Effects of Smoking State on Decision Making

NCT04826276 | Completed Results

• 2 other identifiers: IRB000799497R21DA045970-03
• Study Type: interventional
• Target: 5
• Locations: 1 country
• Sites: 1

Brief Summary

Adult smokers will be tested using behavioral and neuroimaging measures after smoking as usual and after overnight abstinence.

Conditions

Behavior

Keywords

Decision making

Outcome Measures

Primary Outcomes (2)

• Effort Based Decision Making

  number of high effort selections

  approximately 2 weeks

• Distress Tolerance Behavior

  duration on measures of distress tolerance

  approximately 2 weeks

Study Arms (1)

All Subjects

EXPERIMENTAL

for the abstinence intervention, 12+ hours after smoking will be assessed before assessments following smoking as normal For the satiated intervention, smoking as normal will be assessed first before assessments following 12+ hours of abstinence from smoking

Other: smoking abstinence; Other: smoking satiety

Interventions

smoking abstinence OTHER

participants will be asked to not smoke for at least 12 hours

All Subjects

smoking satiety OTHER

participants will be asked to smoke as usual

All Subjects

Eligibility Criteria

• Age: 18 Years - 55 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Aged 18-55 years
• Smokes cigarettes or e-cigarettes
• Negative urine drug screen

You may not qualify if:

• Unstable or serious medical or mental health condition
• History of serious head trauma
• Pregnancy
• Unsuitable for MRI
• Weight \> 350 pounds (maximum allowed for MRI)

Sponsors & Collaborators

• National Institute on Drug Abuse (NIDA): collaborator
• Wake Forest University Health Sciences: lead

Study Sites (1)

Wake Forest University School of Medicine

Winston-Salem, North Carolina, 27101, United States

Location

MeSH Terms

Conditions

Behavior

Results Point of Contact

• Title: Dr. Merideth Addicott
• Organization: Wake Forest University School of Medicine

merideth.addicott@wfusm.edu

336-716-7792

Study Officials

• Merideth Addicott, PhD

  Wake Forest University Health Sciences

  PRINCIPAL INVESTIGATOR

Publication Agreements

• PI is Sponsor Employee: No
• Restrictive Agreement: No

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Model Details: Participants will be instructed to smoke as usual before one fMRI study visit (satiated state) and to abstain from using all tobacco/nicotine for 12 hours before the other fMRI study visit (abstinence and/or withdrawn state). The order of the satiated and abstinence/withdrawn study visits will be randomized and counterbalanced across participants.

Study Record Dates

• First Submitted: March 26, 2021
• First Posted: April 1, 2021
• Study Start: September 1, 2022
• Primary Completion: March 28, 2023
• Study Completion: March 28, 2023
• Last Updated: May 1, 2026
• Results First Posted: May 1, 2026

Record last verified: 2022-09

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)