Success Metrics

Clinical Success Rate
66.5%

Based on 549 completed trials

Completion Rate
66%(549/826)
Active Trials
856(44%)
Results Posted
119%(656 trials)
Terminated
277(14%)

Phase Distribution

Ph phase_3
240
12%
Ph early_phase_1
34
2%
Ph phase_1
704
36%
Ph not_applicable
15
1%
Ph phase_2
905
47%
Ph phase_4
8
0%

Phase Distribution

738

Early Stage

905

Mid Stage

248

Late Stage

Phase Distribution1906 total trials
Early Phase 1First-in-human
34(1.8%)
Phase 1Safety & dosage
704(36.9%)
Phase 2Efficacy & side effects
905(47.5%)
Phase 3Large-scale testing
240(12.6%)
Phase 4Post-market surveillance
8(0.4%)
N/ANon-phased studies
15(0.8%)

Highest Phase Reached

Phase 4

Trial Status & Enrollment

Completion Rate

59.5%

549 of 923 finished

Non-Completion Rate

40.5%

374 ended early

Currently Active

856

trials recruiting

Total Trials

1,935

all time

Status Distribution
Active(908)
Completed(549)
Terminated(374)
Other(104)

Detailed Status

Completed549
Recruiting456
Active, not recruiting400
Terminated277
Withdrawn97
unknown97

Development Timeline

Analytics

Development Status

Total Trials
1935
Active
856
Success Rate
66.5%
Most Advanced
Phase 4

Trials by Phase

Early Phase 134 (1.8%)
Phase 1704 (36.9%)
Phase 2905 (47.5%)
Phase 3240 (12.6%)
Phase 48 (0.4%)
N/A15 (0.8%)

Trials by Status

recruiting45624%
withdrawn975%
active_not_recruiting40021%
completed54928%
not_yet_recruiting503%
suspended70%
terminated27714%
enrolling_by_invitation20%
unknown975%

Recent Activity

Clinical Trials (1,935)

Showing 20 of 1,935 trialsScroll for more
NCT04645602Early Phase 1

Merck IIT: RRP Pembro and Lenvatinib

Recruiting
NCT05317858Phase 3

Blood-brain Barrier (BBB) Opening Using Exablate Focused Ultrasound With Standard of Care Treatment of NSCLC Brain Mets

Recruiting
NCT03634241Phase 2

Pembrolizumab in Preventing Lung Cancer in Patients With Stage I-II Non-Small Cell Lung Cancer or High-Risk Pulmonary Nodules, the IMPRINT-Lung Study

Completed
NCT07223424Phase 2

Patient Preference for Subcutaneous vs. Intravenous Immune Therapy

Recruiting
NCT05925491Phase 2

Pembrolizumab in Locally Advanced Sinonasal Carcinoma

Recruiting
NCT06049212Phase 1

Sacituzumab Tirumotecan (MK-2870) as Monotherapy and in Combination With Pembrolizumab in Participants With Advanced Solid Tumors (MK-2870-008)

Active Not Recruiting
NCT05967182Phase 2

A Single-Arm Study of Pembrolizumab With Gemcitabine and Cisplatin as Perioperative Therapy for Potentially Resectable Intrahepatic Cholangiocarcinoma

Recruiting
NCT04671667Phase 2

Testing What Happens When an Immunotherapy Drug (Pembrolizumab) is Given by Itself Compared to the Usual Treatment of Chemotherapy With Radiation After Surgery for Recurrent Head and Neck Squamous Cell Carcinoma

Recruiting
NCT03435952Phase 1

Pembrolizumab With Intratumoral Injection of Clostridium Novyi-NT

Active Not Recruiting
NCT06576037Phase 1

Phase Ib Study of CBP-1019 in Combination With FOLFOX +/- Bevacizumab, Pembrolizumab, or Enzalutamide for Metastatic TRPV6-overexpressing Solid Tumors of Epithelial Origin

Recruiting
NCT07061977Phase 3

Induction Pembrolizumab and Chemotherapy Followed by Pembrolizumab Before Chemoradiation and Pembrolizumab Maintenance Compared to Standard Chemoradiation With Pembrolizumab Followed by Pembrolizumab Maintenance in High-Risk Cervical Cancer

Recruiting
NCT05064280Phase 2

Phase II Study of Pembrolizumab in Combination With Lenvatinib in Patients With TNBC, NSCLC, and Other Tumor Types and Brain Metastases

Recruiting
NCT03618550Phase 2

Phase II Study of Second- Line Pembrolizumab Plus GVD for Relapsed or Refractory Hodgkin Lymphoma

Recruiting
NCT06496568Phase 1

A Study Evaluating Single-agent Inavolisib, Inavolisib Plus Atezolizumab, and Inavolisib Plus Pembrolizumab in PIK3CA-Mutated Cancers

Recruiting
NCT06096844Phase 3

Chemotherapy Combined With Immunotherapy Versus Immunotherapy Alone for Older Adults With Stage IIIB-IV Lung Cancer, The ACHIEVE Trial

Recruiting
NCT06806852Phase 1

A Study to Test Whether Treatment With BI 770371 in Combination With Pembrolizumab With or Without Cetuximab Helps People With Head and Neck Cancer Compared With Pembrolizumab Alone

Recruiting
NCT05581004Phase 1

A Study to Evaluate the Safety, Pharmacokinetics, and Activity of Enzelkitug as a Single Agent and in Combination With Checkpoint Inhibitor in Participants With Locally Advanced or Metastatic Solid Tumors

Recruiting
NCT07213934Phase 1

Phase I/ II Trial Combining PD-1 Inhibition and Neoadjuvant Proton or Photon Radiation Therapy in Recurrent Head and Neck Squamous Cell Carcinoma

Recruiting
NCT04924062Phase 3

Pembrolizumab (MK-3475) Plus Gemcitabine/Cisplatin Versus Placebo Plus Gemcitabine/Cisplatin for First-Line Advanced and/or Unresectable Biliary Tract Carcinoma (BTC) (MK-3475-966/KEYNOTE-966)-China Extension Study

Completed
NCT06524544Phase 3

A Study Comparing the Combination of Pembrolizumab and Sacituzumab Govitecan Versus Standard of Care in the Treatment of Advanced Urothelial Cancer

Recruiting

Drug Details

Intervention Type
BIOLOGICAL
Total Trials
1,935