High Fat vs High Protein and Appetite Hormones

NCT04518930 | Completed

• 1 other identifier: HF vs HP-8/2020
• Study Type: interventional
• Target: 52
• Locations: 1 country
• Sites: 1

Brief Summary

This study will investigate the effects of high-protein, high-fat snacks, specifically Greek yogurt, and peanuts, on satiety, gut hormones, and insulin secretion in overweight and obese women. The hypothesis posited that peanuts will exhibit a more beneficial impact on satiety, gut hormones, and insulin levels compared to Greek yogurt. The two-arm parallel randomized trial will involve 52 participants aged 30 to 40 with a BMI between 25-35 kg/m²,and they will be randomly divided into peanut (n=26) and Greek yogurt (n=26) groups. Pre-snack, BMI and dietary intake will be assessed. Appetite sensations will be gauged using a visual analog scale (VAS) upon arrival, and at 30- and 60-minutes post-snack. Pre- and post-snacking, plasma levels of cholecystokinin (CCK), Peptide Tyrosine-Tyrosine (PYY), Glucagon Like Peptide-1 (GLP-1), Ghrelin (GHRL), and insulin will be analyzed.

Conditions

Body Weight; Appetitive Behavior; Dietary Exposure; Hormone Deficiency

Keywords

High fat; High protein; Satiety hormones; Appetite; Obesity

Outcome Measures

Primary Outcomes (2)

• Appetite hormones

  The effects of peanut snacking versus plain Greek yogurt on appetite hormones will be measured on Cholecystokinin, Ghrelin, Peptide YY, and Glucagon Like Peptide-1 and Insulin levels

  one week

• Appetite sensations

  The effect of peanut snacking versus plain Greek yogurt on appetite sensations will be measured using validated visual analog scale (VAS) questionnaire

  8 weeks

Study Arms (2)

high fat

EXPERIMENTAL

26 participants will be provided with (35) g of roasted, not salted peanuts as snack.

Other: Peanuts or plain Greek yogurt

high protein

EXPERIMENTAL

26 participants will be provided with (380) g of Plain Greek yogurt after as snack.

Other: Peanuts or plain Greek yogurt

Interventions

Peanuts or plain Greek yogurt OTHER

Two different types of dietary snacks

Also known as: snack

high fat; high protein

Eligibility Criteria

• Age: 30 Years - 40 Years
• Gender Eligibility Details: Overweight and obese females
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Women aged between 30 and 40 years, with a body mass index (BMI) ranging from 25 to 35 kg/m², engaged in light exercise 1-3 times per week (activity factor 1.375) and adhered to a routine of consuming three regular meals, along with two daily snacks, and maintaining a water intake of eight cups and do not have any allergies, particularly to peanuts, and yogurt.

You may not qualify if:

• Women aged below 30 years or above 40 years, BMI below 25 kg/m² or above 35 kg/m², engaged in little or no exercise or engaged in moderate to heavy exercise, pregnant or lactating mothers, had allergies to nuts, peanuts, yogurt, milk, or milk products, using medications, hormonal therapy, supplements, oral contraceptives, or herbal/botanical products claimed to suppress appetite. Women in menopausal state, in their menstrual cycle days, or within one week before their menstrual cycle days will be excluded. Those with chronic diseases such as cardiovascular diseases, diabetes, hypertension, kidney diseases, thyroid disorders, gastrointestinal diseases, polycystic ovary syndrome, or androgen disorders, following a weight-reducing diet, experiencing sleep disorders, or sleeping less than 8 hours per day, and consuming less than 8 cups of water per day will also excluded.

Sponsors & Collaborators

• Al-Balqa Applied University: lead
• University of Jordan: collaborator

Study Sites (1)

Nahla S Al-Bayyari

Salt, Balqa Governorate, 19117, Jordan

Location

Related Publications (1)

• Al-Bayyari N, Alhameedy M, Omoush R, Ghazzawi H. Exploring the effects of high protein versus high fat snacks on satiety, gut hormones and insulin secretion in women with overweight and obesity: A randomized clinical trial. Obes Pillars. 2025 Sep 27;16:100212. doi: 10.1016/j.obpill.2025.100212. eCollection 2025 Dec.

  PMID: 41079153 DERIVED

MeSH Terms

Conditions

Body Weight; Appetitive Behavior; Obesity

Interventions

Snacks

Condition Hierarchy (Ancestors)

Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Behavior, Animal; Behavior; Overweight; Overnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases

Intervention Hierarchy (Ancestors)

Meals; Food; Diet, Food, and Nutrition; Physiological Phenomena; Food and Beverages

Study Officials

• Nahla S Al-Bayyari, Ph.D

  Al-Balqa Applied University

  STUDY DIRECTOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Clinical professor

Study Record Dates

• First Submitted: August 15, 2020
• First Posted: August 19, 2020
• Study Start: December 1, 2021
• Primary Completion: April 1, 2022
• Study Completion: October 22, 2023
• Last Updated: October 8, 2024

Record last verified: 2024-10

Data Sharing

• IPD Sharing: Will not share

Locations

JO (1)