Relationship Between MUC1 Expression and Gustatory Function in Postmenopausal Females

NCT04606524 | Unknown DMC

• 1 other identifier: 8-2020
• Study Type: observational
• Target: 50
• Locations: 0 countries
• Sites: N/A

Brief Summary

50 females will be included in this study. they will be divided into 2 groups (study group which will include 25 postmenopausal females - and control group which will include premenopausal females) For testing gustatory function, a whole mouth above threshold taste test will be carried out in which a concentration of sucrose, sodium chloride, citric acid and quinine hydrochloride solutions were used for sweet, salty, sour and bitter types of taste respectively . Saliva will be collected to evaluate MUC1 expression

Conditions

Taste, Altered

Outcome Measures

Primary Outcomes (1)

• Alterations of the gustatory function in postmenopausal females

  , a whole mouth above threshold taste test will be carried out in which a concentration of sucrose, sodium chloride, citric acid and quinine hydrochloride solutions were used for sweet, salty, sour and bitter types of taste respectively

  12-18 month

Secondary Outcomes (1)

• MUC1 expression

  12-18 month

Study Arms (2)

study group

25 postmenopausal females will be included in this study

control group

25 premenopausal females will be included in this tudy

Eligibility Criteria

• Age: 20 Years - 65 Years
• Sex: female
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

study will include 50 healthy females free from any systemic diseases or inder any medications that may affect gustatory function divided into 2 groups study group and it will include 25 postmenopausal females control group it will include 25 postmenopausal females

You may not qualify if:

• those who have any systemic diseases (such as diabetes, nutritional deficiency, cardiovascular, respiratory and endocrinal disorders).
• Also any history that could affect gustatory function (e.g medications \&radiotherapy or smoking

Sponsors & Collaborators

• October 6 University: lead

Biospecimen

Retention: SAMPLES WITH DNA

Analysis of epithelial oral mucosal MUC1 expression level in saliva

MeSH Terms

Conditions

Dysgeusia

Condition Hierarchy (Ancestors)

Taste Disorders; Sensation Disorders; Neurologic Manifestations; Nervous System Diseases; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Officials

• reham aggour

  October 6 University

  STUDY DIRECTOR

Central Study Contacts

amira abdelwhab

CONTACT

01007647877; amira.abdelwhab.dent@o6u.edu.eg

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Dr.

Study Record Dates

• First Submitted: August 29, 2020
• First Posted: October 28, 2020
• Study Start: October 1, 2020
• Primary Completion: October 1, 2021
• Study Completion: December 1, 2021
• Last Updated: October 28, 2020

Record last verified: 2020-10