Success Metrics

Clinical Success Rate
66.4%

Based on 570 completed trials

Completion Rate
66%(570/858)
Active Trials
849(43%)
Results Posted
120%(682 trials)
Terminated
288(15%)

Phase Distribution

Ph phase_1
715
37%
Ph phase_4
8
0%
Ph not_applicable
15
1%
Ph phase_2
913
47%
Ph early_phase_1
34
2%
Ph phase_3
244
12%

Phase Distribution

749

Early Stage

913

Mid Stage

252

Late Stage

Phase Distribution1929 total trials
Early Phase 1First-in-human
34(1.8%)
Phase 1Safety & dosage
715(37.1%)
Phase 2Efficacy & side effects
913(47.3%)
Phase 3Large-scale testing
244(12.6%)
Phase 4Post-market surveillance
8(0.4%)
N/ANon-phased studies
15(0.8%)

Highest Phase Reached

Phase 4

Trial Status & Enrollment

Completion Rate

59.6%

570 of 957 finished

Non-Completion Rate

40.4%

387 ended early

Currently Active

849

trials recruiting

Total Trials

1,958

all time

Status Distribution
Active(903)
Completed(570)
Terminated(387)
Other(98)

Detailed Status

Completed570
Recruiting454
Active, not recruiting395
Terminated288
Withdrawn99
unknown92

Development Timeline

Analytics

Development Status

Total Trials
1958
Active
849
Success Rate
66.4%
Most Advanced
Phase 4

Trials by Phase

Early Phase 134 (1.8%)
Phase 1715 (37.1%)
Phase 2913 (47.3%)
Phase 3244 (12.6%)
Phase 48 (0.4%)
N/A15 (0.8%)

Trials by Status

active_not_recruiting39520%
unknown925%
terminated28815%
enrolling_by_invitation30%
recruiting45423%
suspended60%
withdrawn995%
not_yet_recruiting513%
completed57029%

Recent Activity

Clinical Trials (1,958)

Showing 20 of 1,958 trialsScroll for more
NCT06843447Phase 1

A Clinical Study of Raludotatug Deruxtecan in People With Ovarian Cancer (MK-5909-003)

Recruiting
NCT04960618Phase 2

Pembrolizumab in Combination With Gemcitabine in People With Advanced Mycosis Fungoides or Sézary Syndrome

Active Not Recruiting
NCT03244384Phase 3

Testing MK-3475 (Pembrolizumab) After Surgery for Localized Muscle-Invasive Bladder Cancer and Locally Advanced Urothelial Cancer

Active Not Recruiting
NCT06966700Phase 3

A Clinical Study of Sacituzumab Tirumotecan (Sac-TMT, MK-2870) in People With Breast Cancer (MK-2870-032)

Recruiting
NCT03486873Phase 3

Long-term Safety and Efficacy Extension Study for Participants With Advanced Tumors Who Are Currently on Treatment or in Follow-up in a Pembrolizumab (MK-3475) Study (MK-3475-587/KEYNOTE-587)

Recruiting
NCT06077760Phase 3

A Study of Intismeran Autogene (V940) Plus Pembrolizumab (MK-3475) Versus Placebo Plus Pembrolizumab in Participants With Non-small Cell Lung Cancer (V940-002)

Recruiting
NCT07252739Phase 2

KEYMAKER-U01 Substudy 01J: A Study of Pembrolizumab Plus MK-1084 in Participants With Non-Small Cell Lung Cancer (NSCLC) With Kirsten Rat Sarcoma Viral Oncogene Homolog (KRAS) G12C Mutations (MK-3475-01J/KEYMAKER-U01J)

Recruiting
NCT04729322Phase 2

Fecal Microbiota Transplant and Re-introduction of Anti-PD-1 Therapy (Pembrolizumab or Nivolumab) for the Treatment of Metastatic Colorectal Cancer in Anti-PD-1 Non-responders

Active Not Recruiting
NCT04267848Phase 3

Testing the Addition of a Type of Drug Called Immunotherapy to the Usual Chemotherapy Treatment for Non-small Cell Lung Cancer, an ALCHEMIST Treatment Trial (Chemo-IO [ACCIO])

Recruiting
NCT06780111Phase 1

Substudy 06E: Umbrella Study of Combination Therapies in Esophageal Cancer (MK-3475-06E/KEYMAKER-U06)

Recruiting
NCT06170788Phase 3

Sacituzumab Tirumotecan (MK-2870) in Combination With Pembrolizumab Versus Pembrolizumab Alone in Metastatic Non-small Cell Lung Cancer (NSCLC) With Programmed Cell Death Ligand 1 (PD-L1) Tumor Proportion Score (TPS) ≥ 50% (MK-2870-007)

Recruiting
NCT07094113Phase 1

AMG 410 Alone and in Combination With Other Agents in Participants With KRAS Altered Advanced or Metastatic Solid Tumors

Recruiting
NCT07198074Phase 3

Testing the Addition of an Antiangiogenic Drug (Bevacizumab) to Chemotherapy (Carboplatin and Paclitaxel) Combined With Immunotherapy (Pembrolizumab) for pMMR, TP53 Mutated Endometrial Cancer

Recruiting
NCT07486817Phase 2

Beamion 44: A Study to Test How Well Zongertinib is Tolerated by People With Advanced Non-small Cell Lung Cancer With HER2 Mutations When Given in Combination With Chemotherapy With or Without Pembrolizumab

Recruiting
NCT06188208Phase 1

A First-in-Human (FIH) Study to Evaluate the Safety and Tolerability of VVD-130850 in Participants With Advanced Solid and Hematologic Tumors

Terminated
NCT04214249Phase 2

BLAST MRD AML-1: BLockade of PD-1 Added to Standard Therapy to Target Measurable Residual Disease in Acute Myeloid Leukemia 1- A Randomized Phase 2 Study of Anti-PD-1 Pembrolizumab in Combination With Intensive Chemotherapy as Frontline Therapy in Patients With Acute Myeloid Leukemia

Active Not Recruiting
NCT07302347Phase 1

A Study of Pembrolizumab in Japanese Pediatric Participants With Solid Tumors or Lymphomas and Japanese Adult Participants With Merkel Cell Carcinoma (MK-3475-G21/KEYNOTE-G21)

Recruiting
NCT07639450Phase 1

N-3C01 Monotherapy and Combination With PD-(L)1 Inhibitors in Advanced Solid Tumors

Not Yet Recruiting
NCT07644039Phase 1

Study of PM54 in Combination With Immunotherapy in Adult Participants With Advanced Malignancies

Recruiting
NCT07578649Phase 3

Symbiotic-GYN-18: A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Chemotherapy in Adult Participants With Advanced or Recurrent MMR-proficient Endometrial Cancer

Not Yet Recruiting

Drug Details

Intervention Type
DRUG
Total Trials
1,958