Exercise Training and Inflammatory Mediators in COPD
Effect of Exercise Training on Inflammatory Mediators in COPD
1 other identifier
interventional
28
1 country
1
Brief Summary
Chronic obstructive pulmonary disease (COPD) is widely spread all over the world. It is predicted to be the third leading cause of death by 2020\[1\]. COPD is a common, preventable treatable disease that is characterized by an airflow limitation which is not fully reversable\[2\].
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for not_applicable
Started Jan 2019
Shorter than P25 for not_applicable
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
January 1, 2019
CompletedFirst Submitted
Initial submission to the registry
February 21, 2019
CompletedFirst Posted
Study publicly available on registry
February 25, 2019
CompletedPrimary Completion
Last participant's last visit for primary outcome
April 17, 2019
CompletedStudy Completion
Last participant's last visit for all outcomes
April 27, 2019
CompletedDecember 20, 2019
December 1, 2019
4 months
February 21, 2019
December 18, 2019
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Enzyme linked immunosorbent assay for serum cytokines levels change
The interleukines were determined by ELISA assays with commercial kits
Baseline, 6 months
Study Arms (2)
ET
ACTIVE COMPARATORActive Comparator: ET Endurance training were prformed. Intensity was gradually increased.
RT
OTHERResistance training were prformed. Intensity was gradually increased.
Interventions
Eligibility Criteria
You may qualify if:
- COPD diagnosed by pulmonary function testing
- Clinically stable
- Abscence of other obstructive diseases
- Signed written consent
You may not qualify if:
- Neuromuscular diseases -Severe psychiatric, neurologic or musculoskeletal conditions and /or instable--- --
- cardiovascular diseases.
- Contre-indications to physical therapy
- Acute exacerbations a month before the intervention
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Amal Acheche
Sousse, 4002, Tunisia
Related Publications (4)
authors non mentionned., global initiative for chronic lung disease. 2017
BACKGROUNDMolfino NA, Jeffery PK. Chronic obstructive pulmonary disease: histopathology, inflammation and potential therapies. Pulm Pharmacol Ther. 2007;20(5):462-72. doi: 10.1016/j.pupt.2006.04.003. Epub 2006 May 6.
PMID: 16798034BACKGROUNDBarnes PJ. Inflammatory mechanisms in patients with chronic obstructive pulmonary disease. J Allergy Clin Immunol. 2016 Jul;138(1):16-27. doi: 10.1016/j.jaci.2016.05.011. Epub 2016 May 27.
PMID: 27373322BACKGROUNDBarnes PJ. Cellular and molecular mechanisms of chronic obstructive pulmonary disease. Clin Chest Med. 2014 Mar;35(1):71-86. doi: 10.1016/j.ccm.2013.10.004. Epub 2013 Dec 12.
PMID: 24507838BACKGROUND
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Amal Acheche, Phd
Faculty of Medicine of Sousse Sousse, Tunisia
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- DOUBLE
- Who Masked
- CARE PROVIDER, INVESTIGATOR
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- PhD student
Study Record Dates
First Submitted
February 21, 2019
First Posted
February 25, 2019
Study Start
January 1, 2019
Primary Completion
April 17, 2019
Study Completion
April 27, 2019
Last Updated
December 20, 2019
Record last verified: 2019-12
Data Sharing
- IPD Sharing
- Will not share