256, United States
Local Institution - 007-562-C
Jacksonville, Florida, 32258, United States
Local Institution - 007-562-F
Jacksonville Beach, Florida, 32250, United States
Miami Veterans Affairs Healthcare System
Miami, Florida, 33125-1624, United States
Local Institution - 007-922-F
Naples, Florida, 34102, United States
Local Institution - 007-922-G
Naples, Florida, 34102, United States
AdventHealth Orlando
Orlando, Florida, 32803, United States
USOR - Woodlands Medical Specialists
Pensacola, Florida, 32503, United States
Local Institution - 007-922-H
Port Charlotte, Florida, 33980, United States
Local Institution - 007-562-A
Saint Augustine, Florida, 32086, United States
Local Institution - 007-922-I
Sarasota, Florida, 34232, United States
Local Institution - 007-922-J
Sarasota, Florida, 34236, United States
Local Institution - 007-926-D
Stuart, Florida, 34994, United States
Local Institution - 007-924-A
Tallahassee, Florida, 32308, United States
SCRI - Florida Cancer Specialists - Tallahassee Cancer Center
Tallahassee, Florida, 32308, United States
James A. Haley Veterans Hospital
Tampa, Florida, 33612, United States
Local Institution - Unk065
Tampa, Florida, 33612, United States
Local Institution - 007-922-L
Venice, Florida, 34285, United States
Local Institution - 007-922-K
Venice, Florida, 34292, United States
Local Institution - 007-926-C
Vero Beach, Florida, 32960, United States
Local Institution - 007-926-A
Wellington, Florida, 33414, United States
SCRI - Florida Cancer Specialists - West Palm Beach
West Palm Beach, Florida, 33401, United States
Local Institution - Unk072
Weston, Florida, 33331, United States
University Cancer & Blood Center (UCBC) - Athens
Athens, Georgia, 30607, United States
Local Institution - Unk052
Atlanta, Georgia, 30318, United States
Local Institution - 007-786-C
Carrollton, Georgia, 30117, United States
Local Institution - 007-786-A
Cartersville, Georgia, 30121, United States
Local Institution - 007-786-D
Douglasville, Georgia, 30134, United States
Local Institution - 007-786-B
Hiram, Georgia, 30141, United States
Central Georgia Cancer Care - Macon
Macon, Georgia, 31201, United States
Northwest Georgia Oncology Centers Wellstar - Marietta
Marietta, Georgia, 30060, United States
Local Institution - 007-897
Honolulu, Hawaii, 96813, United States
Local Institution - Unk005
Honolulu, Hawaii, 96813, United States
Local Institution - 007-883-A
Arlington Heights, Illinois, 60005, United States
Local Institution - 007-955
Chicago, Illinois, 60612, United States
University of Chicago
Chicago, Illinois, 60637, United States
Loyola University Medical Center
Maywood, Illinois, 60153, United States
USOR - Illinois Cancer Specialists - Niles
Niles, Illinois, 60714, United States
Advocate Medical Group Oncology
Park Ridge, Illinois, 60068, United States
Local Institution - Unk061
Peoria, Illinois, 61603-3200, United States
Goshen Center for Cancer Care
Goshen, Indiana, 46526, United States
Local Institution - 007-942-B
Chanute, Kansas, 66720, United States
Local Institution - 007-942-D
El Dorado, Kansas, 67042, United States
Local Institution - 007-942-E
Independence, Kansas, 67301, United States
Local Institution - 007-942-F
Kingman, Kansas, 67068, United States
Local Institution - 007-942-G
Liberal, Kansas, 67901, United States
Local Institution - 007-942-H
McPherson, Kansas, 67460, United States
MidAmerica Cancer Care - Research
Merriam, Kansas, 66204, United States
Local Institution - 007-942-I
Newton, Kansas, 67114, United States
Local Institution - 007-942-J
Parsons, Kansas, 67357, United States
Local Institution - 007-942-K
Pratt, Kansas, 67124, United States
Local Institution - 007-942-L
Salina, Kansas, 67401, United States
Local Institution - 007-942-M
Wellington, Kansas, 67152, United States
Local Institution - Unk032
Westwood, Kansas, 66205, United States
Local Institution - 007-942-A
Wichita, Kansas, 67208, United States
Cancer Center of Kansas - Wichita - Heritage Plaza
Wichita, Kansas, 67214, United States
Local Institution - 007-942-N
Winfield, Kansas, 67156, United States
Lexington Medical Cancer Center Hematology/Oncology
Lexington, Kentucky, 40503, United States
University of Louisville
Louisville, Kentucky, 40202, United States
Local Institution - 007-388-A
Louisville, Kentucky, 40245, United States
Local Institution - Unk011
Baton Rouge, Louisiana, 70809, United States
Local Institution - 007-994-A
Covington, Louisiana, 70433, United States
Pontchartrain Cancer Center - Covington Office
Covington, Louisiana, 70433, United States
The Sidney Kimmel Comprehensive Cancer Center
Baltimore, Maryland, 21231, United States
Dana-Farber Cancer Institute
Boston, Massachusetts, 02215, United States
Dana-Farber Cancer Institute at St. Elizabeths Medical Center
Brighton, Massachusetts, 02135, United States
Brigham and Womens/Mass General Health Care Center at Foxborough
Foxborough, Massachusetts, 02035, United States
Dana-Farber Cancer Institute - Merrimack Valley
Methuen, Massachusetts, 01844, United States
Dana-Farber Brigham and Womens Cancer Center at Milford Regional
Milford, Massachusetts, 01757, United States
Dana-Farber Brigham Cancer Center at South Shore Health
South Weymouth, Massachusetts, 02190, United States
USOR - Minnesota Oncology - Burnsville
Burnsville, Minnesota, 55337, United States
Local Institution - 007-589A
Edina, Minnesota, 55435, United States
Local Institution - Unk006
Minneapolis, Minnesota, 55404, United States
Local Institution - 007-822
Minneapolis, Minnesota, 55455, United States
Local Institution - 007-830
Rochester, Minnesota, 55905, United States
Jackson Oncology Associates - The Hederman Cancer Center
Jackson, Mississippi, 39202, United States
Local Institution - 007-590D
Grand Island, Nebraska, 68803, United States
Local Institution - 007-590A
Omaha, Nebraska, 68114-4108, United States
Local Institution - 007-590B
Omaha, Nebraska, 68124, United States
Nebraska Cancer Specialists - Midwest Cancer Center - Legacy
Omaha, Nebraska, 68130, United States
Local Institution - 007-590C
Papillion, Nebraska, 68046, United States
OptumCare Nevada
Las Vegas, Nevada, 89106, United States
Local Institution - 007-938A
Las Vegas, Nevada, 89148, United States
Local Institution - 007-938B
Las Vegas, Nevada, 89148, United States
Local Institution - 007-993
Belleville, New Jersey, 07109, United States
Astera Cancer Care - East Brunswick
East Brunswick, New Jersey, 08816, United States
John Theurer Cancer Center
Hackensack, New Jersey, 07601, United States
Local Institution - 007-975-A
Somerset, New Jersey, 08873-5002, United States
Local Institution - 007-975-B
Somerset, New Jersey, 08873-5002, United States
Local Institution - 007-975-C
Somerset, New Jersey, 08873-5002, United States
Local Institution - 007-975-D
Somerset, New Jersey, 08873-5002, United States
Holy Name Medical Center
Teaneck, New Jersey, 07666, United States
New York Oncology Hematology - Albany Medical Center
Albany, New York, 12208, United States
Local Institution - Unk077
Rhinebeck, New York, 12572, United States
Montefiore Medical Center
The Bronx, New York, 10467, United States
Duke University Medical Center
Durham, North Carolina, 27710, United States
Local Institution - 007-893-B
Cincinnati, Ohio, 45211, United States
USOR - Oncology Hematology Care - Blue Ash
Cincinnati, Ohio, 45242, United States
Local Institution - 007-893-C
Cincinnati, Ohio, 45245, United States
University Hospitals Cleveland Medical Center
Cleveland, Ohio, 44106, United States
Mark H. Zangmeister Cancer Center
Columbus, Ohio, 43219, United States
Local Institution - 007-893-A
Fairfield, Ohio, 45014, United States
Kettering Health Cancer Center - Main Campus
Kettering, Ohio, 45429, United States
Tricounty Hematology and Oncology - Massillon
Massillon, Ohio, 44646, United States
USOR - Willamette Valley Cancer Institute and Research Center - Eugene
Eugene, Oregon, 97401, United States
Local Institution - 007-885B
Portland, Oregon, 97213, United States
Local Institution - 007-885A
Portland, Oregon, 97227, United States
Oregon Oncology Specialists
Salem, Oregon, 97301, United States
Local Institution - 007-885C
Tigard, Oregon, 97223, United States
Local Institution - Unk041
Allentown, Pennsylvania, 18103-6218, United States
Veterans Affairs Pittsburgh Healthcare System - University Drive Campus
Pittsburgh, Pennsylvania, 15240, United States
Local Institution - 007-960
Providence, Rhode Island, 02903, United States
Local Institution - Unk038
Charleston, South Carolina, 29414, United States
Local Institution - 007-5475
Spartanburg, South Carolina, 29303, United States
Avera Cancer Institute
Sioux Falls, South Dakota, 57105, United States
Local Institution - 007-928-L
Dickson, Tennessee, 37055, United States
Local Institution - 007-928-J
Franklin, Tennessee, 37067, United States
Local Institution - 007-928-G
Gallatin, Tennessee, 37066, United States
West Cancer Center & Research Institute - East Campus
Germantown, Tennessee, 38138, United States
Local Institution - 007-928-A
Hendersonville, Tennessee, 37075, United States
Local Institution - 007-928-D
Hermitage, Tennessee, 37076, United States
Local Institution - 007-928-H
Lebanon, Tennessee, 37090, United States
Local Institution - 007-928-F
Murfreesboro, Tennessee, 37129, United States
Local Institution - 007-928-B
Nashville, Tennessee, 37203, United States
Tennessee Oncology - Nashville - Centennial Clinic - Medical Oncology
Nashville, Tennessee, 37203, United States
Local Institution - 007-928-K
Nashville, Tennessee, 37205, United States
Local Institution - 007-928-E
Nashville, Tennessee, 37207, United States
Local Institution - 007-928-C
Nashville, Tennessee, 37211, United States
Local Institution - 007-928-M
Shelbyville, Tennessee, 37160, United States
Local Institution - 007-928-I
Smyrna, Tennessee, 37167, United States
Local Institution - 007-554B
Abilene, Texas, 79606, United States
Local Institution - 007-554G
Amarillo, Texas, 79124, United States
Local Institution - 007-879-A
Arlington, Texas, 76012, United States
Local Institution - 007-879-B
Arlington, Texas, 76014, United States
Local Institution - 007-892-B
Austin, Texas, 78705, United States
Local Institution - 007-892-A
Austin, Texas, 78731, United States
USOR - Texas Oncology - Dallas Fort Worth (DFW) - South Austin
Austin, Texas, 78745, United States
Local Institution - 007-879-C
Bedford, Texas, 76022, United States
Local Institution - Unk059
Dallas, Texas, 75204, United States
Local Institution - 007-592
Dallas, Texas, 75216, United States
Texas Oncology - Dallas Fort Worth (DFW) - Baylor Charles A. Sammons Cancer Center
Dallas, Texas, 75246, United States
USOR - Texas Oncology Northeast Texas - Denison
Denison, Texas, 75020, United States
Local Institution - 007-554E
El Paso, Texas, 79902, United States
Local Institution - 007-554C
El Paso, Texas, 79915, United States
Local Institution - 007-554F
El Paso, Texas, 79938, United States
USOR - Texas Oncology - Fredericksburg
Fredericksburg, Texas, 78624, United States
Local Institution - 007-848
Houston, Texas, 77030, United States
Local Institution - 007-999
Irving, Texas, 75063, United States
Local Institution - 007-890-B
Longview, Texas, 75601, United States
Local Institution - 007-554A
Midland, Texas, 79701, United States
USOR - Texas Oncology - Dallas Fort Worth (DFW) - Odessa West Texas Cancer Center
Odessa, Texas, 79761, United States
USOR - Texas Oncology - The Woodlands
The Woodlands, Texas, 77380, United States
Local Institution - 007-890-A
Tyler, Texas, 75702, United States
Local Institution - 007-554D
Wichita Falls, Texas, 76310, United States
Local Institution - 007-912
Salt Lake City, Utah, 84112, United States
Local Institution - 007-814-A
Alexandria, Virginia, 22304, United States
Local Institution - 007-814-D
Arlington, Virginia, 22201, United States
USOR - Virginia Cancer Specialists - Fairfax Office
Fairfax, Virginia, 22031, United States
Local Institution - 007-814-B
Gainesville, Virginia, 20155, United States
Local Institution - 007-814-C
Leesburg, Virginia, 20176, United States
Virginia Cancer Institute - West End
Richmond, Virginia, 23229, United States
USOR - Northwest Cancer Specialists, P.C. dba Compass Oncology - Vancouver Cancer Center
Vancouver, Washington, 98684, United States
Local Institution - Unk064
Huntington, West Virginia, 25705, United States
Local Institution - Unk057
Madison, Wisconsin, 53715, United States
Local Institution - Unk068
Madison, Wisconsin, 53792, United States
Aresma - Clinica Adventista Belgrano
Belgrano, Buenos Aires, C1430EGF, Argentina
Fundacion Respirar
Ciudad Autonoma de Buenos Aires, Buenos Aires, 1426, Argentina
Local Institution - Unk043
Ciudad Autonoma de Buenos Aires, Buenos Aires, C1199ABB, Argentina
Instituto Argentino de Diagnostico y Tratamiento
Ciudad Autonoma de Buenos Aires, Buenos Aires, C1427ARO, Argentina
Local Institution - 007-436
Pergamino, Buenos Aires, B2700KMP, Argentina
Centro Oncologico Korben
San Pedro, Buenos Aires, B2930, Argentina
Instituto de Oncologia de Rosario
Rosario, Santa Fe Province, S2000KZE, Argentina
Sanatorio Parque
Rosario, Santa Fe Province, S2000, Argentina
Local Institution - Unk053
Buenos Aires, C1426ANZ, Argentina
Local Institution - 007-5002
Buenos Aires, C1431, Argentina
Instituto Oncologico de Cordoba (IONC)
Córdoba, X5000AAI, Argentina
Local Institution - Unk033
Porto Alegre, 91350-200, Argentina
Local Institution - Unk020
Río Cuarto, X5800, Argentina
Local Institution - 007-433
Viedma, R8500ACE, Argentina
Ballarat Regional Integrated Cancer Center
Ballarat, 3350, Australia
Flinders Medical Centre
Bedford Park, 5042, Australia
Local Institution - 007-004
Clayton, 3168, Australia
Canberra Hospital
Garran, 2605, Australia
Icon Cancer Centre
Hyde Park, 4812, Australia
Port Macquarie Base Hospital
Port Macquarie, 2444, Australia
Cancer Care Wollongong
Wollongong, 2500, Australia
Princess Alexandra Hospital
Woolloongabba, 4102, Australia
Klinikum Klagenfurt Am Worthersee
Klagenfurt, 9020, Austria
Universitatsklinikum Krems
Krems, 3500, Austria
Ordensklinikum Linz Elisabethinen
Linz, 4020, Austria
Medizinische Universitat Wien
Vienna, 1090, Austria
Wiener Gesundheitsverbund - Klinik Hietzing
Vienna, 1130, Austria
Wiener Gesundheitsverbund - Klinik Floridsdorf
Vienna, 1210, Austria
Universitair Ziekenhuis Antwerpen
Edegem, 2650, Belgium
Algemeen Ziekenhuis Maria Middelares
Ghent, 9000, Belgium
Jessa Ziekenhuis - Campus Virga Jesse
Hasselt, 3500, Belgium
Local Institution - 007-152
Roeselare, 8800, Belgium
Local Institution - 007-5050
Salvador, Estado de Bahia, 40170-110, Brazil
Local Institution - 007-458
Natal, Rio Grande do Norte, 59062-000, Brazil
Local Institution - Unk050
Lajeado, Rio Grande do Sul, 95900-000, Brazil
Local Institution - Unk015
Porto Alegre, Rio Grande do Sul, 90619-900, Brazil
Local Institution - 007-5051
Florianópolis, Santa Catarina, 88034-000, Brazil
Local Institution - Unk060
Barretos, 14783-213, Brazil
Local Institution - 007-457
Barretos, 14784-400, Brazil
Local Institution - Unk002
Ijuí, 98700-000, Brazil
Local Institution - 007-459
Porto Alegre, 91350-200, Brazil
Local Institution - Unk003
Rio de Janeiro, 20231-050, Brazil
Local Institution - Unk019
São José do Rio Preto, 15090-000, Brazil
Local Institution - Unk074
São Paulo, 01246-000, Brazil
Multiprofile Hospital For Active Treatment - Dr. Tota Venkova
Gabrovo, 5300, Bulgaria
Specialized Hospital for Active Oncology Treatment - Haskovo SLLC (SBALO - Haskovo - EOOD)
Haskovo, 6304, Bulgaria
Complex Oncology Center - Plovdiv - Base II
Plovdiv, 4004, Bulgaria
University Multiprofile Hospital for Active Treatment St. Ivan Rilski
Sofia, 1431, Bulgaria
Complex Oncology Center - Vratsa
Vratsa, 3001, Bulgaria
Cross Cancer Institute
Edmonton, Alberta, T6G 1Z2, Canada
British Columbia Cancer Agency - Vancouver
Vancouver, British Columbia, V5Z 4E6, Canada
Local Institution - 007-489
London, Ontario, N6A 5W9, Canada
Ottawa Hospital - General Campus
Ottawa, Ontario, K1H 8L6, Canada
Princess Margaret Cancer Centre
Toronto, Ontario, M5G 2M9, Canada
Local Institution - 007-490
Montreal, Quebec, H3A 0G4, Canada
Local Institution - Unk028
Santiago, 0, Chile
Local Institution - Unk073
Temuco, 4810469, Chile
Local Institution - 007-051
Bengbu, Anhui, 233000, China
The First Affiliated Hospital of Bengbu Medical College/Department of Respiratory and Critical Care Medicine
Bengbu, Anhui, 233000, China
Anhui Provincial Hospital
Hefei, Anhui, 230002, China
Local Institution - 007-026-Ph2
Hefei, Anhui, 230002, China
Local Institution - 007-026
Hefei, Anhui, 230002, China
Local Institution - 007-739-Ph2
Hefei, Anhui, 230002, China
Local Institution - 007-739
Hefei, Anhui, 230002, China
Local Institution - 007-747
Hefei, Anhui, 230002, China
Cancer Hospital Chinese Academy of Medical Sciences/Medical Oncology Department
Beijing, Beijing Municipality, 100021, China
Local Institution - 007-050
Beijing, Beijing Municipality, 100021, China
Local Institution - 007-707-Ph2
Beijing, Beijing Municipality, 100032, China
Local Institution - 007-707
Beijing, Beijing Municipality, 100032, China
Local Institution - 1025-Ph2
Beijing, Beijing Municipality, 100071, China
Local Institution - 1025
Beijing, Beijing Municipality, 100071, China
Beijing Cancer Hospital/Thoracic Oncology(2nd) Department
Beijing, Beijing Municipality, 100142, China
Beijing Cancer hospital
Beijing, Beijing Municipality, 100142, China
Local Institution - 007-027-Ph2
Beijing, Beijing Municipality, 100142, China
Local Institution - 007-038-Ph2
Beijing, Beijing Municipality, 100142, China
Local Institution - 007-038
Beijing, Beijing Municipality, 100142, China
Local Institution - 007-040-Ph2
Beijing, Beijing Municipality, 100142, China
Local Institution - 007-040
Beijing, Beijing Municipality, 100142, China
Local Institution - 007-718-Ph3
Chongqing, Chongqing Municipality, 400030, China
Local Institution - 1029-Ph2
Chongqing, Chongqing Municipality, 400037, China
Local Institution - 1029
Chongqing, Chongqing Municipality, 400037, China
Chongqing University Three Gorges Hospital/Respiratory Ward of Tumor Center
Chongqing, Chongqing Municipality, 404000, China
Local Institution - 007-053
Chongqing, Chongqing Municipality, 404000, China
Local Institution - 1046-Ph2
Fuzhou, Fujian, 350000, China
Local Institution - 1046
Fuzhou, Fujian, 350000, China
Fujian Cancer Hospital
Fuzhou, Fujian, 350014, China
Local Institution - 007-039-Ph2
Fuzhou, Fujian, 350014, China
Local Institution - 007-039
Fuzhou, Fujian, 350014, China
Local Institution - 007-714-Ph2
Xiamen, Fujian, 361003, China
Local Institution - 007-714
Xiamen, Fujian, 361003, China
Local Institution - 007-732-Ph2
Xiamen, Fujian, 361003, China
Local Institution - 007-732
Xiamen, Fujian, 361003, China
The First Affiliated Hospital of Xiamen University/Medical Oncology Department
Xiamen, Fujian, 361003, China
Local Institution - 1022-Ph2
Guangzhou, Guangdong, 510030, China
Local Institution - 1022
Guangzhou, Guangdong, 510030, China
Local Institution - 007-712-Ph2
Guangzhou, Guangdong, 510120, China
Local Institution - 007-712
Guangzhou, Guangdong, 510120, China
The First Affiliated Hospital of Guangzhou Medical University
Guangzhou, Guangdong, 510120, China
Local Institution - 007-705-Ph2
Guangzhou, Guangdong, 510515, China
Local Institution - 007-705
Guangzhou, Guangdong, 510515, China
Nanfang Hospital, Southern Medical University/Respiratory Medicine Department
Guangzhou, Guangdong, 510515, China
Local Institution - 007-052
Shenzhen, Guangdong, 518000, China
Shenzhen People's Hospital/Department of Respiratory and Critical Care Medicine
Shenzhen, Guangdong, 518000, China
Local Institution - 007-704-Ph2
Liuchow, Guangxi, 545006, China
Local Institution - 007-704
Liuchow, Guangxi, 545006, China
Guangxi Medical University Cancer Hospital/Department of Respiratory Oncology
Nanning, Guangxi, 530021, China
Local Institution - 007-384
Nanning, Guangxi, 530021, China
Local Institution - 007-744-Ph2
Nanning, Guangxi, 530021, China
Local Institution - 1038-Ph2
Nanning, Guangxi, 530021, China
Local Institution - 1038
Nanning, Guangxi, 530021, China
Local Institution - 007-742
Shijiazhuang, Hebei, 000000, China
The Fourth Hospital of Hebei Medical University
Shijiazhuang, Hebei, 000000, China
Cancer Hospital affiliated to Harbin Medical University/Ward 3 of Respiratory Medicine Department
Harbin, Heilongjiang, 150000, China
Local Institution - 007-028-Ph2
Harbin, Heilongjiang, 150000, China
Local Institution - 007-028
Harbin, Heilongjiang, 150000, China
Local Institution - 1012-Ph2
Xinxiang, Henan, 453100, China
Henan Cancer Hospital/Second Ward of Respiratory Medicine Department
Zhengzhou, Henan, 000000, China
Local Institution - 007-730-Ph3
Zhengzhou, Henan, 450000, China
Local Institution - 1010-Ph2
Zhengzhou, Henan, 450003, China
Local Institution - 1010
Zhengzhou, Henan, 450003, China
Local Institution - 007-021-Ph2
Zhengzhou, Henan, 450008, China
Local Institution - 007-715-Ph2
Zhengzhou, Henan, 450052, China
Local Institution - 007-715
Zhengzhou, Henan, 450052, China
Local Institution - 007-730-Ph2
Zhengzhou, Henan, 450052, China
Local Institution - 007-719-Ph2
Wuhan, Hubei, 430022, China
Union Hospital Affiliated with Tongji Medical College of Huazhong University of Science and Technology/Cancer Center Department
Wuhan, Hubei, 430022, China
Local Institution - 007-700-Ph2
Wuhan, Hubei, 430079, China
Local Institution - 007-700
Wuhan, Hubei, 430079, China
Local Institution - 007-701-Ph2
Changsha, Hunan, 410006, China
Hunan Cancer Hospital/Thoracic Medicine Department II
Changsha, Hunan, 410013, China
Local Institution - 1021-Ph2
Nanjing, Jiangsu, 210001, China
Local Institution - 1021
Nanjing, Jiangsu, 210001, China
Nanjing First Hospital/Department of Respiratory and Critical Care Medicine
Nanjing, Jiangsu, 210001, China
Nanjing First Hospital/Respiratory Department
Nanjing, Jiangsu, 210006, China
Local Institution - 1018-Ph2
Nanjing, Jiangsu, 210008, China
Local Institution - 1018
Nanjing, Jiangsu, 210008, China
Local Institution - 1020-Ph2
Nanjing, Jiangsu, 210029, China
Local Institution - 1020
Nanjing, Jiangsu, 210029, China
Local Institution - 1004-Ph2
Nantong, Jiangsu, 226361, China
Local Institution - 1004
Nantong, Jiangsu, 226361, China
Local Institution - 1017-Ph2
Xuzhou, Jiangsu, 221009, China
Local Institution - 1017
Xuzhou, Jiangsu, 221009, China
Local Institution - 007-713-Ph2
Nanchang, Jiangxi, 330006, China
Local Institution - 1040-Ph2
Nanchang, Jiangxi, 330006, China
Local Institution - 1040
Nanchang, Jiangxi, 330006, China
The First Affiliated Hospital of Nanchang University
Nanchang, Jiangxi, 330006, China
Local Institution - 1006-Ph2
Changchun, Jilin, 130012, China
Local Institution - 1006
Changchun, Jilin, 130012, China
Local Institution - 007-717-Ph2
Changchun, Jilin, 130021, China
The First Bethune Hospital Of Jilin University/Oncology Department
Changchun, Jilin, 130021, China
Local Institution - 007-741-Ph2
Shenyang, Liaoning, 110004, China
Local Institution - 007-741
Shenyang, Liaoning, 110004, China
Local Institution - 1008-Ph2
Shenyang, Liaoning, 110004, China
Local Institution - 1008
Shenyang, Liaoning, 110004, China
Local Institution - 007-749
Shenyang, Liaoning, 110022, China
Shengjing Hospital of China Medical University
Shenyang, Liaoning, 110022, China
Local Institution - 007-702-Ph2
Shenyang, Liaoning, 110042, China
Local Institution - 007-702
Shenyang, Liaoning, 110042, China
Local Institution - 007-746-Ph3
Yinchuan, Ningxia, 750001, China
Local Institution - 007-746
Yinchuan, Ningxia, 750001, China
Local Institution - 007-718-Ph2
Xi'an, Shaanxi, 710061, China
Local Institution - 007-721-Ph2
Xi'an, Shaanxi, 710061, China
Local Institution - 007-721
Xi'an, Shaanxi, 710061, China
The First Affiliated Hospital of Xi'an Jiaotong University/Medical Oncology Department
Xi'an, Shaanxi, 710061, China
Local Institution - 007-708-Ph2
Jinan, Shandong, 250117, China
Shandong Cancer Hospital
Jinan, Shandong, 250117, China
Local Institution - 007-737-Ph2
Linyi, Shandong, 276001, China
Linyi Cancer Hospital/Oncology Department
Linyi, Shandong, 276034, China
Local Institution - 007-703-Ph2
Linyi, Shandong, 276034, China
Local Institution - 007-703
Linyi, Shandong, 276034, China
Local Institution - 007-709-Ph2
Shanghai, Shanghai Municipality, 200030, China
Local Institution - 007-709
Shanghai, Shanghai Municipality, 200030, China
Shanghai Chest Hospital-Oncology department
Shanghai, Shanghai Municipality, 200030, China
Fudan University Shanghai Cancer Center/Thoracic Oncology Department
Shanghai, Shanghai Municipality, 200032, China
Local Institution - 007-024-Ph2
Shanghai, Shanghai Municipality, 200032, China
Local Institution - 007-024-Ph3
Shanghai, Shanghai Municipality, 200032, China
Local Institution - 007-024
Shanghai, Shanghai Municipality, 200032, China
Local Institution - 007-035-Ph2
Shanghai, Shanghai Municipality, 200032, China
Local Institution - 007-740-Ph2
Taiyuan, Shanxi, 030013, China
Local Institution - 007-740
Taiyuan, Shanxi, 030013, China
Local Institution - 007-748
Taiyuan, Shanxi, 030013, China
Shanxi Provincial Cancer Hospital/Respiratory Medicine
Taiyuan, Shanxi, 030013, China
Local Institution - 007-710-Ph2
Chengdu, Sichuan, 610041, China
Local Institution - 007-710
Chengdu, Sichuan, 610041, China
Local Institution - 007-720-Ph2
Chengdu, Sichuan, 610041, China
Sichuan Cancer hospital
Chengdu, Sichuan, 610041, China
West China Hospital of Sichuan University
Chengdu, Sichuan, 611135, China
Local Institution - 007-711-Ph2
Luzhou, Sichuan, 646000, China
Local Institution - 007-711
Luzhou, Sichuan, 646000, China
Xinjiang Medical University Cancer Hospital - Urumqi
Ürümqi, Xinjiang, 830000, China
Local Institution - 007-743
Ürümqi, Xinjiang, 830011, China
Local Institution - 1036-Ph2
Ürümqi, Xinjiang, 830011, China
Local Institution - 1036
Ürümqi, Xinjiang, 830011, China
Local Institution - 1032-Ph2
Kunming, Yunnan, 650100, China
Local Institution - 1032
Kunming, Yunnan, 650100, China
Local Institution - 007-385-Ph3
Kunming, Yunnan, 650106, China
Local Institution - 007-385
Kunming, Yunnan, 650106, China
Local Institution - 007-745-Ph2
Kunming, Yunnan, 650106, China
Local Institution - 007-745
Kunming, Yunnan, 650106, China
Local Institution - 007-716-Ph2
Hangzhou, Zhejiang, 310003, China
Local Institution - 007-716
Hangzhou, Zhejiang, 310003, China
The First Affiliated Hospital, Zhejiang University School of Medicine
Hangzhou, Zhejiang, 310006, China
Local Institution - 007-036-Ph2
Hangzhou, Zhejiang, 310016, China
Local Institution - 007-036
Hangzhou, Zhejiang, 310016, China
Local Institution - 007-037-Ph2
Hangzhou, Zhejiang, 310022, China
Zhejiang Cancer Hospital
Hangzhou, Zhejiang, 310022, China
Local Institution - 1050-Ph2
Taizhou, Zhejiang, 317099, China
Local Institution - 1050
Taizhou, Zhejiang, 317099, China
Taizhou Hospital Of Zhejiang Province
Taizhou, Zhejiang, 317099, China
Local Institution - 1043-Ph2
Qingdao, 266011, China
Local Institution - 1043
Qingdao, 266011, China
Local Institution - 007-035
Shanghai, 200032, China
Local Institution - 007-467
Bogotá, 0, Colombia
Local Institution - 007-465
Floridablanca, 0, Colombia
Local Institution - Unk021
Medellín, 5010, Colombia
Local Institution - Unk027
Montería, 230002, Colombia
Local Institution - 007-466
Valledupar, 200001, Colombia
Local Institution - 007-4000
Pula, 52100, Croatia
Specijalna Bolnica Medico
Rijeka, 51000, Croatia
Local Institution - 007-4002
Zagreb, 10000, Croatia
Multiscan - Ambulance klinicke onkologie se stacionarem - Horovice
Hořovice, 268 31, Czechia
Fakultni Nemocnice Olomouc
Olomouc, 779 00, Czechia
Nemocnice AGEL Ostrava-Vitkovice
Ostrava, 703 84, Czechia
Local Institution - 007-163
Prague, 128 08, Czechia
Fakultni nemocnice Bulovka
Praha 8 - Liben, 180 81, Czechia
Local Institution - 007-172
Odense, 5000, Denmark
Sjukhus Sonderjylland
Sønderborg, 6400, Denmark
Sygehus Lillebaelt - Vejle Sygehus
Vejle, 7100, Denmark
Docrates Cancer Center
Helsinki, 00180, Finland
Tampereen Yliopistollinen Sairaala (TAYS)
Tampere, 33520, Finland
Institut de Cancerologie de lOuest - Angers
Angers, 49055, France
Hopital Ambroise-Pare
Boulogne-Billancourt, 92100, France
Hopital Morvan
Brest, 29200, France
Centre Francois Baclesse
Caen, 14076, France
Centre Hospitalier Intercommunal de Creteil
Créteil, 94000, France
Hopital Michallon
La Tronche, 38700, France
Centre Hospitalier Universitaire Limoges
Limoges, 87042, France
Local Institution - 007-1993
Lorient, 56322, France
Local Institution - 007-199
Marseille, 13009, France
Hopital Nord de Marseille
Marseille, 13015, France
Hopital Arnaud de Villeneuve
Montpellier, 34090, France
Hopital Emile Muller
Mulhouse, 68100, France
Institut Curie
Paris, 75248, France
Local Institution - 007-1991
Rennes, 35033, France
Centre Hospitalier Universitaire De Nantes - Hopital Nord Laennec
Saint-Herblain, 44805, France
Institut de Cancerologie de lOuest - Saint-Herblain - Site Rene Gauducheau
Saint-Herblain, 44805, France
Les Hopitaux Universitaires de Strasbourg
Strasbourg, 67091, France
Hopital Bretonneau
Tours, 37044, France
Local Institution - 007-202
Villejuif, 94805, France
Local Institution - 007-790
Batumi, 6000, Georgia
Local Institution - 007-065
Tbilisi, 0112, Georgia
Local Institution - 007-795
Tbilisi, 0112, Georgia
Local Institution - 007-789
Tbilisi, 0144, Georgia
Local Institution - 007-063
Tbilisi, 0159, Georgia
Institute of Clinical Oncology - Tbilisi
Tbilisi, 0259, Georgia
Local Institution - 007-211A
Immenstadt im Allgäu, Bavaria, 87509, Germany
Local Institution - 007-675
Amberg, 92224, Germany
Local Institution - 007-2222
Augsburg, 86156, Germany
Local Institution - Link, M.
Bad Homburg, 61352, Germany
Local Institution - Eggers, H.
Braunschweig, 38114, Germany
Klinikum Chemnitz
Chemnitz, 09116, Germany
Kliniken der Stadt Koln
Cologne, 51109, Germany
Klinikum Esslingen
Esslingen am Neckar, 73730, Germany
Krankenhaus Nordwest
Frankfurt am Main, 60488, Germany
Universitatsklinikum Gieen und Marburg - Gieen
Giessen, 35392, Germany
LungenClinic Grosshansdorf
Grohansdorf, 22927, Germany
Asklepios Kliniken Barmbek
Hamburg, 22307, Germany
Local Institution - 007-2229
Hanover, 30625, Germany
Local Institution - 007-677
Heidelberg, 69126, Germany
Local Institution - 007-673
Heilbronn, 74072, Germany
Lungenklinik Hemer
Hemer, 58675, Germany
Local Institution - 007-225
Jena, 07747, Germany
Westpfalz-Klinikum - Kaiserslautern
Kaiserslautern, 67655, Germany
Klinikum Kassel
Kassel, 34125, Germany
Klinikverbund Allgau - Klinikum Kempten
Kempten, 87439, Germany
Local Institution - 007-2230
Krefeld, 47805, Germany
SLK-Kliniken - Fachklinik Lowenstein
Löwenstein, 74245, Germany
Universitatsklinikum Schleswig-Holstein - Campus Lubeck
Lübeck, 23538, Germany
Local Institution - 007-223
Mainz, 55131, Germany
Kliniken Maria Hilf
Mönchengladbach, 41063, Germany
Local Institution - 007-2228
München, 80336, Germany
Munchen Klinik Bogenhausen
München, 81925, Germany
Ruppiner Kliniken GmbH
Neuruppin, 16816, Germany
Sana Klinikum Offenbach
Offenbach, 63069, Germany
Pius-Hospital Oldenburg
Oldenburg, 26121, Germany
Local Institution - 007-2226
Treuenbrietzen, 14929, Germany
Local Institution - 007-2227
Trier, 54292, Germany
Bundeswehrkrankenhaus Ulm
Ulm, 89081, Germany
Henry Dunant Hospital Center
Athens, Attica, 11526, Greece
General Hospital for Thoracic Diseases Sotiria
Athens, 11527, Greece
"General Hospital of Athens "Alexandra""
Athens, 11528, Greece
"University General Hospital "Attikon" - General Hospital of West Attica "H Agia Varvara""
Athens, 124 62, Greece
University General Hospital of Heraklion (PAGNI)
Heraklion, 71110, Greece
University General Hospital of Larissa
Larissa, 41110, Greece
"General Oncology Hospital of Kifisias "Agioi Anargyroi""
Nea Kifissia, 145 64, Greece
Metropolitan Hospital
Piraeus, 185 47, Greece
Saint Lukes Hospital
Thessaloniki, 54645, Greece
Humanity & Health Clinical Trial Centre
Central, 0, Hong Kong
Pamela Youde Nethersole Eastern Hospital
Chai Wan, 0, Hong Kong
Queen Mary Hospital - Hong Kong
Hong Kong, 0, Hong Kong
Queen Elizabeth Hospital - Hong Kong
Kowloon, 0, Hong Kong
Semmelweis Egyetem - Pulmonologiai Klinika
Budapest, 1083, Hungary
Orszagos Koranyi Pulmonologiai Intezet
Budapest, 1121, Hungary
Orszagos Onkologiai Intezet
Budapest, 1122, Hungary
Farkasgyepui Tudogyogyintezet
Farkasgyepű, 8582, Hungary
Matrai Gyogyintezet
Gyöngyös, 3200, Hungary
Local Institution - 007-057
Tatabánya, 2800, Hungary
Reformatus Pulmonologiai Centrum
Törökbálint, 2045, Hungary
CIMS Hospital
Ahemdabad, 380060, India
Local Institution - 007-1574
Ahmedabad, 380015, India
Marathwada Cancer Hospital & Research Institute
Aurangabad, 431002, India
Local Institution - 007-1586
Bangalore, 560069, India
Local Institution - 007-1575
Belagavi, 590010, India
Local Institution - 007-1587
Howrah, 711103, India
Local Institution - 007-1564
Hyderabad, 500 082, India
Basavatarakam Indo American Cancer Hospital & Research Institute
Hyderabad, 500034, India
Local Institution - 007-1569
Jaipur, 302004, India
Local Institution - 007-1566
Kochi, 682041, India
Netaji Subhas Chandra Bose Cancer Hospital & Research Institute
Kolkata, 700094, India
Meenakshi Mission Hospital and Research Centre
Madurai, 625 107, India
Local Institution - Shetty, R.
Mangalore, 575002, India
Tata Memorial Centre - Tata Memorial Hospital
Mumbai, 400 012, India
Mysore Medical College and Research Institute
Mysore, 570001, India
Local Institution - 007-1588
New Delhi, 110029, India
Indraprastha Apollo Hospitals
New Delhi, 110076, India
Local Institution - 007-1578
New Delhi, 110085, India
Indira Gandhi Institute of Medical Sciences
Patna, 800014, India
Local Institution - 007-1571
Pune, 411004, India
Nirmal Hospital Pvt. Ltd.
Rajkot, 360005, India
Mahamana Pandit Madan Mohan Malviya Cancer Centre
Varanasi, 221010, India
Local Institution - 007-256
Cork, T12 E8YV, Ireland
Beaumont Hospital - Dublin
Dublin, 9, Ireland
St. Jamess Hospital
Dublin, D08 NHY1, Ireland
Tallaght University Hospital
Dublin, D24 NR0A, Ireland
University Hospital Galway
Galway, H91 YR71, Ireland
Local Institution - 007-258
Limerick, V94 F858, Ireland
University Hospital Waterford
Waterford, X91 ER8E, Ireland
Emek Medical Center
Afula, 1834111, Israel
Rambam Health Care Campus
Bat Galim, 3109601, Israel
Soroka Medical Center
Beersheba, 84101, Israel
Local Institution - 007-263
Holon, 5822012, Israel
Shaare Zedek Medical Center
Jerusalem, 9103102, Israel
Hadassah University Hospital Ein Kerem
Jerusalem, 9112001, Israel
Kaplan Medical Center
Rehovot, 7661041, Israel
Tel Aviv Sourasky Medical Center
Tel Aviv, 6423906, Israel
Ziv Medical Center
Zsfat, 1311001, Israel
Local Institution - Unk016
Aviano, 33081, Italy
Istituto Tumori Bari Giovanni Paolo II - IRCCS
Bari, 70124, Italy
Azienda Ospedaliero-Universitaria di Bologna - Policlinico Sant Orsola-Malpighi
Bologna, 40138, Italy
Azienda Socio Sanitaria Territoriale (ASST) degli Spedali Civili di Brescia
Brescia, 25123, Italy
Istituto di Candiolo - Fondazione del Piemonte per lOncologia
Candiolo, 10060, Italy
Azienda Ospedaliero - Universitaria Careggi
Florence, 50134, Italy
Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) - Ospedale Policlinico San Martino
Genova, 16132, Italy
"Istituto Romagnolo per lo Studio dei Tumori "Dino Amadori" - IRST"
Meldola, 47014, Italy
Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) - Ospedale San Raffaele
Milan, 20132, Italy
Istituto Europeo di Oncologia
Milan, 20141, Italy
Fondazione IRCCS - Istituto Nazionale dei Tumori
Milan, 20133, Italy
Local Institution - 007-318
Monza, 20900, Italy
Istituto Nazionale Tumori IRCCS Fondazione G. Pascale
Naples, 80131, Italy
Istituto Oncologico Veneto - IRCCS
Padua, 35128, Italy
Local Institution - Unk017
Padua, 35128, Italy
Azienda Ospedaliero-Universitaria di Parma
Parma, 43126, Italy
Azienda Ospedaliera di Perugia - Santa Maria della Misericordia
Perugia, 06132, Italy
Azienda Sanitaria Territoriale Pesaro Urbino
Pesaro, 61122, Italy
Ospedale Santa Maria delle Croci di Ravenna
Ravenna, 48121, Italy
Istituto Nazionale Tumori Regina Elena
Roma, 00144, Italy
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Roma, 00168, Italy
Local Institution - Unk030
Rozzano, 20089, Italy
Ospedale di Circolo e Fondazione Macchi
Varese, 21100, Italy
National Hospital Organization - Nagoya Medical Center
Nagoya, Aichi-ken, 460-0001, Japan
Jcho Chukyo Hospital
Nagoya, Chiba, 457-8510, Japan
Ehime University Hospital
Toon-shi, Ehime, 791-0295, Japan
Fukushima Medical University Hospital
Fukushima, Fukushima, 960-1295, Japan
Hyogo Cancer Center
Akashi, Hyōgo, 673-8558, Japan
Local Institution - 007-1593
Nishinomiya-Shi, Hyōgo, 663-8501, Japan
Kitasato University Hospital
Sagamihara, Kanagawa, 252-0375, Japan
Sendai Kousei Hospital
Sendai, Miyagi, 980-0873, Japan
Nagasaki University Hospital
Nagasaki, Nagasaki, 852-8501, Japan
Nara Medical University Hospital
Kashihara, Nara, 634-8522, Japan
National Hospital Organization Kinki-Chuo Chest Medical Center
Sakai-Shi, Osaka, 591-8555, Japan
National Hospital Organization Iwakuni Clinical Center
Iwakuni, 740-8510, Japan
Kanazawa University Hospital
Kanazawa, 920-8641, Japan
Kochi Medical School Hospital
Nankoku-shi, 783-8505, Japan
Osaka City General Hospital
Osaka, 534-0021, Japan
Osaka Prefectural Hospital Organization - Osaka International Cancer Institute
Osaka, 541-8567, Japan
Local Institution - 007-1164
Toyama, 930-0194, Japan
Local Institution - Unk079
Johor Bahru, Johor, 81100, Malaysia
Hospital Pulau Pinang
George Town, Pulau Pinang, 10990, Malaysia
Local Institution - Choo Khoon, O.
George Town, Pulau Pinang, 10990, Malaysia
Local Institution - Unk048
George Town, Pulau Pinang, 10990, Malaysia
Local Institution - Unk007
Petaling Jaya, Selangor, 46050, Malaysia
Sunway Medical Centre
Petaling Jaya, Selangor, 47500, Malaysia
Hospital Kuala Lumpur
Kuala Lumpur, 50586, Malaysia
Local Institution - Unk075
Kuala Lumpur, 50603, Malaysia
Cancer Treatment Clinic and Clinical Trials
Guadalajara, Jalisco, 44657, Mexico
Local Institution - Unk070
Guadalajara, Jalisco, 44670, Mexico
Local Institution - Unk034
Mexico City, Mexico City, 14080, Mexico
Local Institution - Unk049
Mexico City, Mexico City, 14080, Mexico
Arke SMO S.A. de C.V.
Mexico City, 6700, Mexico
Local Institution - Unk037
Monterrey, 64460, Mexico
Avix Investigacion Clinica
Monterrey, 64710, Mexico
Local Institution - Unk026
Monterrey, 64710, Mexico
Het Nederlands Kanker Instituut
Amsterdam, 1066 CX, Netherlands
Albert Schweitzer Ziekenhuis - Dordwijk
Dordrecht, 3318 AT, Netherlands
Local Institution - 007-303
Harderwijk, 3844, Netherlands
Radboud Universitair Medisch Centrum
Nijmegen, 6525 GA, Netherlands
Erasmus Medisch Centrum
Rotterdam, 3015 GD, Netherlands
Franciscus Gasthuis & Vlietland - Gasthuis
Rotterdam, 3045 PM, Netherlands
Local Institution - 007-308
The Hague, 2545 AA, Netherlands
Universitair Medisch Centrum Utrecht
Utrecht, 3584 CX, Netherlands
Local Institution - 007-305
Zwolle, 8025 AB, Netherlands
Health New Zealand - Te Whatu Ora - MidCentral
Palmerston North, 4414, New Zealand
Local Institution - 007-310
Drammen, 3004, Norway
Local Institution - Unk080
Trujillo, La Libertad, 13011, Peru
Local Institution - Unk022
Jesus Maria, Lima region, 15072, Peru
Local Institution - Unk031
Lima Cercado, Lima region, 15036, Peru
Local Institution - Unk024
Miraflores, Lima region, 15046, Peru
Local Institution - Unk042
San Isidro, Lima region, 0, Peru
Local Institution - Unk071
San Isidro, Lima region, 27, Peru
Local Institution - Unk054
Surquillo, Lima region, 15038, Peru
Local Institution - Unk051
Arequipa, 04001, Peru
Local Institution - Unk023
Arequipa, 09630, Peru
Local Institution - Unk044
Arequipa, 0, Peru
Local Institution - Unk040
Cusco, 0, Peru
Local Institution - Unk046
Lima, 15023, Peru
Local Institution - 007-1541
Bacolod City, 6100, Philippines
Local Institution - 007-1545
Cebu City, 6000, Philippines
Local Institution - 007-1544
Iloilo City, 5000, Philippines
Local Institution - 007-1543
Makati City, 1229, Philippines
Local Institution - 007-1542
Molo, 5000, Philippines
Local Institution - 007-1540
Quezon City, 1112, Philippines
Uniwersyteckie Centrum Kliniczne w Gdansku
Gdansk, 80-214, Poland
Swietokrzyskie Centrum Onkologii Samodzielny Publiczny Zaklad Opieki Zdrowotnej w Kielcach
Kielce, 25-734, Poland
Pratia MCM Krakow
Krakow, 30-727, Poland
MS Pneumed - Janusz Milanowski, Katarzyna Szmygin-Milanowska Spolka Jawna
Lublin, 20-064, Poland
Warminsko-mazurskie Centrum Chorob Pluc w Olsztynie
Olsztyn, 10-357, Poland
Mazowieckie Centrum Leczenia Chorob Pluc I Gruzlicy
Otwock, 05-400, Poland
Wielkopolskie Centrum Pulmonologii i Torakochirurgii im. Eugenii i Janusza Zeylandow
Poznan, 60-569, Poland
Pratia Poznan
Skorzewo, 60-185, Poland
Wojewodzki Szpital Zespolony im. L. Rydygiera w Toruniu
Torun, 87-100, Poland
Local Institution - 007-056
Warsaw, 01-138, Poland
Local Institution - 007-322
Warsaw, 02-781, Poland
Unidade Local de Saude de Coimbra
Coimbra, 3000-075, Portugal
Unidade Local de Saude do Alto Ave, E. P. E (Hospital da Senhora da Oliveira Guimaraes)
Guimarães, 4835-044, Portugal
Instituto Portugues De Oncologia De Lisboa Francisco Gentil
Lisbon, 1099-023, Portugal
Local Institution - 007-338-A
Lisbon, 1350-352, Portugal
Hospital CUF Descobertas
Lisbon, 1998-018, Portugal
Hospital CUF Porto
Porto, 14341, Portugal
Unidade Local de Saude de Santo Antonio, E. P. E - Hospital Geral de Santo Antonio
Porto, 4099-001, Portugal
Local Institution - 007-339
Porto, 4200-072, Portugal
Local Institution - 007-335
Vila Nova de Gaia, 4434-502, Portugal
Institutul Oncologic Bucuresti - Prof. Dr. Alexandru Trestioreanu
Bucharest, 022328, Romania
Medisprof
Cluj-Napoca, 400641, Romania
Centrul de Radioterapie Amethyst Cluj
Floreşti, 407280, Romania
Centrul de Oncologie Euroclinic
Iași, 700106, Romania
Oncocenter - Oncologie Clinica
Timișoara, 300166, Romania
Univerzitetski Klinicki Centar Srbije
Belgrade, 11129, Serbia
Institute for Pulmonary Diseases of Vojvodina
Kamenitz, 21204, Serbia
Local Institution - 007-694
Kragujevac, 34000, Serbia
Uzice General Hospital
Užice, 31000, Serbia
Raffles Hospital
Singapore, 188770, Singapore
Curie Oncology - Farrer - 10-05
Singapore, 217562, Singapore
Local Institution - 007-4010
Port Elizabeth, Eastern Cape, 6045, South Africa
Local Institution - 007-4013
Johannesburg, Gauteng, 2193, South Africa
Local Institution - 007-4012
Pretoria, Gauteng, 0084, South Africa
Inje University Haeundae Paik Hospital
Busan, 48108, South Korea
Pusan National University Hospital
Busan, 49241, South Korea
Chungbuk National University Hospital
Cheongju-si, 28644, South Korea
Kyungpook National University Chilgok Hospital
Daegu, 41404, South Korea
National Cancer Center - Korea
Goyang-si, 10408, South Korea
Inha University Hospital
Junggu, 400-712, South Korea
Seoul National University Hospital
Seoul, 03080, South Korea
Severance Hospital
Seoul, 03722, South Korea
Asan Medical Center
Seoul, 05505, South Korea
Samsung Medical Center
Seoul, 06351, South Korea
Korea University Guro Hospital
Seoul, 08308, South Korea
Catholic University of Korea St. Vincents Hospital
Suwon, 16247, South Korea
Local Institution - 007-611 A
Pamplona, Navarre, 31008, Spain
Complejo Hospitalario Universitario A Coruna
A Coruña, 15006, Spain
Institut Catala dOncologia Badalona
Badalona, 08916, Spain
Hospital de la Santa Creu i Sant Pau
Barcelona, 08025, Spain
Hospital Universitari Dexeus
Barcelona, 08028, Spain
Hospital Universitari Vall dHebron
Barcelona, 08035, Spain
Hospital Clinic de Barcelona
Barcelona, 08036, Spain
Local Institution - Unk081
Bilbao, 48013, Spain
Local Institution - Unk063
Burgos, 09006, Spain
Local Institution - Unk014
Jerez de la Frontera, 11407, Spain
Complejo Hospitalario Universitario Insular Materno Infantil
Las Palmas de Gran Canaria, 35016, Spain
Local Institution - Unk012
León, 24008, Spain
Institut Catala dOncologia - Hospital Duran i Reynals (ICO LHospitalet)
LHospitalet de Llobregat, 08908, Spain
Clinica Universidad de Navarra - Madrid
Madrid, 28027, Spain
Hospital Universitario Ramon y Cajal
Madrid, 28034, Spain
Hospital Clinico San Carlos
Madrid, 28040, Spain
Hospital Universitario Fundacion Jimenez Diaz
Madrid, 28040, Spain
Hospital Universitario 12 de Octubre
Madrid, 28041, Spain
Hospital Regional Universitario de Malaga - Hospital Civil
Málaga, 29009, Spain
Local Institution - 007-604
Santander, 39008, Spain
Hospital Clinico Universitario de Santiago
Santiago de Compostela, 15706, Spain
Hospital Universitario Virgen del Rocio
Seville, 41013, Spain
Hospital Clinico Universitario de Valencia
Valencia, 46010, Spain
Hospital Universitari i Politecnic La Fe
Valencia, 46026, Spain
Local Institution - Unk013
Gävle, 801 88, Sweden
Local Institution - 007-397
Sankt Gallen, 9007, Switzerland
Local Institution - 007-396
Villars-sur-Glâne, 1752, Switzerland
Local Institution - 007-127
Taichung, 402, Taiwan
China Medical University Hospital
Taichung, 404, Taiwan
Taichung Veterans General Hospital
Taichung, 40705, Taiwan
National Cheng Kung University Hospital
Tainan, 704, Taiwan
Chi Mei Hospital - Liouying
Tainan, 73657, Taiwan
National Taiwan University Hospital
Taipei, 10002, Taiwan
Taipei Veterans General Hospital
Taipei, 11217, Taiwan
Taipei Medical University - Shuang Ho Hospital, Ministry of Health and Welfare
Taipei, 23561, Taiwan
Chang Gung Memorial Hospital - Linkou Branch
Taoyuan District, 333, Taiwan
Local Institution - 007-139
Bangkok, 10210, Thailand
Navamindradhiraj University - Faculty of Medicine Vajira Hospital
Bangkok, 10300, Thailand
Baskent Universitesi Adana Uygulama Ve Arastirma Hastanesi
Alanya, 07400, Turkey (Türkiye)
T.C. Saglik Bakanligi - Istanbul Il Saglik Mudurlugu - Goztepe Prof. Dr. Suleyman Yalcin Sehir Hastanesi
Altındağ, 06100, Turkey (Türkiye)
Hacettepe Universitesi Kanser Enstitusu
Ankara, 06100, Turkey (Türkiye)
Memorial Ankara Hastanesi
Ankara, 6520, Turkey (Türkiye)
Liv Hospital Ankara
Ankara, 6680, Turkey (Türkiye)
Local Institution - 007-3810
Antalya, 07070, Turkey (Türkiye)
VM Medical Park Samsun Hastanesi
Atakum, 55200, Turkey (Türkiye)
Memorial Bahcelievler Hospital
Bahçelievler, 34180, Turkey (Türkiye)
Ege Universitesi Tip Fakultesi Hastanesi
Bornova, 35100, Turkey (Türkiye)
T.C. Saglik Bakanligi Ankara Bilkent Sehi�r Hastanesi�
Çankaya, 06800, Turkey (Türkiye)
Trakya Universitesi Tip Fakultesi
Edirne, 22130, Turkey (Türkiye)
Istanbul Universitesi Onkoloji Enstitusu
Fatih, 34093, Turkey (Türkiye)
Ozel Gaziantep Medical Point Hastanesi
Gaziantep, 27584, Turkey (Türkiye)
Local Institution - 007-069
Istanbul, 34214, Turkey (Türkiye)
Istanbul Onkoloji Hastanesi
Istanbul, 34846, Turkey (Türkiye)
Izmir Ekonomi Universitesi Medical Point Hastanesi
Izmir, 35575, Turkey (Türkiye)
Yeditepe Universitesi Kosuyolu Hastanesi
Kadıköy, 34718, Turkey (Türkiye)
Kocaeli Universitesi Arastirma ve Uygulama Hastanesi
Kocaeli, 41380, Turkey (Türkiye)
Inonu Universitesi Turgut Ozal Tip Merkezi
Malatya, 44000, Turkey (Türkiye)
Ankara Universitesi Tip Fakultesi - Cebeci Arastirma ve Uygulama Hastanesi
Mamak, 06620, Turkey (Türkiye)
Istanbul Universitesi Cerrahpasa Tip Fakultesi Hastanesi
Şişli, 34367, Turkey (Türkiye)
University Hospitals Birmingham NHS Foundation Trust
Birmingham, B9 5SS, United Kingdom
Local Institution - 007-415
Edinburgh, EH4 2XU, United Kingdom
Local Institution - 007-403
Kent, ME16 9QQ, United Kingdom
University Hospitals of Leicester NHS Trust
Leicester, LE1 5WW, United Kingdom
University College London Hospitals NHS Foundation Trust
London, NW1 2BU, United Kingdom
Guys and St Thomas NHS Foundation Trust
London, SE1 9RT, United Kingdom
The Christie NHS Foundation Trust
Manchester, M20 4BX, United Kingdom
Royal Surrey County Hospital NHS Foundation Trust
Surrey, GU2 7XX, United Kingdom
Related Links
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Study Officials
- STUDY DIRECTOR
Bristol-Myers Squibb
Bristol-Myers Squibb
Central Study Contacts
BMS Clinical Trials Contact Center www.BMSClinicalTrials.com
CONTACT
First line of the email MUST contain NCT # and Site #.
CONTACT
Study Design
- Study Type
- interventional
- Phase
- phase 2
- Allocation
- RANDOMIZED
- Masking
- NONE
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- INDUSTRY
- Responsible Party
- SPONSOR
- Expanded Access
- Yes
Study Record Dates
First Submitted
October 28, 2020
First Posted
November 3, 2020
Study Start
December 2, 2020
Primary Completion (Estimated)
October 31, 2028
Study Completion (Estimated)
October 31, 2029
Last Updated
March 18, 2026
Record last verified: 2026-03
Data Sharing
- IPD Sharing
- Will share
- Shared Documents
- STUDY PROTOCOL, SAP, CSR
- Time Frame
- See Plan Description
- Access Criteria
- See Plan Description
BMS will provide access to individual anonymized participant data upon request from qualified researchers, and subject to certain criteria. Additional information regarding Bristol Myer Squibb's data sharing policy and process can be found at https://www.bms.com/researchers-and-partners/clinical-trials-and-research.html