Investigating the Neural Systems That Support the Reappraisal Tactics Leading to Positive Emotion

NCT04532242 | Unknown

• 1 other identifier: 1606445-A
• Study Type: interventional
• Target: 40
• Locations: 1 country
• Sites: 1

Brief Summary

Community participants will visit the neuroimaging facilities at CU Boulder for a single experimental session. In all studies, participants will complete pre-task questionnaires (trait measures), and a brief mood measure, followed by a task training in which a research assistant describes and gives examples of cognitive reappraisal in response to negative images. Then, participants complete an event-related, picture-based cognitive reappraisal task for 30-45 minutes, during which whole-brain BOLD signal will be collected. Following the task, participants will once again respond to a mood measure, and answer a series of questions regarding the task they have completed, including difficulty of regulation, or any images that were personally relevant. The researchers predict that the positive emotion induction will result in powerful effects on self-reported emotion which may or may not interact with the cognitive reappraisal condition. Participants will be trained to use reappraisal to increase positive emotion, and they will be asked to respond with the reappraisal tactic category that best fits the reappraisal they used for each image. The researchers predict greater use of future-focused tactics will be associated with greater reappraisal success, which in turn will result in greater recruitment of vmPFC and connectivity between vmPFC and other prefrontal regions.

Conditions

Behavior

Keywords

cognitive reappraisal; cognition

Outcome Measures

Primary Outcomes (2)

• Self-reported emotion ratings

  Participants will be rating their negative and positive emotions during the intervention. They will be asked "How positive do you feel?" and "How negative do you feel?" after each image and will answer on a scale of 1-9 with 1 being low ("I don't feel positive at all" or "I don't feel negative at all") to 9 ("I feel very positive" or "I feel very negative").

  During the task intervention which will last 50 minutes

• Whole brain BOLD signal

  Changes in blood oxygen dependent level (EPI sequences) from the whole brain collected in a 3T MRI scanner with a head-coil specifically for fMRI.

  Immediately after the intervention

Secondary Outcomes (4)

• Mood ratings

  Pre-intervention and immediately after the intervention

• Task difficulty

  Immediately after the intervention

• Task compliance

  Immediately after intervention

• Experience with task images

  Immediately after intervention

Other Outcomes (2)

• Depression trait differences

  Baseline

• Emotional regulation trait differences

  Baseline

Study Arms (1)

fMRI Participants

EXPERIMENTAL

Participants will be scanned in an fMRI session lasting approximately 45-50 minutes and will be shown negative images for which they will have to take on a cognitive reappraisal tactic. All participants will be taken through the scanner with the same reappraisal protocol for each participant.

Behavioral: Cognitive reappraisal

Interventions

Cognitive reappraisal BEHAVIORAL

Participants will be trained to follow instructions to look/respond naturally or use cognitive reappraisal to reframe or reconsider a negative picture to decrease negative emotion.

fMRI Participants

Eligibility Criteria

• Age: 18 Years - 55 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Community members ages 18-55
• Fluent in English
• Without present psychotic symptoms

You may not qualify if:

• None

Sponsors & Collaborators

• University of Denver: lead
• Wake Forest University: collaborator

Study Sites (1)

University of Denver

Denver, Colorado, 80208, United States

RECRUITING

MeSH Terms

Conditions

Behavior

Study Officials

• Kateri McRae, Ph.D.

  University of Denver

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Kateri McRae, Ph.D.

CONTACT

303-871-3632; Kateri.McRae@du.edu

Alyssa Asmar, B.A

CONTACT

alyssa.asmar@du.edu

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: August 25, 2020
• First Posted: August 31, 2020
• Study Start: June 22, 2023
• Primary Completion: August 31, 2023
• Study Completion: November 1, 2023
• Last Updated: July 25, 2023

Record last verified: 2023-07

Locations

US (1)