Critical Illness Related Cardiac Arrest (CIRCA)

NCT04219384 | Unknown

• 1 other identifier: ICNARC/02/11/2019
• Study Type: observational
• Target: 1,800
• Locations: 1 country
• Sites: 1

Brief Summary

CIRCA aims to determine the incidence and outcomes of in-hospital cardiac arrest (IHCA) in UK intensive care units (ICUs) and explore associated risk factors with ICU and hospital survival and quality of survival following hospital discharge.

Conditions

Critical Illness

Keywords

Critical Illness Related Cardiac Arrest

Outcome Measures

Primary Outcomes (1)

• Incidence

  Incidence of critical illness related cardiac arrest

  Up to 12 months

Secondary Outcomes (12)

• Subsequent incidence of in-hospital cardiac arrest

  Up to 12 months

• Survival status at hospital discharge

  Up to 12 months

• Survival status at 12 months

  12 months

• Patient quality of life measured through EQ-5D-5L questionnaire completion at 3 months

  3 months

• Patient quality of life measured through EQ-5D-5L questionnaire completion at 6 months

  6 months

Study Arms (1)

Critical-illness related cardiac arrest (CIRCA)

Those experiencing a critical illness-related cardiac arrest in a participating adult, general ICU

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Adults having cardiac arrest (defined as receipt of chest compressions and/or defibrillation) after admission to an Intensive Care Unit (ICU) participating in the Case Mix Programme in a hospital participating in the National Cardiac Arrest Audit

You may qualify if:

• Age 18 years old or more; and either
• Cardiac arrest (defined as receipt of chest compressions or defibrillation) occurring while in-hospital and within intensive care (defined as either ICU, HDU or combined ICU/HDU); or
• Family member of a patient surviving to discharge from intensive care after a cardiac arrest within ICU

Sponsors & Collaborators

• Intensive Care National Audit & Research Centre: lead
• North Bristol NHS Trust: collaborator

Study Sites (1)

Intensive Care National Audit & Research Centre

London, WC1V 6AZ, United Kingdom

RECRUITING

Related Publications (2)

• Darnell R, Broomhall J, Newell C, Gendall E, Harrison D, Rowan K, Doidge J, Mouncey P, Gould D, Thomas M. Critical Illness Related Cardiac Arrest (CIRCA): a prospective investigation of the incidence and outcome of cardiac arrest within intensive care units in the United Kingdom. Resuscitation. 2025 Dec 22:110933. doi: 10.1016/j.resuscitation.2025.110933. Online ahead of print.

  PMID: 41443583 DERIVED

• Darnell R, Newell C, Edwards J, Gendall E, Harrison D, Sprinckmoller S, Mouncey P, Gould D, Thomas M. Critical illness-related cardiac arrest: Protocol for an investigation of the incidence and outcome of cardiac arrest within intensive care units in the United Kingdom. J Intensive Care Soc. 2022 Nov;23(4):493-497. doi: 10.1177/17511437211055899. Epub 2022 Mar 13.

  PMID: 36751345 DERIVED

MeSH Terms

Conditions

Critical Illness

Condition Hierarchy (Ancestors)

Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Matt Thomas, MD

  North Bristol NHS Trust

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Doug Gould

CONTACT

02072699277; doug.gould@icnarc.org

Robert Darnell

CONTACT

02072699277; robert.darnell@icnarc.org

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: November 21, 2019
• First Posted: January 7, 2020
• Study Start: January 27, 2020
• Primary Completion: June 1, 2021
• Study Completion: July 1, 2022
• Last Updated: October 5, 2020

Record last verified: 2020-10

Data Sharing

• IPD Sharing: Will share

Locations

GB (1)