Association of Coronary Artery Disease With Lewis and ABO Blood Group Phenotypes
1 other identifier
observational
210
1 country
1
Brief Summary
Primary objective- To study the association of Lewis antigen and A, B, O blood group phenotypes with coronary artery disease patients attending the tertiary care hospital in Kerala. The secondary objective-To find the association of Lewis antigen and A, B, O blood group phenotypes with smoking, alcohol use, diabetes, hypertension and dyslipidemia. A case-control study to compare the prevalence of Lewis(a-b-) blood group among confirmed cardiac cases with the prevalence of the same among the general population and thereby find out if individuals with Lewis(a-b-) are more at risk of developing coronary artery disease. This may provide an economical and simple method for identifying subjects at increased risk for coronary artery disease and subsequently lead to more focused preventive measures and eventually to a specific treatment.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Nov 2019
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
November 1, 2019
CompletedPrimary Completion
Last participant's last visit for primary outcome
April 30, 2021
CompletedStudy Completion
Last participant's last visit for all outcomes
April 30, 2021
CompletedFirst Submitted
Initial submission to the registry
April 29, 2022
CompletedFirst Posted
Study publicly available on registry
May 11, 2022
CompletedMay 16, 2022
May 1, 2022
1.5 years
April 29, 2022
May 10, 2022
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Prevalence of Lewis and ABO blood group phenotypes in cases and controls.
Prevalence Lewis and ABO phenotype in cases will be compared to prevalence of the same in controls.
Lewis and ABO phenotype of the study participants was determined immediately after sample collection
Study Arms (2)
CASE(coronary artery disease)
Patients with confirmed coronary artery disease
CONTROL
People without coronary artery disease
Eligibility Criteria
70 cases attending the Cardiology department who satisfy the inclusion and exclusion criteria were taken as cases. 140 (age and gender-matched) healthy blood donors who were eligible to donate blood as per the inclusion and exclusion criteria of Drugs and Cosmetics Rules, 1945 were taken as controls.
You may qualify if:
- \- Patients in the age group of 30-55 years at the time of data collection diagnosed with coronary artery disease based on positive changes in coronary angiogram (more than 70% coronary stenosis)
You may not qualify if:
- Patients with other systemic illnesses like malignancy, autoimmune diseases.
- Patients who were not willing to participate in the study.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Jubilee Mission Medical College & Research Institute
Thrissur, Kerala, 680005, India
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Design
- Study Type
- observational
- Observational Model
- CASE CONTROL
- Time Perspective
- RETROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Principal Investigator
Study Record Dates
First Submitted
April 29, 2022
First Posted
May 11, 2022
Study Start
November 1, 2019
Primary Completion
April 30, 2021
Study Completion
April 30, 2021
Last Updated
May 16, 2022
Record last verified: 2022-05