Aortic Stiffness and Distensibility as Predictor to Severity of Coronary Artery Disease

NCT03615963 | Completed

• 1 other identifier: Aortic stiffness
• Study Type: observational
• Target: 150
• Locations: 1 country
• Sites: 1

Brief Summary

Assess the relationship of Aortic root distensibility and stiffness with the extent of coronary artery disease as assessed by SYNTAX score compared to a matched cohort of patients with normal coronary angiography

Conditions

Coronary Artery Disease

Outcome Measures

Primary Outcomes (1)

• compare aortic stiffness and elasticity in normal subjects and patient with coronary artery disease

  aortic stiffness by echocardiography ⊿P=Ps-Pd mmHg. ⊿D=As-Ad cm. local arterial stiffness can be calculated using the following formula: Aortic distensibility (AD) cm2/dyn= (2x⊿D)/((Adx⊿p)) Aortic stiffness index(SI)= ln (Ps/Pd)/(⊿D/Ad) no units ln is the natural logarithm Arterial strain = (⊿D)/Ad no units The elastic modulus E(p) = (⊿P)/Strain ( mmHg/cm) tissue doppler imaging (TDI) The TDI of expansion peak velocity during systole (SAo) and early (EAo) and late (AAo) diastolic peak velocities (m/s)are obtained then coronary angiography will be done to differentiate the 2 groups into normal and others have coronary artery disease using Syntax score( SS) Patients were divided into three tertiles: SS LOW ≤22 22\< SSMID ≤32 SS HIGH \>32

  1 hour

Study Arms (2)

normal

patient complains of anginal chest pain but coronary angiography is normal

Diagnostic Test: echocardiography and coronary angiography

coronary artery disease

patient complains of chest pain with coronary angiography showing atherosclerotic plaques causing luminal obstruction

Diagnostic Test: echocardiography and coronary angiography

Interventions

echocardiography and coronary angiography DIAGNOSTIC_TEST

transthoracic echocardiography will be done for all subjects to measure aortic stiffness and elaticity then coronary angiography was used to differentiate between normal subjects and who have coronary artery disease

coronary artery disease; normal

Eligibility Criteria

• Age: Up to 70 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

patient suspected to have coronary artery disease based on clinical date will underwent echocardiography to measure aortic root stiffness and elasticity then coronary angiography will be done to differentiate normal and coronary artery disease . then aortic root stiffness and elasticity will be compared between the two groups. is aortic root stiffness and elasticity can predict coronary artery disease and its severity

You may qualify if:

• all patients suspected to have coronary artery disease

You may not qualify if:

• Hypertension( SBP\>140mmhg or DBP\>90mmhg)
• Previous coronary stenting
• Previous CABG
• Renal diseases.
• Decompensated liver disease.
• Connective tissue diseases.
• Aortic valve disease ( more than mild aortic stenosis or regurgitation)

Sponsors & Collaborators

• Assiut University: lead

Study Sites (1)

Helen Sami Anwar

Asyut, Egypt

Location

Related Publications (3)

• Wilkinson IB, Cockcroft JR, McEniery CM. Aortic stiffness as a cardiovascular risk predictor. BMJ. 2015 Jul 14;351:h3764. doi: 10.1136/bmj.h3764. No abstract available.

  PMID: 26173600 BACKGROUND

• Wang F, Ye P, Luo L, Xiao W, Qi L, Bian S, Wu H, Sheng L, Xiao T, Xu R. Association of serum lipids with arterial stiffness in a population-based study in Beijing. Eur J Clin Invest. 2011 Sep;41(9):929-36. doi: 10.1111/j.1365-2362.2011.02481.x. Epub 2011 Feb 14.

  PMID: 21314825 BACKGROUND

• Zhang YJ, Iqbal J, Campos CM, Klaveren DV, Bourantas CV, Dawkins KD, Banning AP, Escaned J, de Vries T, Morel MA, Farooq V, Onuma Y, Garcia-Garcia HM, Stone GW, Steyerberg EW, Mohr FW, Serruys PW. Prognostic value of site SYNTAX score and rationale for combining anatomic and clinical factors in decision making: insights from the SYNTAX trial. J Am Coll Cardiol. 2014 Aug 5;64(5):423-32. doi: 10.1016/j.jacc.2014.05.022.

  PMID: 25082573 BACKGROUND

MeSH Terms

Conditions

Coronary Artery Disease

Interventions

Echocardiography; Coronary Angiography

Condition Hierarchy (Ancestors)

Coronary Disease; Myocardial Ischemia; Heart Diseases; Cardiovascular Diseases; Arteriosclerosis; Arterial Occlusive Diseases; Vascular Diseases

Intervention Hierarchy (Ancestors)

Cardiac Imaging Techniques; Diagnostic Imaging; Diagnostic Techniques and Procedures; Diagnosis; Ultrasonography; Heart Function Tests; Diagnostic Techniques, Cardiovascular; Angiography; Radiography

Study Officials

• Salwa Demitry

  Assiut University

  STUDY DIRECTOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal investigator

Study Record Dates

• First Submitted: July 5, 2018
• First Posted: August 6, 2018
• Study Start: October 1, 2017
• Primary Completion: March 31, 2018
• Study Completion: June 1, 2018
• Last Updated: August 28, 2018

Record last verified: 2018-08

Locations

EG (1)