The Effect Of Blood Flow Restrıcted Resistive And Aerobic Exercises in Chronic Obstructive Pulmonary Patients

NCT04521959 | Completed

• 1 other identifier: istanbul medipol university
• Study Type: interventional
• Target: 40
• Locations: 1 country
• Sites: 1

Brief Summary

Patients with chronic obstructive pulmonary disease (COPD) classified by a pulmonologist in accordance with the GOLD criteria will be randomly divided into 2 groups. The first group (n = 20) was accompanied by blood flow restriction (CAC), 3 times a week, 8 weeks, 1RMx 30% intensity, 10 repetitions, 3 sets, 30 seconds rest interval, progressive resistance exercise (PRE) and after 5 minutes of rest by cycling. Progressive aerobic exercise (AE) (BFR PRE + AE group) in the target heart rate range of 50-80% intensity will be applied to the second group (n = 20), PRE and AE (PRE + AE group) performed at the same intensity and duration without BFR.

Conditions

Copd

Keywords

COPD, blood flow restriction, exercise

Outcome Measures

Primary Outcomes (12)

• FEV1/FVC rate

  respiratory function test

  eight weeks

• creatine kinase

  muscle breakdown marker

  eight weeks

• c reactive protein

  thrombus formation risk marker

  eight weeks

• d-dimer

  venous thromboembolism marker

  eight weeks

• total antioxidant status

  oxidative stress marker

  eight weeks

• total oxidant status

  oxidative stress marker

  eight weeks

• interleukin 6

  inflammation marker

  eight weeks

• oxygen saturation

  blood gas test

  three times a week

• heart rate

  for exercise dose determination

  three times a week

• six minute walk test

  strength evaluation

  eight weeks

• ST george's respiratory questionnaire

  used to evaluate the effects of respiratory disease's symptoms and illness

  eight weeks

• quadriceps muscle diameter

  Measurement of change in muscle volume

  eight weeks

Study Arms (2)

Blood Flow Restricted Aerobic and Resistance Exercise Group

ACTIVE COMPARATOR

kan akımı kısıtlanarak.direnç ve bisikletle aerobik egzersiz uygulanacak

Procedure: Blood flow restricted and normal aerobic exercise and resistance exercise

Normal aerobik ve direnç egzersiz grubu

ACTIVE COMPARATOR

Normal şartlarda aerobik ve direnç egzersizi uygulanacak

Procedure: Blood flow restricted and normal aerobic exercise and resistance exercise

Interventions

Blood flow restricted and normal aerobic exercise and resistance exercise PROCEDURE

Interventions of the same duration and intensity will be applied to two groups.

Blood Flow Restricted Aerobic and Resistance Exercise Group; Normal aerobik ve direnç egzersiz grubu

Eligibility Criteria

• Age: 40 Years - 78 Years
• Gender Eligibility Details: Since COPD affects male gender more, the number of male patients participating in the intervention is higher than female patients.
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Being diagnosed with mild to severe COPD according to GOLD criteria in the age range of 40-78
• No drug change for at least 30 days
• Not participating in a structured activity program for at least six months
• Have the ability to cooperate.

You may not qualify if:

• Presence of any pathology that limits physical activity performance
• Presence of severe or unstable heart disease
• Presence of peripheral artery disease
• Being in an exacerbation period of the disease
• Presence of another active disease (rheumatic, oncological, traumatic etc.)
• Any neurological or orthopedic disease that prevents exercise

Sponsors & Collaborators

• Medipol University: lead

Study Sites (1)

Karabük Üniversitesi Araştırma Hastanesi Göğüs Hastalıkları Kliniği

Karabük, Karabük Province, 78600, Turkey (Türkiye)

Location

Related Publications (8)

• Patterson SD, Hughes L, Warmington S, Burr J, Scott BR, Owens J, Abe T, Nielsen JL, Libardi CA, Laurentino G, Neto GR, Brandner C, Martin-Hernandez J, Loenneke J. Blood Flow Restriction Exercise: Considerations of Methodology, Application, and Safety. Front Physiol. 2019 May 15;10:533. doi: 10.3389/fphys.2019.00533. eCollection 2019.

  PMID: 31156448 BACKGROUND

• Nolan CM, Rochester CL. Exercise Training Modalities for People with Chronic Obstructive Pulmonary Disease. COPD. 2019 Dec;16(5-6):378-389. doi: 10.1080/15412555.2019.1637834. Epub 2019 Nov 4.

  PMID: 31684769 BACKGROUND

• Scott BR, Loenneke JP, Slattery KM, Dascombe BJ. Exercise with blood flow restriction: an updated evidence-based approach for enhanced muscular development. Sports Med. 2015 Mar;45(3):313-25. doi: 10.1007/s40279-014-0288-1.

  PMID: 25430600 BACKGROUND

• Kacin A, Strazar K. Frequent low-load ischemic resistance exercise to failure enhances muscle oxygen delivery and endurance capacity. Scand J Med Sci Sports. 2011 Dec;21(6):e231-41. doi: 10.1111/j.1600-0838.2010.01260.x. Epub 2011 Mar 8.

  PMID: 21385216 BACKGROUND

• Loenneke JP, Allen KM, Mouser JG, Thiebaud RS, Kim D, Abe T, Bemben MG. Blood flow restriction in the upper and lower limbs is predicted by limb circumference and systolic blood pressure. Eur J Appl Physiol. 2015 Feb;115(2):397-405. doi: 10.1007/s00421-014-3030-7. Epub 2014 Oct 22.

  PMID: 25338316 BACKGROUND

• Wilson JM, Lowery RP, Joy JM, Loenneke JP, Naimo MA. Practical blood flow restriction training increases acute determinants of hypertrophy without increasing indices of muscle damage. J Strength Cond Res. 2013 Nov;27(11):3068-75. doi: 10.1519/JSC.0b013e31828a1ffa.

  PMID: 23446173 BACKGROUND

• Berzosa C, Cebrian I, Fuentes-Broto L, Gomez-Trullen E, Piedrafita E, Martinez-Ballarin E, Lopez-Pingarron L, Reiter RJ, Garcia JJ. Acute exercise increases plasma total antioxidant status and antioxidant enzyme activities in untrained men. J Biomed Biotechnol. 2011;2011:540458. doi: 10.1155/2011/540458. Epub 2011 Mar 9.

  PMID: 21436993 BACKGROUND

• Wilk M, Krzysztofik M, Gepfert M, Poprzecki S, Golas A, Maszczyk A. Technical and Training Related Aspects of Resistance Training Using Blood Flow Restriction in Competitive Sport - A Review. J Hum Kinet. 2018 Dec 31;65:249-260. doi: 10.2478/hukin-2018-0101. eCollection 2018 Dec.

  PMID: 30687436 BACKGROUND

MeSH Terms

Conditions

Pulmonary Disease, Chronic Obstructive; Motor Activity

Condition Hierarchy (Ancestors)

Lung Diseases, Obstructive; Lung Diseases; Respiratory Tract Diseases; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Behavior

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: TRIPLE
• Who Masked: PARTICIPANT, CARE PROVIDER, OUTCOMES ASSESSOR
• Masking Details: 40 COPD patients will be randomised divided into two equal groups according to age, gender and disease severity.
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: PhD Student

Model Details: Two randomized controlled intervention groups will be formed.

Study Record Dates

• First Submitted: August 18, 2020
• First Posted: August 21, 2020
• Study Start: August 19, 2020
• Primary Completion: February 23, 2021
• Study Completion: May 25, 2021
• Last Updated: April 16, 2025

Record last verified: 2025-04

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)