Correlation of Clinical Types and Complexity of Coronary Artery Disease With Patients' Metabolic Profile
CorLipid
1 other identifier
observational
1,050
1 country
1
Brief Summary
The purpose of the research project is to investigate the potential association of the complexity and the severity of coronary artery disease (as assessed via SYNTAX score) with patients' metabolic profile. The aim of the study is to combine biochemical, clinical and laboratory data in order to create an algorithm that will enable an individualized therapeutic patient approach.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Jul 2019
Typical duration for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
July 12, 2019
CompletedFirst Submitted
Initial submission to the registry
October 2, 2020
CompletedFirst Posted
Study publicly available on registry
October 8, 2020
CompletedPrimary Completion
Last participant's last visit for primary outcome
June 1, 2021
CompletedStudy Completion
Last participant's last visit for all outcomes
August 1, 2021
CompletedOctober 12, 2020
October 1, 2020
1.9 years
October 2, 2020
October 9, 2020
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Relationship between metabolic profile and the SYNTAX score
Serum metabolomic biomarkers (ceramides, acyl-carnitines, total fatty acids and protein markers: Galectin-3, Neutrophil Gelatinase-Associated Lipocalin, Adiponectin, ApolipoproteinB/ ApolipoproteinΑ-Ι) will be quantified using metabolomics-based methods and enzyme-linked immunosorbent assay. The SYNTAX score will be calculated for all patients. Correlation between patients' metabolic profile and the SYNTAX score will be performed.
12 months
Secondary Outcomes (5)
Concentration of serum ceramide species
12 months
Concentration of serum acyl-carnitines
12 months
Concentration of serum total fatty acids
12 months
Concentration of serum selective protein markers
12 months
Major Adverse Cardiovascular and Cerebrovascular Events
12 months
Study Arms (4)
SYNTAX score = 0
Patients with nonobstructive CAD (≤50 % diameter stenosis)
0 < SYNTAX score <=22
Low SYNTAX group
23<=SYNTAX score<=32
Intermediate SYNTAX group
SYNTAX score>=33
High SYNTAX group
Interventions
Targeted and untargeted metabolomics-based analysis will be performed using Gas Chromatography tandem Mass Spectometry and Liquid Chromatography tandem Mass Spectrometry, in order to quantify serum biomarkers.
Eligibility Criteria
Adults, of both genders, who are admitted in the Department of Cardiology in the AHEPA University General Hospital of Thessaloniki and undergo coronary angiography for clinical purposes will be studied. Patients with a previous history of coronary artery disease will be excluded. The study includes subjects who 1) have suspected CAD and undergo a scheduled diagnostic angiogram for clinical reasons, and 2) are hospitalized because of an acute coronary syndrome and thus undergo diagnostic angiography (without previous history of CAD).
You may qualify if:
- Patients giving voluntary written consent to participate in the study
- Adults
- Patients without previous history of coronary artery disease
- Patients who are admitted in the Department of Cardiology in the AHEPA University General Hospital of Thessaloniki and undergo coronary angiography for clinical purposes
You may not qualify if:
- Cardiac Arrest at admission
- Patients with serious concurrent disease and life expectancy of \< 1 year
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- AHEPA University Hospitallead
- ANALYSIS MEDICAL SAcollaborator
- Aristotle University Of Thessalonikicollaborator
Study Sites (1)
AHEPA University Hospital
Thessaloniki, 54636, Greece
Related Publications (4)
Sianos G, Morel MA, Kappetein AP, Morice MC, Colombo A, Dawkins K, van den Brand M, Van Dyck N, Russell ME, Mohr FW, Serruys PW. The SYNTAX Score: an angiographic tool grading the complexity of coronary artery disease. EuroIntervention. 2005 Aug;1(2):219-27. No abstract available.
PMID: 19758907BACKGROUNDKaragiannidis E, Moysidis DV, Papazoglou AS, Panteris E, Deda O, Stalikas N, Sofidis G, Kartas A, Bekiaridou A, Giannakoulas G, Gika H, Theodoridis G, Sianos G. Prognostic significance of metabolomic biomarkers in patients with diabetes mellitus and coronary artery disease. Cardiovasc Diabetol. 2022 May 7;21(1):70. doi: 10.1186/s12933-022-01494-9.
PMID: 35525960DERIVEDDeda O, Panteris E, Meikopoulos T, Begou O, Mouskeftara T, Karagiannidis E, Papazoglou AS, Sianos G, Theodoridis G, Gika H. Correlation of Serum Acylcarnitines with Clinical Presentation and Severity of Coronary Artery Disease. Biomolecules. 2022 Feb 23;12(3):354. doi: 10.3390/biom12030354.
PMID: 35327546DERIVEDKaragiannidis E, Sofidis G, Papazoglou AS, Deda O, Panteris E, Moysidis DV, Stalikas N, Kartas A, Papadopoulos A, Stefanopoulos L, Karvounis H, Gika H, Theodoridis G, Sianos G. Correlation of the severity of coronary artery disease with patients' metabolic profile- rationale, design and baseline patient characteristics of the CorLipid trial. BMC Cardiovasc Disord. 2021 Feb 8;21(1):79. doi: 10.1186/s12872-021-01865-2.
PMID: 33557756DERIVED
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Target Duration
- 1 Year
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Georgios Sianos, Associate Professor of Cardiology MD, PhD, FESC, AHEPA University Hospital
Study Record Dates
First Submitted
October 2, 2020
First Posted
October 8, 2020
Study Start
July 12, 2019
Primary Completion
June 1, 2021
Study Completion
August 1, 2021
Last Updated
October 12, 2020
Record last verified: 2020-10