Success Metrics

Clinical Success Rate
66.6%

Based on 585 completed trials

Completion Rate
67%(585/878)
Active Trials
839(42%)
Results Posted
120%(703 trials)
Terminated
293(15%)

Phase Distribution

Ph phase_2
922
47%
Ph phase_1
720
36%
Ph not_applicable
15
1%
Ph phase_3
253
13%
Ph phase_4
8
0%
Ph early_phase_1
33
2%

Phase Distribution

753

Early Stage

922

Mid Stage

261

Late Stage

Phase Distribution1951 total trials
Early Phase 1First-in-human
33(1.7%)
Phase 1Safety & dosage
720(36.9%)
Phase 2Efficacy & side effects
922(47.3%)
Phase 3Large-scale testing
253(13.0%)
Phase 4Post-market surveillance
8(0.4%)
N/ANon-phased studies
15(0.8%)

Highest Phase Reached

Phase 4

Trial Status & Enrollment

Completion Rate

59.8%

585 of 979 finished

Non-Completion Rate

40.2%

394 ended early

Currently Active

839

trials recruiting

Total Trials

1,981

all time

Status Distribution
Active(901)
Completed(585)
Terminated(394)
Other(101)

Detailed Status

Completed585
Recruiting441
Active, not recruiting398
Terminated293
Withdrawn101
unknown92

Development Timeline

Analytics

Development Status

Total Trials
1981
Active
839
Success Rate
66.6%
Most Advanced
Phase 4

Trials by Phase

Early Phase 133 (1.7%)
Phase 1720 (36.9%)
Phase 2922 (47.3%)
Phase 3253 (13.0%)
Phase 48 (0.4%)
N/A15 (0.8%)

Trials by Status

recruiting44122%
not_yet_recruiting583%
completed58530%
suspended90%
active_not_recruiting39820%
enrolling_by_invitation40%
withdrawn1015%
terminated29315%
unknown925%

Recent Activity

Clinical Trials (1,981)

Showing 20 of 1,981 trialsScroll for more
NCT05422794Phase 1

Testing the Addition of Anti-Cancer Drug, ZEN003694 (ZEN-3694) and PD-1 Inhibitor (Pembrolizumab), to Standard Chemotherapy (Nab-Paclitaxel) Treatment in Patients With Advanced Triple-Negative Breast Cancer

Recruiting
NCT04887805Phase 2

Lenvatinib and Pembrolizumab Maintenance Therapy for the Treatment of Patients of Advanced Unresectable Pancreatic Cancer

Active Not Recruiting
NCT06524544Phase 3

A Study Comparing the Combination of Pembrolizumab and Sacituzumab Govitecan-hziy Versus Standard of Care in the Treatment of Advanced Urothelial Cancer

Recruiting
NCT06131398Phase 1

A Study of AMG 355 Alone and in Combination With Pembrolizumab in Participants With Advanced Solid Tumors

Completed
NCT06989112Phase 3

DESTINY-Endometrial01: A Phase III Study of Trastuzumab Deruxtecan Plus Rilvegostomig or Pembrolizumab as First-Line Treatment of HER2-Expressing (IHC 3+/2+), Mismatch Repair Proficient (pMMR) Endometrial Cancer

Recruiting
NCT07756645Phase 3

A Study to Assess Intravenous ABBV-1480 Combined With Chemotherapy Versus Pembrolizumab Combined With Chemotherapy for the First Line Treatment of Locally Advanced/Metastatic Non-Small Cell Lung Cancer in Adult Participants

Not Yet Recruiting
NCT04164082Phase 2

Testing the Addition of an Anti-cancer Drug, Pembrolizumab, to the Usual Intravesical Chemotherapy Treatment (Gemcitabine) for the Treatment of BCG-Unresponsive Non-muscle Invasive Bladder Cancer

Active Not Recruiting
NCT06770582Phase 2

Testing the Addition of the Immunotherapy Drug, Pembrolizumab, to Radiation Therapy Compared to the Usual Chemotherapy Treatment During Radiation Therapy for Bladder Cancer, PARRC Trial

Recruiting
NCT04267848Phase 3

Testing the Addition of a Type of Drug Called Immunotherapy to the Usual Chemotherapy Treatment for Non-small Cell Lung Cancer, an ALCHEMIST Treatment Trial (Chemo-IO [ACCIO])

Recruiting
NCT04675710Phase 2

Pembrolizumab, Dabrafenib, and Trametinib Before Surgery for the Treatment of BRAF-Mutated Anaplastic Thyroid Cancer

Active Not Recruiting
NCT06391775Phase 1

Trial to Assess the Safety and Preliminary Efficacy of GEN1055 on Malignant Solid Tumors as Monotherapy and as Combination Therapy

Terminated
NCT07420439Phase 2

Treatment in Patients With Advanced Non-Small Cell Lung Carcinoma and Interstitial Lung Disease

Not Yet Recruiting
NCT07166601Phase 1

M0324 as Monotherapy and in Combination With Pembrolizumab or Chemotherapy in Participants With Selected Advanced Solid Tumors

Recruiting
NCT05805501Phase 2

A Study of Immune Checkpoint Inhibitor Combinations With Axitinib in Participants With Untreated Locally Advanced Unresectable or Metastatic Renal Cell Carcinoma

Active Not Recruiting
NCT06731478Phase 3

Study of TDXd, Chemotherapy, Pembrolizumab, and Trastuzumab in First-Line Metastatic HER2-Positive Gastric or Gastroesophageal Junction Cancer

Recruiting
NCT07744126Phase 2

A Study to Assess Adverse Events, Change in Disease Activity and Optimal Dose of Intravenous (IV) Telisotuzumab Adizutecan With IV Pembrolizumab for First-Line Treatment of Adult Participants With Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma

Not Yet Recruiting
NCT07541170Phase 3

A Study to Evaluate the Efficacy and Safety of Divarasib Compared With Investigator's Choice of Immunotherapy or Observation in Participants With Resected Stage II-III KRAS G12C-Positive Non-Small Cell Lung Cancer (NSCLC)

Recruiting
NCT07198074Phase 3

Testing the Addition of an Antiangiogenic Drug (Bevacizumab) to Chemotherapy (Carboplatin and Paclitaxel) Combined With Immunotherapy (Pembrolizumab) for pMMR, TP53 Mutated Endometrial Cancer

Recruiting
NCT07343596Not Applicable

Study to Identify Biomarkers of Oral Cavity Cancer Response to Neoadjuvant Immunotherapy Prior to Definitive Surgery

Recruiting
NCT07063745Phase 2

A Study to Compare the Combination of Navlimetostat (BMS-986504) With Pembrolizumab and Chemotherapy Versus Placebo Plus Pembrolizumab and Chemotherapy in First-line Metastatic Non-small Cell Lung Cancer Participants With Homozygous MTAP Deletion

Recruiting

Drug Details

Intervention Type
BIOLOGICAL
Total Trials
1,981