NCT03548038|Completed
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Sponsor study identifier
observational
21
1 country
2
Study Start
May 24, 2018
Actual (reported)Primary Completion
December 20, 2019
Actual (reported)Study Completion
May 4, 2020
Actual (reported)It is commonly believed that a link exists between BMI and taste perception. One group of researchers observed that women who are obese experience reduced taste sensitivity when compared to normal-weight controls. Others have compared taste sensitivity between lean and obese subjects and found no significant differences. The inconsistencies in these studies demonstrate how much variation in taste sensitivity is possible when different factors are applied in research. Throughout several studies, one element remains constant - bariatric surgery causes appetite aversions. These changes in appetite and food preference likely have a large influence on the overall magnitude of post-surgical weight loss. Although many studies have investigated the changes in taste preference after bariatric surgery, few, if any, have focused on changes in sweet taste perception.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
May 4, 2020
Actual (reported)Click on a node to explore related trials.
Some registry-reported names shown below are not yet linked in this graph.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
May 24, 2018
Actual (reported)May 24, 2018
Actual (reported)June 6, 2018
Actual (reported)December 20, 2019
Actual (reported)May 4, 2020
Actual (reported)Taste Perception on an Interval Scale
Taste perception will be assessed by the subjects' responses to varying sucrose solutions. The interval scale begins with "barely detectable" at zero and goes up to "strongest imaginable" at 10. Subjects will be asked to draw an "X" at the location on the graph corresponding to their perception.
Change from baseline to one month after bariatric surgery
All subjects will be patients scheduled for bariatric surgery. There is only one arm in this study.
All subjects will complete a procedure to determine their taste sensitivity to sweet tastants.
Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.
Women aged 21-70 will be recruited from the University of Missouri Bariatric Surgery Clinic.
Elizabeth Parks
Columbia, Missouri, 65212, United States
University of Missouri
Columbia, Missouri, 65212, United States
Bueter M, Miras AD, Chichger H, Fenske W, Ghatei MA, Bloom SR, Unwin RJ, Lutz TA, Spector AC, le Roux CW. Alterations of sucrose preference after Roux-en-Y gastric bypass. Physiol Behav. 2011 Oct 24;104(5):709-21. doi: 10.1016/j.physbeh.2011.07.025. Epub 2011 Jul 30.
Scruggs DM, Buffington C, Cowan GS Jr. Taste Acuity of the Morbidly Obese before and after Gastric Bypass Surgery. Obes Surg. 1994 Feb;4(1):24-28. doi: 10.1381/096089294765558854.
Before bariatric surgery, the subject will lightly scrape the inside of their cheek to harvest cells. These cell will be frozen for future DNA extraction and detection of taste receptor genes, T1R2 and T1R3.
Elizabeth J Parks, PhD
University of Missouri-Columbia
21 participants (actual enrollment reported by the registry).
First Submitted
May 24, 2018
First Posted
June 6, 2018
Study Start
May 24, 2018
Actual (reported)Relationship Between MUC1 Expression and Gustatory Function in Postmenopausal Females
Contact the study team to confirm eligibility.
Pepino MY, Finkbeiner S, Beauchamp GK, Mennella JA. Obese women have lower monosodium glutamate taste sensitivity and prefer higher concentrations than do normal-weight women. Obesity (Silver Spring). 2010 May;18(5):959-65. doi: 10.1038/oby.2009.493. Epub 2010 Jan 14.
Primary Completion
December 20, 2019
Actual (reported)Study Completion
May 4, 2020
Actual (reported)Last Updated
November 2, 2020
Record last verified: 2020-03
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Source: ClinicalTrials.gov.
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