The Short and Long-term Cardiovascular Consequences of Critical Illness: The C3 Study
C3
3 other identifiers
observational
80,000
1 country
3
Brief Summary
The aim this study will be to find out which patients are at risk of heart attacks/strokes up to several years after discharge from an ICU. This study will also investigate whether treatments and events occurring in ICU contribute to this risk.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Aug 2020
Typical duration for all trials
3 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
August 10, 2020
CompletedFirst Submitted
Initial submission to the registry
September 3, 2020
CompletedFirst Posted
Study publicly available on registry
September 11, 2020
CompletedPrimary Completion
Last participant's last visit for primary outcome
August 1, 2023
CompletedStudy Completion
Last participant's last visit for all outcomes
December 31, 2023
CompletedApril 20, 2023
April 1, 2023
3 years
September 3, 2020
April 19, 2023
Conditions
Outcome Measures
Primary Outcomes (3)
Mortality
5 years
Major adverse cardiovascular and vascular events
5 years
Arrhythmia
5 years
Secondary Outcomes (1)
Hospital re-admission
5 years
Study Arms (1)
ICU
Patients treated on a general adult intensive care unit
Interventions
Eligibility Criteria
Adult patients admitted to a general adult intensive care unit at one or more of the study sites between 2006 and 1st of August 2023.
You may qualify if:
- Aged 16 years or above.
- Admitted to an intensive care unit at a study site from 2006 onwards
You may not qualify if:
- Patients that have informed their participating site that they do not wish their electronic records would be used for future research
- Patients who inform us directly that they don't wish their records used in this research study
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (3)
Royal Berkshire NHS Foundation Trust
Reading, Berkshire, RG1 5AN, United Kingdom
Oxford University Hospitals
Oxford, Oxfordshire, OX3 9DU, United Kingdom
Imperial College Healthcare NHS Trust
London, W12 0HS, United Kingdom
Related Links
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- STUDY DIRECTOR
Peter Watkinson
University of Oxford
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- RETROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
September 3, 2020
First Posted
September 11, 2020
Study Start
August 10, 2020
Primary Completion
August 1, 2023
Study Completion
December 31, 2023
Last Updated
April 20, 2023
Record last verified: 2023-04
Data Sharing
- IPD Sharing
- Will not share
Individual participant data will not be made publically available due to privacy and legal implications. Secondary analysis of the study will be considered on a case by case basis.