Outcomes of Patients Who Survived Treatment on an Intensive Care Unit for COVID-19 in England and Wales
OPTIC-19
3 other identifiers
observational
319,600
1 country
1
Brief Summary
This retrospective cohort study aims to characterise outcomes for patients treated on an intensive care unit (ICU) with COVID-19 in England and Wales, one year after discharge from hospital. Outcomes will be compared with patients admitted as an emergency to an ICU for other conditions. The study will use existing national audit data linked to routine healthcare datasets.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Aug 2020
Longer than P75 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
August 1, 2020
CompletedFirst Submitted
Initial submission to the registry
April 7, 2021
CompletedFirst Posted
Study publicly available on registry
April 8, 2021
CompletedPrimary Completion
Last participant's last visit for primary outcome
February 28, 2025
CompletedStudy Completion
Last participant's last visit for all outcomes
February 28, 2025
CompletedAugust 14, 2024
July 1, 2024
4.6 years
April 7, 2021
August 13, 2024
Conditions
Outcome Measures
Primary Outcomes (1)
Mortality Rate
Mortality after discharge from hospital
One year
Secondary Outcomes (5)
Rate of emergency hospital admission
one year
Rate of emergency hospital admission for respiratory infection
one year
Rate of emergency hospital admission for a major adverse cardiac event
one year
Rate of emergency hospital admission for a venous thrombotic event
one year
Rate of development of end stage renal failure
one year
Study Arms (2)
Covid19
Patients admitted to an adult (16 years or over), general ICU in England or Wales as an emergency with confirmed COVID-19 between 1st January to 1st July 2020.
Non Covid19
Patients admitted to an adult (16 years or over), general ICU in England or Wales as an emergency without confirmed COVID-19 between 1st July 2016 and 1st July 2020.
Interventions
Eligibility Criteria
Patients admitted to an adult (16 years or over), general ICU in England or Wales as an emergency between 1st July 2016 and 1st July 2020 who survived to hospital discharge.
You may qualify if:
- Age 16 years or over
- Admitted to an adult, general ICU in England or Wales as an emergency (unplanned)
- Admitted to ICU for either: a) confirmed COVID-19 between 1st January to 1st July 2020 or b) without confirmed COVID-19 between 1st July 2016 and 1st July 2020-
You may not qualify if:
- Patients who died in hospital after treatment on an ICU
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Critical Care Research Group, Nuffield Department of Clinical Neurosciences, University of Oxford
Oxford, Oxfordshire, OX3 9DU, United Kingdom
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Peter Watkinson, MD
University of Oxford
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- RETROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
April 7, 2021
First Posted
April 8, 2021
Study Start
August 1, 2020
Primary Completion
February 28, 2025
Study Completion
February 28, 2025
Last Updated
August 14, 2024
Record last verified: 2024-07
Data Sharing
- IPD Sharing
- Will not share
Individual participant data will not be made publicly available due to privacy and legal implications.